Q46E27 (Q46E27_METBF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210
EC=2.5.1.19 HAMAP MF_00210

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase HAMAP MF_00210

Gene names

Name:	aroA HAMAP MF_00210
Ordered Locus Names:	Mbar_A0891

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP] EMBL AAZ69865.1

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210 RuleBase RU004116
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family. HAMAP MF_00210 RuleBase RU004164

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00210
Cellular component	Cytoplasm HAMAP MF_00210
Molecular function	Transferase HAMAP MF_00210 EMBL AAZ69865.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q46E27 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 0922FCDE57D7B94C	FASTA	443	47,678
	10 20 30 40 50 60 MKNPIRNRRD LIHMRVSIDK SSIKGEVFAP PSKSYTHRAV TLAALSKEST VRHPLISADT 70 80 90 100 110 120 LATVRASEMF GALVEREEDR LIIHGINGKP NVPDDVIDAA NSGTTLRFMT AVAALTDGIT 130 140 150 160 170 180 VLTGDASLRT RPNGPLLEVL NRLGVKACST RGNERAPLVV KGGLKGQDVS IDGSISSQFI 190 200 210 220 230 240 SALLITCPLA ENSTILSITG KIKSRPYVDI TLEMLELAGV KVHIDDSNGT RFIIPGKQKY 250 260 270 280 290 300 DFKDYTVPGD FSSASYLLAA AAMTDGSEVT VKNLFPSKQG DKVIIETLKQ MGADITWDKE 310 320 330 340 350 360 AGNVTVKGGR QLKAITFDAG ANPDLVPTVA VLAAVAKGTS RIENAEHVRY KETDRLRALA 370 380 390 400 410 420 TELPKLGVDL KEERDSLTIT GGKLHGASVH GWDDHRIVMA LSVAGIVAGN TKIDTTESAS 430 440 ISYPEFFKDM RSLGAKIKDF SKE

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ69865.1.
RefSeq	YP_304445.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46E27.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46E27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3625936.
GenomeReviews	Gene locus Mbar_A0891 in contig CP000099_GR.
KEGG	mba:Mbar_A0891.
NMPDR	fig|269797.3.peg.411.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05032.
HOGENOM	HBG646626.
OMA	RLRIKEC.
PhylomeDB	Q46E27.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q46E27_METBF

Accession

Primary (citable) accession number: Q46E27

Entry history

Integrated into UniProtKB/TrEMBL:	September 13, 2005
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)