ID   Q46AF2_METBF            Unreviewed;       574 AA.
AC   Q46AF2;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=2-oxoacid ferredoxin oxidoreductase, subunit alpha {ECO:0000313|EMBL:AAZ71140.1};
GN   OrderedLocusNames=Mbar_A2214 {ECO:0000313|EMBL:AAZ71140.1};
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ71140.1};
RN   [1] {ECO:0000313|EMBL:AAZ71140.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fusaro {ECO:0000313|EMBL:AAZ71140.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RT   "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000099; AAZ71140.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q46AF2; -.
DR   STRING; 269797.Mbar_A2214; -.
DR   PaxDb; 269797-Mbar_A2214; -.
DR   KEGG; mba:Mbar_A2214; -.
DR   eggNOG; arCOG01606; Archaea.
DR   HOGENOM; CLU_017038_1_0_2; -.
DR   OrthoDB; 31112at2157; -.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR022367; 2-oxoacid/accept_OxRdtase_asu.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   NCBIfam; TIGR03710; OAFO_sf; 1.
DR   PANTHER; PTHR32154:SF20; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA; 1.
DR   PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          11..172
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          206..445
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
SQ   SEQUENCE   574 AA;  64255 MW;  DE933B18296D6EB9 CRC64;
     MEYTLRVGGE AGQGLQTIGG ALAQVFSKIG FHVFTHQDYM SRVRGGHNFY QIRFSEKEIS
     ASRDMVDILL ALDLDTIEIH RKSVRDEGFI LYDSEITKKK FEEPEFIDIP FKKIALDVGK
     KSVMANTVAT GAALGILDLG LETFRNVLKK AFEKKGDEVI QGNIACAEAG YNYARKNCPR
     CEAPEIREPE NRGLMLIDGV NAIGMGALMS GCKFYSGYPM TPSTGILNYM ASRAEEYNLV
     VEQVEDEISA INMAIGASFA GVRAMTGTSG GGFALMVEGL SLAGMTETPI VIAEMQRPGP
     ATGLPTRTEQ ADLLFVLYAA HGEFPRVIFE PGDPKQAFYL TNKAFELAEK YQIPVFIQSD
     QYLGDTEWTY EKFDLENIIY NDYRLREKDL EGVEVYKRFK YSSTGISLLA VPGEAGKHLV
     VVDSDEHDEE GHIIEDSETR IKMVQKRMLK KLPLIKKEID PPLLYGDSSP KIVLVGRGST
     YGVIKEVVDT ISKDHKVAMM HFSQVYPLPE RDKFDYIELL ENADLTICIE NTATGQFAKL
     MRAETGFEFT HQILRYDGRP FTIENLKEEL HAYI
//