ID   AROD_METBF              Reviewed;         242 AA.
AC   Q46DZ7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=3-dehydroquinate dehydratase;
DE            Short=3-dehydroquinase;
DE            EC=4.2.1.10;
DE   AltName: Full=Type I DHQase;
GN   Name=aroD; OrderedLocusNames=Mbar_A0922;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980466; DOI=10.1128/JB.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P.,
RA   Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R.,
RA   Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 3/7.
CC   -!- SIMILARITY: Belongs to the type-I 3-dehydroquinase family.
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DR   EMBL; CP000099; AAZ69895.1; -; Genomic_DNA.
DR   RefSeq; YP_304475.1; -.
DR   GeneID; 3627302; -.
DR   GenomeReviews; CP000099_GR; Mbar_A0922.
DR   KEGG; mba:Mbar_A0922; -.
DR   NMPDR; fig|269797.3.peg.482; -.
DR   HOGENOM; Q46DZ7; -.
DR   OMA; Q46DZ7; IAKLAVM.
DR   BioCyc; MBAR269797:MBAR_A0922-MON; -.
DR   GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   HAMAP; MF_00214; -; 1.
DR   InterPro; IPR018508; 3-dehydroquinate_DH_AS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001381; DHquinase_I.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF01487; DHquinase_I; 1.
DR   ProDom; PD005337; DHquinase_I; 1.
DR   TIGRFAMs; TIGR01093; aroD; 1.
DR   PROSITE; PS01028; DEHYDROQUINASE_I; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Schiff base.
FT   CHAIN         1    242       3-dehydroquinate dehydratase.
FT                                /FTId=PRO_1000043171.
FT   ACT_SITE    135    135       Proton acceptor (By similarity).
FT   ACT_SITE    162    162       Schiff-base intermediate with substrate
FT                                (By similarity).
SQ   SEQUENCE   242 AA;  26245 MW;  465B23712D234BFD CRC64;
     MIHIGQLDLE KKAAVVAVIL EKSLEISRKA AKMGADLLEI RLDLLGIRDL ETAAETIRKV
     KSETGLPVIL TNRSITEGGK WEGKEADRIE LLTNLISLKD GPDAVDIELS AGREARDQVI
     KAAKAHGKTV IVSSHDFSRT PAFQEMKTIL EEAFLAGADI AKLAVMPQSR RDVLNLLRVA
     LDAREAGNAV CTIAMGRLGK HTRVIAPFYG SVLTYAAVNS EVSAAPGQFQ VDEVKKILEL
     LE
//