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Q46E43 (PSD_METBF) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain
  2. Phosphatidylserine decarboxylase beta chain
Gene names
Name:psd
Ordered Locus Names:Mbar_A0875
OrganismMethanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]
Taxonomic identifier269797 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00664

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphatidylethanolamine biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functioncofactor binding

Inferred from electronic annotation. Source: InterPro

phosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Phosphatidylserine decarboxylase beta chain By similarity
PRO_0000262285
Chain171 – 20333Phosphatidylserine decarboxylase alpha chain By similarity
PRO_0000262286

Sites

Site170 – 1712Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue1711Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q46E43 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: C8246C8E24C46189

FASTA20323,036
        10         20         30         40         50         60 
MLAKGSEPWL FTATFITALF AVLSRAMNSS HLNHVAYIAM AMTFFMVLFF RDPERKVEVS 

        70         80         90        100        110        120 
DTYMISPADG TVIDIRGRKI CIFMFLQNVH VNRAPISGKI REITYKKGGY LPAFCKDSER 

       130        140        150        160        170        180 
NERNEFIIHS KYGDVSVMQI AGTIARRIVS YSRVNDNIEQ GQRIGMIRLG SRVDVTIPHD 

       190        200 
FEIIVRKGER VLAGKTIIAT IKK

« Hide

References

[1]"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fusaro / DSM 804.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000099 Genomic DNA. Translation: AAZ69849.1.
RefSeqYP_304429.1. NC_007355.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGQ46E43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3626183.
GenomeReviewsGene locus Mbar_A0875 in contig CP000099_GR.
KEGGmba:Mbar_A0875.
NMPDRfig|269797.3.peg.395.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGarNOG08868.
HOGENOMHBG541103.
OMANERVVWH.
PhylomeDBQ46E43.
ProtClustDBPRK05305.

Enzyme and pathway databases

BioCycMBAR269797:MBAR_A0875-MONOMER.

Family and domain databases

HAMAPMF_00664. PS_decarb_type3.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR004428. PtdSer_deCO2ase-related.
[Graphical view]
KOK01613.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00164. PS_decarb_rel. 1 hit.
ProtoNetSearch...

Entry information

Entry namePSD_METBF
AccessionPrimary (citable) accession number: Q46E43
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: September 13, 2005
Last modified: December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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