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Q46BA3

- DNLI2_METBF

UniProt

Q46BA3 - DNLI2_METBF

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Protein

DNA ligase 2

Gene

lig2

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATPUniRule annotation
Active sitei256 – 2561N6-AMP-lysine intermediateUniRule annotation
Binding sitei261 – 2611ATPUniRule annotation
Binding sitei276 – 2761ATPUniRule annotation
Binding sitei306 – 3061ATPUniRule annotation
Binding sitei346 – 3461ATPUniRule annotation
Binding sitei425 – 4251ATPUniRule annotation
Binding sitei431 – 4311ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBAR269797:GHUW-1942-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2UniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2UniRule annotation
Gene namesi
Name:lig2UniRule annotation
Ordered Locus Names:Mbar_A1899
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000008156: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568DNA ligase 2PRO_1000049868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A1899.

Structurei

3D structure databases

ProteinModelPortaliQ46BA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46BA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSFREFAET CQAIEKISST IDTTSRVADL LKKVDVEELP IATHFIMSEV
60 70 80 90 100
FPAWSGEQLG IGTSLLYVSL SKASGMPVKS IESLIRTTGD IGDTALLILK
110 120 130 140 150
EKRKNQVTFS SFFEEQPELS ITEVYNRFKI ASEASGKGSQ DIKIKNLQFL
160 170 180 190 200
FTSSTPREAK YISRLALEEL RIGVGEGVVR DAIAKAFSVP VDVVEHAFMV
210 220 230 240 250
TNDLGIVAAT AKDGGVEALE SLGIEINRPI KMMLSQISPD IVADIKEMKE
260 270 280 290 300
AAIEWKFDGA RVQVHKAGDS VMLFSRKLEN VTNSLPDLVE IIRKHVKAES
310 320 330 340 350
AILDGEAVAV DENGRPRAFQ EILKRFRRKY DVEEKALGIP IQLNLFDIMY
360 370 380 390 400
LNGKTLIDLP LIERRKALES CVESSVEDSK SISVDKQVIT GDLDLIEKIY
410 420 430 440 450
KEALDAGHEG VMVKNPNSFY SPGKRGKNWL KKKPLMETLD LVVVGAEWGF
460 470 480 490 500
GRRANLLGSY TVACYDPKTL RFLQVGKVGT GLTDDQLKEL TEILSGLMEG
510 520 530 540 550
GEAGGIFAIR PKIVLEIAFE EIQKSPNYDS GFALRFPRFI RIRDDKDPEE
560
ADTIQRIGKV YSQQLKRL
Length:568
Mass (Da):63,176
Last modified:September 13, 2005 - v1
Checksum:iCF22D6D1E1A08B95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ70839.1.
RefSeqiWP_011306885.1. NC_007355.1.
YP_305419.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ70839; AAZ70839; Mbar_A1899.
GeneIDi3624300.
KEGGimba:Mbar_A1899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000099 Genomic DNA. Translation: AAZ70839.1 .
RefSeqi WP_011306885.1. NC_007355.1.
YP_305419.1. NC_007355.1.

3D structure databases

ProteinModelPortali Q46BA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 269797.Mbar_A1899.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ70839 ; AAZ70839 ; Mbar_A1899 .
GeneIDi 3624300.
KEGGi mba:Mbar_A1899.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MBAR269797:GHUW-1942-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
    Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
    J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Fusaro / DSM 804.

Entry informationi

Entry nameiDNLI2_METBF
AccessioniPrimary (citable) accession number: Q46BA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3