ID   IDI2_METBF              Reviewed;         365 AA.
AC   Q46CL4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   16-JUN-2009, entry version 29.
DE   RecName: Full=Isopentenyl-diphosphate delta-isomerase;
DE            Short=IPP isomerase;
DE            EC=5.3.3.2;
DE   AltName: Full=Isopentenyl pyrophosphate isomerase;
GN   Name=fni; OrderedLocusNames=Mbar_A1419;
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16980466; DOI=10.1128/JB.00810-06;
RA   Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P.,
RA   Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R.,
RA   Sowers K.R.;
RT   "The Methanosarcina barkeri genome: comparative analysis with
RT   Methanosarcina acetivorans and Methanosarcina mazei reveals extensive
RT   rearrangement within methanosarcinal genomes.";
RL   J. Bacteriol. 188:7922-7931(2006).
CC   -!- FUNCTION: Catalyzes the 1,3-allylic rearrangement of the
CC       homoallylic substrate isopentenyl (IPP) to its allylic isomer,
CC       dimethylallyl diphosphate (DMAPP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: Isopentenyl diphosphate = dimethylallyl
CC       diphosphate.
CC   -!- COFACTOR: FMN (By similarity).
CC   -!- COFACTOR: NADPH (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the IPP isomerase type 2 family.
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DR   EMBL; CP000099; AAZ70378.1; -; Genomic_DNA.
DR   RefSeq; YP_304958.1; -.
DR   GeneID; 3627455; -.
DR   GenomeReviews; CP000099_GR; Mbar_A1419.
DR   KEGG; mba:Mbar_A1419; -.
DR   NMPDR; fig|269797.3.peg.1402; -.
DR   HOGENOM; Q46CL4; -.
DR   OMA; Q46CL4; AMGVGSQ.
DR   BioCyc; MBAR269797:MBAR_A1419-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0004452; F:isopentenyl-diphosphate delta-isomerase act...; IEA:HAMAP.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00354; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR000262; FMN-dep_DH.
DR   InterPro; IPR011179; IPdP_isomerase.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   PANTHER; PTHR10578:SF3; IPdP_isomerase; 1.
DR   Pfam; PF01070; FMN_dh; 1.
DR   PIRSF; PIRSF003314; IPP_isomerase; 1.
DR   TIGRFAMs; TIGR02151; IPP_isom_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Flavoprotein; FMN; Isomerase;
KW   Isoprene biosynthesis; NADP.
FT   CHAIN         1    365       Isopentenyl-diphosphate delta-isomerase.
FT                                /FTId=PRO_0000229518.
SQ   SEQUENCE   365 AA;  38772 MW;  329B355875BEB285 CRC64;
     MISTTSKRKI EHLKLCAESP VESRKVSAGF EDVTLIHRAL PELDMDKLNL SIDFLGKRLQ
     APFLIASITG GHPDTTPVNA ALAAAAEELG IGMGVGSQRA AIDDPTQEES FRVVREKAPT
     AFIYGNVGAA QIRQYGVDGV EKLIEMIDAD ALAIHLNFLQ EAIQPEGDRD ATGCLDMIKE
     ICSVLGKPVI IKETGAGISR EDSILLQKAG VSAIDVGGAG GTSWAGVEVY RARKSGDYAS
     EHLGELFWDF GIPTVASIIE SRVSLPIIAT GGIRTGIDIA KSIALGASAA SAALPFVGPA
     LEGKESVVRV LSRMLDEFRI AMFLCGCANI QDLRNAPVVV TGWTLEYLGQ RGFNVKDYAI
     AGDSF
//