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Q46C14

- HPRT_METBF

UniProt

Q46C14 - HPRT_METBF

Protein

Hypoxanthine/guanine phosphoribosyltransferase

Gene

hpt

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis.UniRule annotation

    Catalytic activityi

    IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
    GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanine phosphoribosyltransferase activity Source: UniProtKB-EC
    2. hypoxanthine phosphoribosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. IMP salvage Source: UniProtKB-UniPathway
    2. purine ribonucleoside salvage Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Purine salvage

    Enzyme and pathway databases

    BioCyciMBAR269797:GHUW-1671-MONOMER.
    UniPathwayiUPA00591; UER00648.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hypoxanthine/guanine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.8UniRule annotation)
    Short name:
    HGPRTaseUniRule annotation
    Gene namesi
    Name:hptUniRule annotation
    Ordered Locus Names:Mbar_A1633
    OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
    Taxonomic identifieri269797 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000008156: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 190190Hypoxanthine/guanine phosphoribosyltransferasePRO_0000415481Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269797.Mbar_A1633.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46C14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0503.
    HOGENOMiHOG000228520.
    KOiK00759.
    OMAiIATDIPY.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01467. Hypx_phosphoribosyltr.
    InterProiIPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    PROSITEiPS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46C14-1 [UniParc]FASTAAdd to Basket

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    MLEKLKTSLI NSPVIKRGEY NYFIHPISDG VPSIDPHMVE EIAEYILQIT    50
    DIKKVDTILT IEAMGIPVAN ALSLKTGIPL TIVRKRPYFL EGEVELSQRT 100
    GYSKGALYIN GLKKGDRVII VDDVISTGGT LIALVKALKT IGVEIQDVIS 150
    VIGRGTGYLQ LKELGVEPKI LVTIDVSEKG VEIKNVFGNE 190
    Length:190
    Mass (Da):20,788
    Last modified:September 13, 2005 - v1
    Checksum:i0022ADF92AAB288B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ70578.1.
    RefSeqiWP_011306624.1. NC_007355.1.
    YP_305158.1. NC_007355.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ70578; AAZ70578; Mbar_A1633.
    GeneIDi3627332.
    KEGGimba:Mbar_A1633.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ70578.1 .
    RefSeqi WP_011306624.1. NC_007355.1.
    YP_305158.1. NC_007355.1.

    3D structure databases

    ProteinModelPortali Q46C14.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269797.Mbar_A1633.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ70578 ; AAZ70578 ; Mbar_A1633 .
    GeneIDi 3627332.
    KEGGi mba:Mbar_A1633.

    Phylogenomic databases

    eggNOGi COG0503.
    HOGENOMi HOG000228520.
    KOi K00759.
    OMAi IATDIPY.

    Enzyme and pathway databases

    UniPathwayi UPA00591 ; UER00648 .
    BioCyci MBAR269797:GHUW-1671-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01467. Hypx_phosphoribosyltr.
    InterProi IPR026597. HGPRTase-like.
    IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    PROSITEi PS00103. PUR_PYR_PR_TRANSFER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
      Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
      J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fusaro / DSM 804.

    Entry informationi

    Entry nameiHPRT_METBF
    AccessioniPrimary (citable) accession number: Q46C14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2012
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3