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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei635ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Mbar_A2048
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093701 – 966Leucine--tRNA ligaseAdd BLAST966

Proteomic databases

PRIDEiQ46AW0

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A2048

Structurei

3D structure databases

ProteinModelPortaliQ46AW0
SMRiQ46AW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 51"HIGH" regionAdd BLAST11
Motifi632 – 636"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
HOGENOMiHOG000216620
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q46AW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQDYKPHEI EKKWQKKWDE SQIFQAEPDK REKFFITIPY PYLNGNLHAG
60 70 80 90 100
HTRTFTIGDV VARHKRMLGY NVLYPMGFHV TGTPIVGLAE LIANRDPQTM
110 120 130 140 150
DVYERLHGIP GDILPTLDTP EKIVDYFKRE SEKAMRNIGY SIDWRRKFTT
160 170 180 190 200
TDPTYKKFIE WQYIRLGEKG LIVKGSHPVK WCPNDNNPVE DHDILYGEEA
210 220 230 240 250
TIVEYTLIKF RYKDLVLPCA TLRPETTYGV TNLWVNPDVT YVKAKVTLDG
260 270 280 290 300
NEEFWVVSKE AFRKLTFTDR TVEYIEDVPA KSIIGIKLTN PVTDDEVISL
310 320 330 340 350
PASFVRPENG SGIVMSVPAH APFDYLALRD LYDVDLSEYG ITEDLRKIKL
360 370 380 390 400
ISLIKVPEFG EFPAKEIVES MGITSQKDPK AEEATKIVYR REFHGGVLKE
410 420 430 440 450
ITGKYEGQAV SKIKDILTRD FISSNTGETF YEFSEPVVCR CGTPCVVNMV
460 470 480 490 500
KGQWFLNYSN PEWKAKVYKC LAQMRIVPEE YRVEFENKID WLKDKACARR
510 520 530 540 550
KGLGTHLPFD KEWLIESLGD STIYMSYYII ARFIENGELK IENLTLSFFD
560 570 580 590 600
YVLLGKGDSA AASADTGLSP ELLEEIRRHF NYWYPVDLRS SGKDLVPNHL
610 620 630 640 650
LFFLFHHVAL FEEDKWPKAL AVNGFVSLEG QKMSKSKGPI LTMESAVSKY
660 670 680 690 700
GADITRMYIL STAEQTQDAD WQRTGIESAR RQVDRFYSFA KGVIESGKRA
710 720 730 740 750
DLSTELKQID RWILSRIQNY IRDTNSALYS IQTREAIQNS FFLLQNDVKW
760 770 780 790 800
YQRRGGETLL YYVLDNWVRL MAPFTPHLCE EIWEAMGHKD PVSLAQYPLY
810 820 830 840 850
NEGLIDDGAE LAEEMIKGTL EDVEEIIRVT KMTPQKVHLY TAPTWKAEAI
860 870 880 890 900
RCACEMQLEC SLEVGNLIKK LMANPDLKRF GKEIPKFVQK IVPEFKSGSS
910 920 930 940 950
DRYEILTGPD IDEQALLKES ISFLEKEIGC SVEVHSADSP AFDPEKKARF
960
AEPLRPAIYI EGKKKE
Length:966
Mass (Da):111,095
Last modified:September 13, 2005 - v1
Checksum:iB9AD29D5E713058E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA Translation: AAZ70982.1
RefSeqiWP_011307028.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ70982; AAZ70982; Mbar_A2048
GeneIDi3625563
KEGGimba:Mbar_A2048

Similar proteinsi

Entry informationi

Entry nameiSYL_METBF
AccessioniPrimary (citable) accession number: Q46AW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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