Q46927 (YGDL_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein YgdL

Gene names

Name:	ygdL
Ordered Locus Names:	b2812, JW2783

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the HesA/MoeB/ThiF family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	threonylcarbamoyladenosine biosynthetic process Inferred from mutant phenotype PubMed 23242255. Source: EcoCyc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Uncharacterized protein YgdL		PRO_0000120579
Regions
	Transmembrane	237 – 257	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q46927 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D1609BA2224EB300	FASTA	268	28,562
	10 20 30 40 50 60 MSVVISDAWR QRFGGTARLY GEKALQLFAD AHICVVGIGG VGSWAAEALA RTGIGAITLI 70 80 90 100 110 120 DMDDVCVTNT NRQIHALRDN VGLAKAEVMA ERIRQINPEC RVTVVDDFVT PDNVAQYMSV 130 140 150 160 170 180 GYSYVIDAID SVRPKAALIA YCRRNKIPLV TTGGAGGQID PTQIQVTDLA KTIQDPLAAK 190 200 210 220 230 240 LRERLKSDFG VVKNSKGKLG VDCVFSTEAL VYPQSDGTVC AMKATAEGPK RMDCASGFGA 250 260 ATMVTATFGF VAVSHALKKM MAKAARQG

References

[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U29581 Genomic DNA. Translation: AAB40462.1. U00096 Genomic DNA. Translation: AAC75854.1. AP009048 Genomic DNA. Translation: BAE76884.1.
PIR	H65063.
RefSeq	NP_417292.1. NC_000913.2. YP_491020.1. NC_007779.1.
3D structure databases
ProteinModelPortal	Q46927.
SMR	Q46927. Positions 21-199.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q46927. 7 interactions.
STRING	511145.b2812.
Proteomic databases
PaxDb	Q46927.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC75854; AAC75854; b2812. BAE76884; BAE76884; BAE76884.
GeneID	12932133. 947291.
KEGG	ecj:Y75_p2749. eco:b2812.
PATRIC	32121040. VBIEscCol129921_2912.
Organism-specific databases
EchoBASE	EB2893.
EcoGene	EG13084. ygdL.
Phylogenomic databases
eggNOG	COG1179.
HOGENOM	HOG000263839.
OMA	DDVCVSN.
ProtClustDB	PRK15116.
Enzyme and pathway databases
BioCyc	EcoCyc:G7456-MONOMER. ECOL316407:JW2783-MONOMER.
Gene expression databases
Genevestigator	Q46927.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
InterPro	IPR009036. Molybdenum_cofac_synth_MoeB. IPR016040. NAD(P)-bd_dom. IPR000594. ThiF_NAD_FAD-bd. [Graphical view]
Pfam	PF00899. ThiF. 1 hit. [Graphical view]
SUPFAM	SSF69572. MoeB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YGDL_ECOLI

Accession

Primary (citable) accession number: Q46927
Secondary accession number(s): Q2MA22

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program