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Protein

Digeranylgeranylglyceryl phosphate synthase

Gene

Mbar_A1863

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate = diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-1906-MONOMER.
UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Digeranylgeranylglyceryl phosphate synthaseUniRule annotation (EC:2.5.1.42UniRule annotation)
Short name:
DGGGP synthaseUniRule annotation
Short name:
DGGGPSUniRule annotation
Alternative name(s):
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthaseUniRule annotation
Geranylgeranylglycerol-phosphate geranylgeranyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Mbar_A1863
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721HelicalUniRule annotationAdd
BLAST
Transmembranei50 – 7021HelicalUniRule annotationAdd
BLAST
Transmembranei106 – 12621HelicalUniRule annotationAdd
BLAST
Transmembranei141 – 16121HelicalUniRule annotationAdd
BLAST
Transmembranei163 – 18321HelicalUniRule annotationAdd
BLAST
Transmembranei221 – 24121HelicalUniRule annotationAdd
BLAST
Transmembranei243 – 26321HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Digeranylgeranylglyceryl phosphate synthasePRO_0000350710Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A1863.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiMRIGNAV.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46BD9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSASVRTYLE IMRYENCLMA GFAAIIGTLI AFNILTSNAP SSYSPGEFPL
60 70 80 90 100
FSSVLIFLAV FLVAGAGNAI NDYFDVRIDS INRPDRPIPS GRMKLKEALY
110 120 130 140 150
FSYTLFALGT LLAFSINPIC GVIALFNSLV LIFYAKTLKG TPLLGNLSIG
160 170 180 190 200
YLTGSSFLFG ASVFGLEGLK ALFVLFLLAA LAITAREIVK DIEDMEGDKM
210 220 230 240 250
EGADTLPLRV GAKKASYLAA LIGFLAVIFS PLPYHLSMLG LRYLYLVLLA
260 270 280
DLGFLAAIYQ LLARNNPTKS SKMFKIAMFF ALIAFIAGV
Length:289
Mass (Da):31,348
Last modified:September 13, 2005 - v1
Checksum:i978F829A9EEABE68
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ70803.1.
RefSeqiWP_011306849.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ70803; AAZ70803; Mbar_A1863.
GeneIDi3624565.
KEGGimba:Mbar_A1863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ70803.1.
RefSeqiWP_011306849.1. NC_007355.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269797.Mbar_A1863.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ70803; AAZ70803; Mbar_A1863.
GeneIDi3624565.
KEGGimba:Mbar_A1863.

Phylogenomic databases

eggNOGiarCOG00476. Archaea.
COG0382. LUCA.
HOGENOMiHOG000152645.
KOiK17105.
OMAiMRIGNAV.

Enzyme and pathway databases

UniPathwayiUPA00940.
BioCyciMBAR269797:GHUW-1906-MONOMER.

Family and domain databases

HAMAPiMF_01286. DGGGP_synth. 1 hit.
InterProiIPR023547. DGGGP_synth.
IPR000537. UbiA_prenyltransferase.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDGGGP_METBF
AccessioniPrimary (citable) accession number: Q46BD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 13, 2005
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.