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Q469A3 (CAPPA_METBF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31
Gene names
Name:ppcA
Ordered Locus Names:Mbar_A2632
OrganismMethanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]
Taxonomic identifier269797 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina ›

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_01904

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_01904

Cofactor

Magnesium By similarity.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the PEPCase type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Phosphoenolpyruvate carboxylase HAMAP-Rule MF_01904
PRO_0000309603

Sequences

Sequence LengthMass (Da)Tools
Q469A3 [UniParc].

Last modified September 13, 2005. Version 1.
Checksum: A08490FAE19B6E42

FASTA52658,068
        10         20         30         40         50         60 
MSRKTVFPKV MCTQHPDSAS KYIATQEEPG EAIEAAQIFG CDEYMPDYEG KATPYHQNVQ 

        70         80         90        100        110        120 
VVSKFIEETD LIPGKDIIIT PRAPSAVQEN QFRQLMVMMS IAEANYNALE YSDVQAINEF 

       130        140        150        160        170        180 
VHPMTDSVRE IIGAQQHMVD VSELAKKEFG FSMEVPCIIP LIEDAPALLH AKELAENTLF 

       190        200        210        220        230        240 
AWKGHFGTVP DKFRVFLGKS DSALSFGHVA STLSCKYAIN GICELNSELD TQTGIIFGAG 

       250        260        270        280        290        300 
TLPFRGHLDL MNAENFFKEY RGVGTITLQS ALRYSHKKGD AESLVKLAKA RLPETPELFS 

       310        320        330        340        350        360 
AEEKEEIINL IGIFGASYSR IIRQLAPTIN RIADLLPQQR DRLMHKGTGG YSRSAPDISG 

       370        380        390        400        410        420 
LVNLCRTDIG KELEASMPAE DLQLPRAIKF TGALYSIGLP PEFIGTGRAL EEAREKLGEA 

       430        440        450        460        470        480 
ACENLLTKYF PSLAGDLNFA SEYLDLNVAS RFLSSECLKE VSKDLDILHG AFALETSPEP 

       490        500        510        520 
SYRILVEMMQ PDLLQAGSRG NCMDEEVSQL VCSTLTKMGK IRKALG

« Hide

References

[1]"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes."
Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R.
J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Fusaro / DSM 804.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000099 Genomic DNA. Translation: AAZ71539.1.
RefSeqYP_306119.1. NC_007355.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING269797.Mbar_A2632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAZ71539; AAZ71539; Mbar_A2632.
GeneID3625651.
KEGGmba:Mbar_A2632.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1892.
HOGENOMHOG000009826.
KOK01595.
OMAMCTQHPD.
ProtClustDBPRK13655.

Enzyme and pathway databases

BioCycMBAR269797:GHUW-2702-MONOMER.

Family and domain databases

HAMAPMF_01904. PEPcase_type2.
InterProIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PIRSFPIRSF006677. UCP006677. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR02751. PEPCase_arch. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCAPPA_METBF
AccessionPrimary (citable) accession number: Q469A3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: September 13, 2005
Last modified: May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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