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Q46BA3

- DNLI2_METBF

UniProt

Q46BA3 - DNLI2_METBF

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Protein

DNA ligase 2

Gene
lig2, Mbar_A1899
Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATP By similarity
Active sitei256 – 2561N6-AMP-lysine intermediate By similarity
Binding sitei261 – 2611ATP By similarity
Binding sitei276 – 2761ATP By similarity
Binding sitei306 – 3061ATP By similarity
Binding sitei346 – 3461ATP By similarity
Binding sitei425 – 4251ATP By similarity
Binding sitei431 – 4311ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-1942-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene namesi
Name:lig2
Ordered Locus Names:Mbar_A1899
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000008156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568DNA ligase 2UniRule annotationPRO_1000049868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A1899.

Structurei

3D structure databases

ProteinModelPortaliQ46BA3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46BA3-1 [UniParc]FASTAAdd to Basket

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MTSFREFAET CQAIEKISST IDTTSRVADL LKKVDVEELP IATHFIMSEV    50
FPAWSGEQLG IGTSLLYVSL SKASGMPVKS IESLIRTTGD IGDTALLILK 100
EKRKNQVTFS SFFEEQPELS ITEVYNRFKI ASEASGKGSQ DIKIKNLQFL 150
FTSSTPREAK YISRLALEEL RIGVGEGVVR DAIAKAFSVP VDVVEHAFMV 200
TNDLGIVAAT AKDGGVEALE SLGIEINRPI KMMLSQISPD IVADIKEMKE 250
AAIEWKFDGA RVQVHKAGDS VMLFSRKLEN VTNSLPDLVE IIRKHVKAES 300
AILDGEAVAV DENGRPRAFQ EILKRFRRKY DVEEKALGIP IQLNLFDIMY 350
LNGKTLIDLP LIERRKALES CVESSVEDSK SISVDKQVIT GDLDLIEKIY 400
KEALDAGHEG VMVKNPNSFY SPGKRGKNWL KKKPLMETLD LVVVGAEWGF 450
GRRANLLGSY TVACYDPKTL RFLQVGKVGT GLTDDQLKEL TEILSGLMEG 500
GEAGGIFAIR PKIVLEIAFE EIQKSPNYDS GFALRFPRFI RIRDDKDPEE 550
ADTIQRIGKV YSQQLKRL 568
Length:568
Mass (Da):63,176
Last modified:September 13, 2005 - v1
Checksum:iCF22D6D1E1A08B95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ70839.1.
RefSeqiWP_011306885.1. NC_007355.1.
YP_305419.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ70839; AAZ70839; Mbar_A1899.
GeneIDi3624300.
KEGGimba:Mbar_A1899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ70839.1 .
RefSeqi WP_011306885.1. NC_007355.1.
YP_305419.1. NC_007355.1.

3D structure databases

ProteinModelPortali Q46BA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269797.Mbar_A1899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ70839 ; AAZ70839 ; Mbar_A1899 .
GeneIDi 3624300.
KEGGi mba:Mbar_A1899.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MBAR269797:GHUW-1942-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
    Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
    J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fusaro / DSM 804.

Entry informationi

Entry nameiDNLI2_METBF
AccessioniPrimary (citable) accession number: Q46BA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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