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Q46AS7

- RIBL_METBF

UniProt

Q46AS7 - RIBL_METBF

Protein

FAD synthase

Gene

ribL

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.UniRule annotation

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 102ATPUniRule annotation
    Nucleotide bindingi14 – 174ATPUniRule annotation
    Nucleotide bindingi90 – 934ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. FMN adenylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-HAMAP
    2. FMN metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMBAR269797:GHUW-2130-MONOMER.
    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    FAD synthaseUniRule annotation (EC:2.7.7.2UniRule annotation)
    Alternative name(s):
    FMN adenylyltransferaseUniRule annotation
    Flavin adenine dinucleotide synthaseUniRule annotation
    Gene namesi
    Name:ribLUniRule annotation
    Ordered Locus Names:Mbar_A2084
    OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
    Taxonomic identifieri269797 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000008156: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139FAD synthasePRO_0000406269Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi269797.Mbar_A2084.

    Structurei

    3D structure databases

    ProteinModelPortaliQ46AS7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the archaeal FAD synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0615.
    HOGENOMiHOG000284153.
    KOiK14656.
    OMAiIVLGHDQ.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_02115. FAD_synth_arch.
    InterProiIPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01467. CTP_transf_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q46AS7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRILATGTF DLLHPGHIYF LTQARALGDE LFVIVARDSN VTHKPKPIVS    50
    EEQRLEMVNA LGIVDKALLG SEKDMFEPLK HIRPDIIALG YDQRFNAENL 100
    EEELAKRGLP ANVVRIPLSK ECPLCSTGAI IKEVLKRYG 139
    Length:139
    Mass (Da):15,549
    Last modified:September 13, 2005 - v1
    Checksum:iF7455CC2C92CB265
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ71015.1.
    RefSeqiWP_011307061.1. NC_007355.1.
    YP_305595.1. NC_007355.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ71015; AAZ71015; Mbar_A2084.
    GeneIDi3626479.
    KEGGimba:Mbar_A2084.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000099 Genomic DNA. Translation: AAZ71015.1 .
    RefSeqi WP_011307061.1. NC_007355.1.
    YP_305595.1. NC_007355.1.

    3D structure databases

    ProteinModelPortali Q46AS7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269797.Mbar_A2084.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ71015 ; AAZ71015 ; Mbar_A2084 .
    GeneIDi 3626479.
    KEGGi mba:Mbar_A2084.

    Phylogenomic databases

    eggNOGi COG0615.
    HOGENOMi HOG000284153.
    KOi K14656.
    OMAi IVLGHDQ.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .
    BioCyci MBAR269797:GHUW-2130-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_02115. FAD_synth_arch.
    InterProi IPR004821. Cyt_trans-like.
    IPR024902. FAD_synth_RibL.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01467. CTP_transf_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
      Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
      J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Fusaro / DSM 804.

    Entry informationi

    Entry nameiRIBL_METBF
    AccessioniPrimary (citable) accession number: Q46AS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3