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Protein

Inner membrane metabolite transport protein YgcS

Gene

ygcS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:B2771-MONOMER

Protein family/group databases

TCDBi2.A.1.1.95 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane metabolite transport protein YgcS
Gene namesi
Name:ygcS
Ordered Locus Names:b2771, JW5845
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13126 ygcS

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 56PeriplasmicSequence analysisAdd BLAST13
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 85CytoplasmicSequence analysis8
Transmembranei86 – 106Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini107 – 114PeriplasmicSequence analysis8
Transmembranei115 – 135Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini136 – 142CytoplasmicSequence analysis7
Transmembranei143 – 163Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini164 – 175PeriplasmicSequence analysisAdd BLAST12
Transmembranei176 – 196Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini197 – 253CytoplasmicSequence analysisAdd BLAST57
Transmembranei254 – 274Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini275 – 286PeriplasmicSequence analysisAdd BLAST12
Transmembranei287 – 307Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini308 – 311CytoplasmicSequence analysis4
Transmembranei312 – 332Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini333 – 337PeriplasmicSequence analysis5
Transmembranei338 – 358Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini359 – 369CytoplasmicSequence analysisAdd BLAST11
Transmembranei370 – 390Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini391 – 400PeriplasmicSequence analysis10
Transmembranei401 – 421Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini422 – 445CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504831 – 445Inner membrane metabolite transport protein YgcSAdd BLAST445

Proteomic databases

PaxDbiQ46909
PRIDEiQ46909

Interactioni

Protein-protein interaction databases

BioGridi4260743, 160 interactors
STRINGi316385.ECDH10B_2939

Structurei

3D structure databases

ProteinModelPortaliQ46909
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C54 Bacteria
ENOG410XQKC LUCA
HOGENOMiHOG000077075
InParanoidiQ46909
OMAiWFVFLRT
PhylomeDBiQ46909

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSPVRMDD LPLNRFHCRI AALTFGAHLT DGYVLGVIGY AIIQLTPAMQ
60 70 80 90 100
LTPFMAGMIG GSALLGLFLG SLVLGWISDH IGRQKIFTFS FLLITLASFL
110 120 130 140 150
QFFATTPEHL IGLRILIGIG LGGDYSVGHT LLAEFSPRRH RGILLGAFSV
160 170 180 190 200
VWTVGYVLAS IAGHHFISEN PEAWRWLLAS AALPALLITL LRWGTPESPR
210 220 230 240 250
WLLRQGRFAE AHAIVHRYFG PHVLLGDEVV TATHKHIKTL FSSRYWRRTA
260 270 280 290 300
FNSVFFVCLV IPWFVIYTWL PTIAQTIGLE DALTASLMLN ALLIVGALLG
310 320 330 340 350
LVLTHLLAHR KFLLGSFLLL AATLVVMACL PSGSSLTLLL FVLFSTTISA
360 370 380 390 400
VSNLVGILPA ESFPTDIRSL GVGFATAMSR LGAAVSTGLL PWVLAQWGMQ
410 420 430 440
VTLLLLATVL LVGFVVTWLW APETKALPLV AAGNVGGANE HSVSV
Length:445
Mass (Da):48,234
Last modified:November 1, 1997 - v2
Checksum:iB59E452721B15774
GO

Sequence cautioni

The sequence AAA69281 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA Translation: AAA69281.1 Different initiation.
U00096 Genomic DNA Translation: AAC75813.2
AP009048 Genomic DNA Translation: BAE76848.1
PIRiG65058
RefSeqiNP_417251.2, NC_000913.3
WP_001098105.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75813; AAC75813; b2771
BAE76848; BAE76848; BAE76848
GeneIDi947238
KEGGiecj:JW5845
eco:b2771
PATRICifig|511145.12.peg.2869

Entry informationi

Entry nameiYGCS_ECOLI
AccessioniPrimary (citable) accession number: Q46909
Secondary accession number(s): Q2MA58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health