Q46968 (ECHI_ERWCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-homoserine-lactone synthase
EC=2.3.1.184

Alternative name(s):
Autoinducer synthesis protein EchI

Gene names

Name:

echI

Organism

Erwinia chrysanthemi

Taxonomic identifier

556 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-homoserine lactone), an autoinducer molecule which binds to the EchR transcriptional regulator.
Catalytic activity	An acyl-[acyl-carrier-protein] + S-adenosyl-L-methionine = [acyl-carrier-protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone.
Sequence similarities	Belongs to the autoinducer synthase family.

Ontologies

Keywords
Biological process	Autoinducer synthesis Quorum sensing
Molecular function	Transferase
Gene Ontology (GO)
Biological_process	quorum sensing Inferred from electronic annotation. Source: UniProtKB-KW signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 212	212	Acyl-homoserine-lactone synthase		PRO_0000210883

Sequences

	Sequence		Length	Mass (Da)
	Q46968 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 877250BCD1B8D5D3	FASTA	212	24,789
	10 20 30 40 50 60 MLEIFDVSFS LMSNNKLDEV FTLRKDTFKD RLDWAVNCIN GMEFDEYDNE HTTYLLGVKE 70 80 90 100 110 120 GKVICSVRFI EIKYPNMITG TFYSYFDNLK IPEGNYIESS RFFVDRDRVR NLIGTRNPAC 130 140 150 160 170 180 VTLFLAMINY ARKYHYDGIL TIVSHPMLTL LKRSGWRISI IQQGLSEKQE RIYLLHLPTD 190 200 210 DDSRHALIER ITQMTQAESE QLKTLPLLVP LA

References

[1]	Sebaihia M., Harrison O., Kell C., Minton N., Salmond G.P.C. Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NCPPB 1066.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U45854 Genomic DNA. Translation: AAA86841.1.
3D structure databases
ProteinModelPortal	Q46968.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.630.30. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001690. Autoind_synth. IPR018311. Autoind_synth_CS. [Graphical view]
Pfam	PF00765. Autoind_synth. 1 hit. [Graphical view]
PRINTS	PR01549. AUTOINDCRSYN.
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
PROSITE	PS00949. AUTOINDUCER_SYNTH_1. 1 hit. PS51187. AUTOINDUCER_SYNTH_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ECHI_ERWCH

Accession

Primary (citable) accession number: Q46968

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program