Q46953 (YPJF_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable toxin YpjF

Gene names

Name:	ypjF
Ordered Locus Names:	b2646, JW2627

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures. Might be inactivated by putative antitoxin YfjZ. Ref.3
Sequence similarities	Belongs to the CbtA/YkfI/YpjF toxin family.

Ontologies

Keywords
Molecular function	Toxin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 109	109	Probable toxin YpjF		PRO_0000169288

Sequences

	Sequence		Length	Mass (Da)
	Q46953 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CFF6B952B620C77A	FASTA	109	12,308
	10 20 30 40 50 60 MNTLPATISQ AAKPCLSPVA VWQMLLTRLL EQHYGLTLND TPFSDETVIK EHIDAGITLA 70 80 90 100 DAVNFLVEKY ELVRIDHRGF SWQQQSPYIS VVDILRARRS TGLLKTNVK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"A novel family of Escherichia coli toxin-antitoxin gene pairs." Brown J.M., Shaw K.J. J. Bacteriol. 185:6600-6608(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A TOXIN. Strain: K12 / MG1655 / ATCC 47076.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U36840 Genomic DNA. Translation: AAA79814.1. U00096 Genomic DNA. Translation: AAC75694.1. AP009048 Genomic DNA. Translation: BAE76774.1.
PIR	T08657.
RefSeq	NP_417133.1. NC_000913.2. YP_490867.1. NC_007779.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	511145.b2646.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75694; AAC75694; b2646. BAE76774; BAE76774; BAE76774.
GeneID	12933259. 947131.
KEGG	ecj:Y75_p2593. eco:b2646.
PATRIC	32120687. VBIEscCol129921_2742.
Organism-specific databases
EchoBASE	EB4032.
EcoGene	EG14284. ypjF.
Phylogenomic databases
eggNOG	NOG40316.
HOGENOM	HOG000124769.
OMA	WQEQSPF.
ProtClustDB	CLSK2393437.
Enzyme and pathway databases
BioCyc	EcoCyc:G7381-MONOMER. ECOL316407:JW2627-MONOMER.
Gene expression databases
Genevestigator	Q46953.
Family and domain databases
InterPro	IPR009610. DUF1219. [Graphical view]
Pfam	PF06755. DUF1219. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YPJF_ECOLI

Accession

Primary (citable) accession number: Q46953
Secondary accession number(s): Q2MAD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program