Q46CL4 (IDI2_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Isopentenyl-diphosphate delta-isomerase
Short name=IPP isomerase
EC=5.3.3.2

Alternative name(s):
Isopentenyl pyrophosphate isomerase

Gene names

Name:	fni
Ordered Locus Names:	Mbar_A1419

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	365 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) By similarity. HAMAP MF_00354
Catalytic activity	Isopentenyl diphosphate = dimethylallyl diphosphate. HAMAP MF_00354
Cofactor	FMN By similarity. HAMAP MF_00354 NADPH By similarity. HAMAP MF_00354
Subcellular location	Cytoplasm By similarity HAMAP MF_00354.
Sequence similarities	Belongs to the IPP isomerase type 2 family.

Ontologies

Keywords
Biological process	Isoprene biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein NADP
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro isopentenyl-diphosphate delta-isomerase activity Inferred from electronic annotation. Source: EC oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 365	365	Isopentenyl-diphosphate delta-isomerase HAMAP MF_00354		PRO_0000229518

Sequences

	Sequence		Length	Mass (Da)
	Q46CL4 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 329B355875BEB285	FASTA	365	38,772
	10 20 30 40 50 60 MISTTSKRKI EHLKLCAESP VESRKVSAGF EDVTLIHRAL PELDMDKLNL SIDFLGKRLQ 70 80 90 100 110 120 APFLIASITG GHPDTTPVNA ALAAAAEELG IGMGVGSQRA AIDDPTQEES FRVVREKAPT 130 140 150 160 170 180 AFIYGNVGAA QIRQYGVDGV EKLIEMIDAD ALAIHLNFLQ EAIQPEGDRD ATGCLDMIKE 190 200 210 220 230 240 ICSVLGKPVI IKETGAGISR EDSILLQKAG VSAIDVGGAG GTSWAGVEVY RARKSGDYAS 250 260 270 280 290 300 EHLGELFWDF GIPTVASIIE SRVSLPIIAT GGIRTGIDIA KSIALGASAA SAALPFVGPA 310 320 330 340 350 360 LEGKESVVRV LSRMLDEFRI AMFLCGCANI QDLRNAPVVV TGWTLEYLGQ RGFNVKDYAI AGDSF

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ70378.1.
RefSeq	YP_304958.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q46CL4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q46CL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3627455.
GenomeReviews	Gene locus Mbar_A1419 in contig CP000099_GR.
KEGG	mba:Mbar_A1419.
NMPDR	fig|269797.3.peg.1402.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG04310.
HOGENOM	HBG354479.
OMA	GSQRAAI.
ProtClustDB	PRK05437.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A1419-MONOMER.
Family and domain databases
HAMAP	MF_00354. Idi_2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR000262. FMN-dep_DH. IPR011179. IPdP_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01823.
PANTHER	PTHR10578:SF3. IPdP_isomerase. 1 hit.
Pfam	PF01070. FMN_dh. 2 hits. [Graphical view]
PIRSF	PIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMs	TIGR02151. IPP_isom_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IDI2_METBF

Accession

Primary (citable) accession number: Q46CL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program