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Protein

Inner membrane metabolite transport protein YgcS

Gene

ygcS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2771-MONOMER.
ECOL316407:JW5845-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.95. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane metabolite transport protein YgcS
Gene namesi
Name:ygcS
Ordered Locus Names:b2771, JW5845
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13126. ygcS.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 56PeriplasmicSequence analysisAdd BLAST13
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 85CytoplasmicSequence analysis8
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 114PeriplasmicSequence analysis8
Transmembranei115 – 135Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini136 – 142CytoplasmicSequence analysis7
Transmembranei143 – 163Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini164 – 175PeriplasmicSequence analysisAdd BLAST12
Transmembranei176 – 196Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini197 – 253CytoplasmicSequence analysisAdd BLAST57
Transmembranei254 – 274Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini275 – 286PeriplasmicSequence analysisAdd BLAST12
Transmembranei287 – 307Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini308 – 311CytoplasmicSequence analysis4
Transmembranei312 – 332Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini333 – 337PeriplasmicSequence analysis5
Transmembranei338 – 358Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini359 – 369CytoplasmicSequence analysisAdd BLAST11
Transmembranei370 – 390Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini391 – 400PeriplasmicSequence analysis10
Transmembranei401 – 421Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini422 – 445CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504831 – 445Inner membrane metabolite transport protein YgcSAdd BLAST445

Proteomic databases

PaxDbiQ46909.
PRIDEiQ46909.

Interactioni

Protein-protein interaction databases

BioGridi4260743. 157 interactors.
STRINGi511145.b2771.

Structurei

3D structure databases

ProteinModelPortaliQ46909.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C54. Bacteria.
ENOG410XQKC. LUCA.
HOGENOMiHOG000077075.
InParanoidiQ46909.
OMAiTRNIRMI.
PhylomeDBiQ46909.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSPVRMDD LPLNRFHCRI AALTFGAHLT DGYVLGVIGY AIIQLTPAMQ
60 70 80 90 100
LTPFMAGMIG GSALLGLFLG SLVLGWISDH IGRQKIFTFS FLLITLASFL
110 120 130 140 150
QFFATTPEHL IGLRILIGIG LGGDYSVGHT LLAEFSPRRH RGILLGAFSV
160 170 180 190 200
VWTVGYVLAS IAGHHFISEN PEAWRWLLAS AALPALLITL LRWGTPESPR
210 220 230 240 250
WLLRQGRFAE AHAIVHRYFG PHVLLGDEVV TATHKHIKTL FSSRYWRRTA
260 270 280 290 300
FNSVFFVCLV IPWFVIYTWL PTIAQTIGLE DALTASLMLN ALLIVGALLG
310 320 330 340 350
LVLTHLLAHR KFLLGSFLLL AATLVVMACL PSGSSLTLLL FVLFSTTISA
360 370 380 390 400
VSNLVGILPA ESFPTDIRSL GVGFATAMSR LGAAVSTGLL PWVLAQWGMQ
410 420 430 440
VTLLLLATVL LVGFVVTWLW APETKALPLV AAGNVGGANE HSVSV
Length:445
Mass (Da):48,234
Last modified:November 1, 1997 - v2
Checksum:iB59E452721B15774
GO

Sequence cautioni

The sequence AAA69281 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69281.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75813.2.
AP009048 Genomic DNA. Translation: BAE76848.1.
PIRiG65058.
RefSeqiNP_417251.2. NC_000913.3.
WP_001098105.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75813; AAC75813; b2771.
BAE76848; BAE76848; BAE76848.
GeneIDi947238.
KEGGiecj:JW5845.
eco:b2771.
PATRICi32120954. VBIEscCol129921_2869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69281.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75813.2.
AP009048 Genomic DNA. Translation: BAE76848.1.
PIRiG65058.
RefSeqiNP_417251.2. NC_000913.3.
WP_001098105.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46909.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260743. 157 interactors.
STRINGi511145.b2771.

Protein family/group databases

TCDBi2.A.1.1.95. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ46909.
PRIDEiQ46909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75813; AAC75813; b2771.
BAE76848; BAE76848; BAE76848.
GeneIDi947238.
KEGGiecj:JW5845.
eco:b2771.
PATRICi32120954. VBIEscCol129921_2869.

Organism-specific databases

EchoBASEiEB2927.
EcoGeneiEG13126. ygcS.

Phylogenomic databases

eggNOGiENOG4105C54. Bacteria.
ENOG410XQKC. LUCA.
HOGENOMiHOG000077075.
InParanoidiQ46909.
OMAiTRNIRMI.
PhylomeDBiQ46909.

Enzyme and pathway databases

BioCyciEcoCyc:B2771-MONOMER.
ECOL316407:JW5845-MONOMER.

Miscellaneous databases

PROiQ46909.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYGCS_ECOLI
AccessioniPrimary (citable) accession number: Q46909
Secondary accession number(s): Q2MA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.