Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

NAD kinase

Gene

nadK

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei68Proton acceptorUniRule annotation1
Binding sitei73NADUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei164NADUniRule annotation1
Binding sitei166NADUniRule annotation1
Binding sitei201NAD; via carbonyl oxygenUniRule annotation1
Binding sitei236NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi68 – 69NADUniRule annotation2
Nucleotide bindingi136 – 137NADUniRule annotation2
Nucleotide bindingi177 – 182NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Mbar_A2191
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002297191 – 275NAD kinaseAdd BLAST275

Proteomic databases

PRIDEiQ46AH3

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A2191

Structurei

3D structure databases

ProteinModelPortaliQ46AH3
SMRiQ46AH3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q46AH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKIGISA RCDRPEIIGK VREILAHFSS RVQIFVATPT AEVLGMEGTP
60 70 80 90 100
VERMREEGVE LIISVGGDGT VLRNIAKMKD PLPILGINMG TLGFLVDVEP
110 120 130 140 150
EDALETIEEV LYGFSYSDRM RVDVFLNGEM LETATNEIAI MSAKPAKIIQ
160 170 180 190 200
FEVYVGDCLL DSMRADGVVF ATPTGSTAYA MSAGGPIISP RVNAIVVVPV
210 220 230 240 250
APFKLSSRPW VIPSDSEITI RLSAPKKEAV IAIDGQKSYR IKLDDVVKLK
260 270
KSRFPARFVR ISDTCFYERV QRKLT
Length:275
Mass (Da):30,223
Last modified:September 13, 2005 - v1
Checksum:i3FFB329FA1A00E04
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA Translation: AAZ71119.1
RefSeqiWP_011307165.1, NC_007355.1

Genome annotation databases

EnsemblBacteriaiAAZ71119; AAZ71119; Mbar_A2191
GeneIDi3626067
KEGGimba:Mbar_A2191

Similar proteinsi

Entry informationi

Entry nameiNADK_METBF
AccessioniPrimary (citable) accession number: Q46AH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health