Q46E58 (APGM_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	Mbar_A0860

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: InterPro phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402_A		PRO_1000068380

Sequences

	Sequence		Length	Mass (Da)
	Q46E58 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 11A2604B38A2AF2A	FASTA	398	42,895
	10 20 30 40 50 60 MKYAVLIGDG MADYPIDKLG GKTILQAAQT PAMDYIAAHG KIGLAKTIPD GLPAGSDVAN 70 80 90 100 110 120 MSILGYDPAV YYSGRAPLEA ASMGVALASD DVAFRCNLVT IEHGRIKDYS AGHISSEEAR 130 140 150 160 170 180 ILIETLDAEL GNEELSFYPG ISYRHLLIAK DNLGAETECT PPHDITGKKI EEYLPGGKEG 190 200 210 220 230 240 DFFSDLIKKS MIVLELHPVN LRRIEEGKNP ANSIWVWGQG SAPKFTPFRE LYEKTGAVIS 250 260 270 280 290 300 AVDLLKGIGV YAGMDVIEVQ GATGYLDTNY EGKASAAIEV LKTRDLVFVH VEAPDEAGHE 310 320 330 340 350 360 GSIDKKLKAV EDFDSRIVAP ILKHAKTSDE PFTILVLPDH PTPISIKTHA RDPVPFAVYR 370 380 390 TDKTDSDSAE AFDEESAKKG SLGLVKASDL IGILVKAK

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69834.1.
RefSeq	YP_304414.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46E58.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46E58.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3627272.
GenomeReviews	Gene locus Mbar_A0860 in contig CP000099_GR.
KEGG	mba:Mbar_A0860.
NMPDR	fig|269797.3.peg.334.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04733.
HOGENOM	HBG463247.
OMA	REGRCGM.
ProtClustDB	PRK04200.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A0860-MONOMER.
Family and domain databases
HAMAP	MF_01402_A. ApgM_A. [Tree]
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kinase_put. IPR006124. Metalloenzyme. [Graphical view]
Gene3D	G3DSA:3.40.720.10. Alk_phosphtse. 2 hits.
KO	K15635.
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. ApgM. 1 hit. TIGR02535. Hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METBF

Accession

Primary (citable) accession number: Q46E58

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	September 13, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program