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Q46938 (KDUI_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase
EC=5.3.1.17
Alternative name(s):
5-keto-4-deoxyuronate isomerase
DKI isomerase
Gene names
Name:kduI
Synonyms:yqeE
Ordered Locus Names:b2843, JW2811
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate. HAMAP MF_00687

Pathway

Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 4/5. HAMAP MF_00687

Subunit structure

Homohexamer.

Sequence similarities

Belongs to the kduI family.

Ontologies

Keywords
   Molecular functionIsomerase
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processpectin catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytosol

Inferred from direct assay. Source: UniProtKB

   Molecular function4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2782784-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase HAMAP MF_00687
PRO_0000215485

Secondary structure

1 ............................................................. 278
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q46938 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F7CD5C259503CD1A

FASTA27831,076
        10         20         30         40         50         60 
MDVRQSIHSA HAKTLDTQGL RNEFLVEKVF VADEYTMVYS HIDRIIVGGI MPITKTVSVG 

        70         80         90        100        110        120 
GEVGKQLGVS YFLERRELGV INIGGAGTIT VDGQCYEIGH RDALYVGKGA KEVVFASIDT 

       130        140        150        160        170        180 
GTPAKFYYNC APAHTTYPTK KVTPDEVSPV TLGDNLTSNR RTINKYFVPD VLETCQLSMG 

       190        200        210        220        230        240 
LTELAPGNLW NTMPCHTHER RMEVYFYFNM DDDACVFHMM GQPQETRHIV MHNEQAVISP 

       250        260        270 
SWSIHSGVGT KAYTFIWGMV GENQVFDDMD HVAVKDLR

« Hide

References

« Hide 'large scale' references
[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]"Crystallization of 5-keto-4-deoxyuronate isomerase from Escherichia coli."
Dunten P., Jaffe H., Aksamit R.R.
Acta Crystallogr. D 54:678-680(1998) [PubMed: 9761873] [Abstract]
Cited for: CRYSTALLIZATION, PROTEIN SEQUENCE OF 1-20 AND 227-247.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U29581 Genomic DNA. Translation: AAB40490.1.
U00096 Genomic DNA. Translation: AAC75882.1.
AP009048 Genomic DNA. Translation: BAE76912.1.
PIRD65067.
RefSeqNP_417320.1. NC_000913.2.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1X8MX-ray2.60A/B/C/D/E/F2-278[»]
1XRUX-ray1.94A/B1-275[»]
ProteinModelPortalQ46938.
SMRQ46938. Positions 1-277.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-10069N.
IntActQ46938. 4 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000002790; EBESCP00000002790; EBESCG00000002276.
EBESCT00000014597; EBESCP00000013888; EBESCG00000013658.
GeneID947319.
GenomeReviewsGene locus JW2811 in contig AP009048_GR.
Gene locus b2843 in contig U00096_GR.
KEGGecj:JW2811.
eco:b2843.
PATRIC32121104. VBIEscCol129921_2941.

Organism-specific databases

EchoBASEEB2899.
EcoGeneEG13096. kduI.

Phylogenomic databases

eggNOGCOG3717.
GeneTreeEBGT00050000011662.
HOGENOMHBG301328.
OMAAKFYLVS.
PhylomeDBQ46938.
ProtClustDBPRK00924.

Enzyme and pathway databases

BioCycEcoCyc:G7463-MONOMER.
BRENDA5.3.1.17. 2026.

Gene expression databases

GenevestigatorQ46938.

Family and domain databases

HAMAPMF_00687. KduI.
[Tree]
InterProIPR011051. Cupin_RmlC_type.
IPR007045. KduI.
IPR021120. KduI/IolB_isomerase.
[Graphical view]
KOK01815.
PfamPF04962. KduI. 1 hit.
[Graphical view]
PIRSFPIRSF006625. KduI. 1 hit.
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKDUI_ECOLI
AccessionPrimary (citable) accession number: Q46938
Secondary accession number(s): Q2M9Z4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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