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Protein

Probable acetyl-CoA acetyltransferase

Gene

yqeF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Acyl-thioester intermediateBy similarity
Active sitei348 – 3481Proton acceptorPROSITE-ProRule annotation
Active sitei378 – 3781Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  • acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC
  • acetyl-CoA C-acyltransferase activity Source: EcoCyc

GO - Biological processi

  • 1-butanol biosynthetic process Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G7464-MONOMER.
ECOL316407:JW5453-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:yqeF
Ordered Locus Names:b2844, JW5453
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13097. yqeF.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Probable acetyl-CoA acetyltransferasePRO_0000206456Add
BLAST

Proteomic databases

EPDiQ46939.
PaxDbiQ46939.

Interactioni

Protein-protein interaction databases

BioGridi4263512. 11 interactions.
DIPiDIP-12853N.
STRINGi511145.b2844.

Structurei

3D structure databases

ProteinModelPortaliQ46939.
SMRiQ46939. Positions 3-391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012238.
InParanoidiQ46939.
KOiK00626.
OMAiESTEKHN.
PhylomeDBiQ46939.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVVIVGAL RTPIGCFRGA LAGHSAVELG SLVVKALIER TGVPAYAVDE
60 70 80 90 100
VILGQVLTAG AGQNPARQSA IKGGLPNSVS AITINDVCGS GLKALHLATQ
110 120 130 140 150
AIQCGEADIV IAGGQENMSR APHVLTDSRT GAQLGNSQLV DSLVHDGLWD
160 170 180 190 200
AFNDYHIGVT AENLAREYGI SRQLQDAYAL SSQQKARAAI DAGRFKDEIV
210 220 230 240 250
PVMTQSNGQT LVVDTDEQPR TDASAEGLAR LNPSFDSLGS VTAGNASSIN
260 270 280 290 300
DGAAAVMMMS EAKARALNLP VLARIRAFAS VGVDPALMGI APVYATRRCL
310 320 330 340 350
ERVGWQLAEV DLIEANEAFA AQALSVGKML EWDERRVNVN GGAIALGHPI
360 370 380 390
GASGCRILVS LVHEMVKRNA RKGLATLCIG GGQGVALTIE RDE
Length:393
Mass (Da):41,019
Last modified:May 30, 2000 - v2
Checksum:iFF21A11064A9B88B
GO

Sequence cautioni

The sequence AAB40491 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40491.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75883.2.
AP009048 Genomic DNA. Translation: BAE76913.1.
PIRiE65067.
RefSeqiNP_417321.2. NC_000913.3.
WP_000656030.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75883; AAC75883; b2844.
BAE76913; BAE76913; BAE76913.
GeneIDi947324.
KEGGiecj:JW5453.
eco:b2844.
PATRICi32121106. VBIEscCol129921_2942.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA. Translation: AAB40491.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75883.2.
AP009048 Genomic DNA. Translation: BAE76913.1.
PIRiE65067.
RefSeqiNP_417321.2. NC_000913.3.
WP_000656030.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46939.
SMRiQ46939. Positions 3-391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263512. 11 interactions.
DIPiDIP-12853N.
STRINGi511145.b2844.

Proteomic databases

EPDiQ46939.
PaxDbiQ46939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75883; AAC75883; b2844.
BAE76913; BAE76913; BAE76913.
GeneIDi947324.
KEGGiecj:JW5453.
eco:b2844.
PATRICi32121106. VBIEscCol129921_2942.

Organism-specific databases

EchoBASEiEB2900.
EcoGeneiEG13097. yqeF.

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012238.
InParanoidiQ46939.
KOiK00626.
OMAiESTEKHN.
PhylomeDBiQ46939.

Enzyme and pathway databases

BioCyciEcoCyc:G7464-MONOMER.
ECOL316407:JW5453-MONOMER.

Miscellaneous databases

PROiQ46939.

Family and domain databases

Gene3Di3.40.47.10. 4 hits.
InterProiIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
PfamiPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEiPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYQEF_ECOLI
AccessioniPrimary (citable) accession number: Q46939
Secondary accession number(s): Q2M9Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.