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Protein

3-oxo-tetronate 4-phosphate decarboxylase

Gene

otnC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO2.By similarity

Catalytic activityi

3-oxo-tetronate 4-phosphate = dihydroxyacetone phosphate + CO2.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei79Proton acceptorBy similarity1
Metal bindingi79ZincBy similarity1
Metal bindingi98ZincBy similarity1
Metal bindingi100ZincBy similarity1
Active sitei125Proton donorBy similarity1
Metal bindingi165ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCarbohydrate metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G7419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxo-tetronate 4-phosphate decarboxylaseBy similarity (EC:4.1.1.-By similarity)
Gene namesi
Name:otnCBy similarity
Synonyms:ygbL
Ordered Locus Names:b2738, JW2708
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13106. ygbL.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001629301 – 2123-oxo-tetronate 4-phosphate decarboxylaseAdd BLAST212

Proteomic databases

PaxDbiQ46890.
PRIDEiQ46890.

Interactioni

Protein-protein interaction databases

BioGridi4261445. 11 interactors.
DIPiDIP-12113N.
IntActiQ46890. 2 interactors.
STRINGi316407.85675559.

Structurei

3D structure databases

ProteinModelPortaliQ46890.
SMRiQ46890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105FB2. Bacteria.
COG0235. LUCA.
HOGENOMiHOG000218185.
InParanoidiQ46890.
PhylomeDBiQ46890.

Family and domain databases

Gene3Di3.40.225.10. 1 hit.
InterProiView protein in InterPro
IPR001303. Aldolase_II/adducin_N.
PfamiView protein in Pfam
PF00596. Aldolase_II. 1 hit.
SMARTiView protein in SMART
SM01007. Aldolase_II. 1 hit.
SUPFAMiSSF53639. SSF53639. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46890-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFAKVEQS LREEMTRIAS SFFQRGYATG SAGNLSLLLP DGNLLATPTG
60 70 80 90 100
SCLGNLDPQR LSKVAADGEW LSGDKPSKEV LFHLALYRNN PRCKAVVHLH
110 120 130 140 150
STWSTALSCL QGLDSSNVIR PFTPYVVMRM GNVPLVPYYR PGDKRIAQDL
160 170 180 190 200
AELAADNQAF LLANHGPVVC GESLQEAANN MEELEETAKL IFILGDRPIR
210
YLTAGEIAEL RS
Length:212
Mass (Da):23,222
Last modified:November 1, 1996 - v1
Checksum:i13A2D480BD6BE02F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242208 Genomic DNA. Translation: AAG14969.1.
AF242210 Genomic DNA. Translation: AAG14982.1.
U29579 Genomic DNA. Translation: AAA69248.1.
U00096 Genomic DNA. Translation: AAC75780.1.
AP009048 Genomic DNA. Translation: BAE76815.1.
PIRiF65054.
RefSeqiNP_417218.1. NC_000913.3.
WP_001278994.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75780; AAC75780; b2738.
BAE76815; BAE76815; BAE76815.
GeneIDi947197.
KEGGiecj:JW2708.
eco:b2738.
PATRICifig|1411691.4.peg.4002.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOTNC_ECOLI
AccessioniPrimary (citable) accession number: Q46890
Secondary accession number(s): Q2MA91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families