Q46D07 (RNP4_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribonuclease P protein component 4
Short name=RNase P component 4
EC=3.1.26.5

Gene names

Name:	rnp4
Ordered Locus Names:	Mbar_A1272

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina barkeri

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends By similarity. HAMAP-Rule MF_00757
Catalytic activity	Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. HAMAP-Rule MF_00757
Subunit structure	Consists of a catalytic RNA component and at least 4 protein subunits Potential.
Sequence similarities	Belongs to the eukaryotic/archaeal RNase P protein component 4 family.

Ontologies

Keywords
Biological process	tRNA processing
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	tRNA 5'-leader removal Inferred from electronic annotation. Source: HAMAP
Molecular_function	ribonuclease P activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 107	107	Ribonuclease P protein component 4 HAMAP-Rule MF_00757		PRO_1000046631

Sequences

	Sequence		Length	Mass (Da)
	Q46D07 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 1E4A5CB36145DEFE	FASTA	107	12,966
	10 20 30 40 50 60 MSRIARKQQK NLIQAIAIQR MWRLFELAKS EYAEHPDRSE RYVQLIRNIS MRNRMSIPRE 70 80 90 100 IKNRICKHCY AFLVPGNNAR YRLKDGYIVV SCQRCGKEMR YPYKKLK

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ70235.1.
RefSeq	YP_304815.1. NC_007355.1.
3D structure databases
HSSP	HSSP built from PDB template 1X0T based on UniProtKB O59248.
ProteinModelPortal	Q46D07.
ModBase	Search...
Protein-protein interaction databases
STRING	269797.Mbar_A1272.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ70235; AAZ70235; Mbar_A1272.
GeneID	3627759.
KEGG	mba:Mbar_A1272.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2023.
HOGENOM	HOG000230709.
KO	K03540.
OMA	PRKWKRR.
ProtClustDB	CLSK811662.
Enzyme and pathway databases
BioCyc	MBAR269797:GHUW-1344-MONOMER.
Family and domain databases
HAMAP	MF_00757. RNase_P_4.
InterPro	IPR016432. RNase_P_comp-4. IPR007175. Rpr2. [Graphical view]
PANTHER	PTHR14742. PTHR14742. 1 hit.
Pfam	PF04032. Rpr2. 1 hit. [Graphical view]
PIRSF	PIRSF004878. RNase_P_4. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RNP4_METBF

Accession

Primary (citable) accession number: Q46D07

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program