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Protein

Inner membrane metabolite transport protein YgcS

Gene

ygcS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2771-MONOMER.
ECOL316407:JW5845-MONOMER.

Protein family/group databases

TCDBi2.A.1.1.95. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane metabolite transport protein YgcS
Gene namesi
Name:ygcS
Ordered Locus Names:b2771, JW5845
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13126. ygcS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2222CytoplasmicSequence analysisAdd
BLAST
Transmembranei23 – 4321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini44 – 5613PeriplasmicSequence analysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 858CytoplasmicSequence analysis
Transmembranei86 – 10621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini107 – 1148PeriplasmicSequence analysis
Transmembranei115 – 13521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini136 – 1427CytoplasmicSequence analysis
Transmembranei143 – 16321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini164 – 17512PeriplasmicSequence analysisAdd
BLAST
Transmembranei176 – 19621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini197 – 25357CytoplasmicSequence analysisAdd
BLAST
Transmembranei254 – 27421Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini275 – 28612PeriplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30721Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini308 – 3114CytoplasmicSequence analysis
Transmembranei312 – 33221Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini333 – 3375PeriplasmicSequence analysis
Transmembranei338 – 35821Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini359 – 36911CytoplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini391 – 40010PeriplasmicSequence analysis
Transmembranei401 – 42121Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini422 – 44524CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Inner membrane metabolite transport protein YgcSPRO_0000050483Add
BLAST

Proteomic databases

PaxDbiQ46909.
PRIDEiQ46909.

Interactioni

Protein-protein interaction databases

BioGridi4260743. 157 interactions.
STRINGi511145.b2771.

Structurei

3D structure databases

ProteinModelPortaliQ46909.
SMRiQ46909. Positions 36-429.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C54. Bacteria.
ENOG410XQKC. LUCA.
HOGENOMiHOG000077075.
InParanoidiQ46909.
OMAiTRNIRMI.
OrthoDBiEOG6SJJKM.
PhylomeDBiQ46909.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46909-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSPVRMDD LPLNRFHCRI AALTFGAHLT DGYVLGVIGY AIIQLTPAMQ
60 70 80 90 100
LTPFMAGMIG GSALLGLFLG SLVLGWISDH IGRQKIFTFS FLLITLASFL
110 120 130 140 150
QFFATTPEHL IGLRILIGIG LGGDYSVGHT LLAEFSPRRH RGILLGAFSV
160 170 180 190 200
VWTVGYVLAS IAGHHFISEN PEAWRWLLAS AALPALLITL LRWGTPESPR
210 220 230 240 250
WLLRQGRFAE AHAIVHRYFG PHVLLGDEVV TATHKHIKTL FSSRYWRRTA
260 270 280 290 300
FNSVFFVCLV IPWFVIYTWL PTIAQTIGLE DALTASLMLN ALLIVGALLG
310 320 330 340 350
LVLTHLLAHR KFLLGSFLLL AATLVVMACL PSGSSLTLLL FVLFSTTISA
360 370 380 390 400
VSNLVGILPA ESFPTDIRSL GVGFATAMSR LGAAVSTGLL PWVLAQWGMQ
410 420 430 440
VTLLLLATVL LVGFVVTWLW APETKALPLV AAGNVGGANE HSVSV
Length:445
Mass (Da):48,234
Last modified:November 1, 1997 - v2
Checksum:iB59E452721B15774
GO

Sequence cautioni

The sequence AAA69281.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69281.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75813.2.
AP009048 Genomic DNA. Translation: BAE76848.1.
PIRiG65058.
RefSeqiNP_417251.2. NC_000913.3.
WP_001098105.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75813; AAC75813; b2771.
BAE76848; BAE76848; BAE76848.
GeneIDi947238.
KEGGiecj:JW5845.
eco:b2771.
PATRICi32120954. VBIEscCol129921_2869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69281.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75813.2.
AP009048 Genomic DNA. Translation: BAE76848.1.
PIRiG65058.
RefSeqiNP_417251.2. NC_000913.3.
WP_001098105.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46909.
SMRiQ46909. Positions 36-429.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260743. 157 interactions.
STRINGi511145.b2771.

Protein family/group databases

TCDBi2.A.1.1.95. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiQ46909.
PRIDEiQ46909.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75813; AAC75813; b2771.
BAE76848; BAE76848; BAE76848.
GeneIDi947238.
KEGGiecj:JW5845.
eco:b2771.
PATRICi32120954. VBIEscCol129921_2869.

Organism-specific databases

EchoBASEiEB2927.
EcoGeneiEG13126. ygcS.

Phylogenomic databases

eggNOGiENOG4105C54. Bacteria.
ENOG410XQKC. LUCA.
HOGENOMiHOG000077075.
InParanoidiQ46909.
OMAiTRNIRMI.
OrthoDBiEOG6SJJKM.
PhylomeDBiQ46909.

Enzyme and pathway databases

BioCyciEcoCyc:B2771-MONOMER.
ECOL316407:JW5845-MONOMER.

Miscellaneous databases

PROiQ46909.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.

Entry informationi

Entry nameiYGCS_ECOLI
AccessioniPrimary (citable) accession number: Q46909
Secondary accession number(s): Q2MA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 20, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.