Q46DC3 (DAPB_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dihydrodipicolinate reductase
Short name=DHPR
EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	Mbar_A1151

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = (S)-2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity HAMAP MF_00102.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADPH binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 263	263	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_0000228407

Sequences

	Sequence		Length	Mass (Da)
	Q46DC3 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: E5C6CAB943AB4EA0	FASTA	263	28,098
	10 20 30 40 50 60 MINVAVLGAC GRMGSLIVEN VINSKDMQLV AAFDISYFGR DAGEFARVGK LGVQISDVKN 70 80 90 100 110 120 LETVLKESKA DVLIDFTAAG ATVVNAPIAA RAGVNLIIGT TGLTPEQRAV IDEAIQEGQV 130 140 150 160 170 180 SAVISPNYSV GVNVFFKIIR EAAKYLADYD IEIIEAHHNQ KKDAPSGTAL RAADIISEAV 190 200 210 220 230 240 GGREYVYGRE GIAPRGKEIG IHGVRAGDIT GDHIVLFAGN SERIEIKHIA HSRQIFAKGA 250 260 VRAAEWVCRQ KPGIYSMDDV LGL

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ70119.1.
RefSeq	YP_304699.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46DC3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46DC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3626284.
GenomeReviews	Gene locus Mbar_A1151 in contig CP000099_GR.
KEGG	mba:Mbar_A1151.
NMPDR	fig|269797.3.peg.1162.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05038.
HOGENOM	HBG594002.
OMA	NTFDVLD.
PhylomeDB	Q46DC3.
ProtClustDB	PRK00048.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A1151-MONOMER.
Family and domain databases
HAMAP	MF_00102. DapB. [Tree]
InterPro	IPR022663. DapB_C. IPR000846. DapB_N. IPR022664. DapB_N_CS. IPR011770. Dihydrodipicolinate_Rdtase. IPR023940. Dihydrodipicolinate_Rdtase_bac. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00215.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
PIRSF	PIRSF000161. DHPR. 1 hit.
TIGRFAMs	TIGR00036. DapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_METBF

Accession

Primary (citable) accession number: Q46DC3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program