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Protein

Probable acetyl-CoA acetyltransferase

Gene

yqeF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2 acetyl-CoA = CoA + acetoacetyl-CoA.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Acyl-thioester intermediateBy similarity1
Active sitei348Proton acceptorPROSITE-ProRule annotation1
Active sitei378Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • acetyl-CoA C-acetyltransferase activity Source: UniProtKB-EC
  • acetyl-CoA C-acyltransferase activity Source: EcoCyc

GO - Biological processi

  • 1-butanol biosynthetic process Source: CACAO
  • fatty acid beta-oxidation Source: GO_Central

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciEcoCyc:G7464-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acetyl-CoA acetyltransferase (EC:2.3.1.9)
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene namesi
Name:yqeF
Ordered Locus Names:b2844, JW5453
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13097 yqeF

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002064561 – 393Probable acetyl-CoA acetyltransferaseAdd BLAST393

Proteomic databases

EPDiQ46939
PaxDbiQ46939
PRIDEiQ46939

Interactioni

Protein-protein interaction databases

BioGridi4263512, 12 interactors
DIPiDIP-12853N
STRINGi316385.ECDH10B_3016

Structurei

3D structure databases

ProteinModelPortaliQ46939
SMRiQ46939
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.Curated

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012238
InParanoidiQ46939
KOiK00626
OMAiICPSIAI
PhylomeDBiQ46939

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 4 hits
InterProiView protein in InterPro
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q46939-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDVVIVGAL RTPIGCFRGA LAGHSAVELG SLVVKALIER TGVPAYAVDE
60 70 80 90 100
VILGQVLTAG AGQNPARQSA IKGGLPNSVS AITINDVCGS GLKALHLATQ
110 120 130 140 150
AIQCGEADIV IAGGQENMSR APHVLTDSRT GAQLGNSQLV DSLVHDGLWD
160 170 180 190 200
AFNDYHIGVT AENLAREYGI SRQLQDAYAL SSQQKARAAI DAGRFKDEIV
210 220 230 240 250
PVMTQSNGQT LVVDTDEQPR TDASAEGLAR LNPSFDSLGS VTAGNASSIN
260 270 280 290 300
DGAAAVMMMS EAKARALNLP VLARIRAFAS VGVDPALMGI APVYATRRCL
310 320 330 340 350
ERVGWQLAEV DLIEANEAFA AQALSVGKML EWDERRVNVN GGAIALGHPI
360 370 380 390
GASGCRILVS LVHEMVKRNA RKGLATLCIG GGQGVALTIE RDE
Length:393
Mass (Da):41,019
Last modified:May 30, 2000 - v2
Checksum:iFF21A11064A9B88B
GO

Sequence cautioni

The sequence AAB40491 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29581 Genomic DNA Translation: AAB40491.1 Different initiation.
U00096 Genomic DNA Translation: AAC75883.2
AP009048 Genomic DNA Translation: BAE76913.1
PIRiE65067
RefSeqiNP_417321.2, NC_000913.3
WP_000656030.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75883; AAC75883; b2844
BAE76913; BAE76913; BAE76913
GeneIDi947324
KEGGiecj:JW5453
eco:b2844
PATRICifig|1411691.4.peg.3890

Similar proteinsi

Entry informationi

Entry nameiYQEF_ECOLI
AccessioniPrimary (citable) accession number: Q46939
Secondary accession number(s): Q2M9Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health