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Protein

L-threonate dehydrogenase

Gene

ltnD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD+ or NADP+ as cosubstrate, with a preference for NAD+.By similarity

Catalytic activityi

L-threonate + NAD(P)+ = 2-oxo-tetronate + NAD(P)H.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102NADBy similarity1
Active sitei178By similarity1
Binding sitei246NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 35NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandNAD, NADP

Enzyme and pathway databases

BioCyciEcoCyc:G7417-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-threonate dehydrogenaseBy similarity (EC:1.1.1.-By similarity)
Gene namesi
Name:ltnDBy similarity
Synonyms:ygbJ
Ordered Locus Names:b2736, JW2706
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13104. ygbJ.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730621 – 302L-threonate dehydrogenaseAdd BLAST302

Proteomic databases

PaxDbiQ46888.
PRIDEiQ46888.

Interactioni

Protein-protein interaction databases

BioGridi4261443. 17 interactors.
IntActiQ46888. 3 interactors.
STRINGi316385.ECDH10B_2904.

Structurei

3D structure databases

ProteinModelPortaliQ46888.
SMRiQ46888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105ZXK. Bacteria.
COG2084. LUCA.
HOGENOMiHOG000219608.
InParanoidiQ46888.
KOiK08319.
PhylomeDBiQ46888.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiView protein in InterPro
IPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
PfamiView protein in Pfam
PF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00895. 3_HYDROXYISOBUT_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTGSEFHVG IVGLGSMGMG AALSYVRAGL STWGADLNSN ACATLKEAGA
60 70 80 90 100
CGVSDNAATF AEKLDALLVL VVNAAQVKQV LFGETGVAQH LKPGTAVMVS
110 120 130 140 150
STIASADAQE IATALAGFDL EMLDAPVSGG AVKAANGEMT VMASGSDIAF
160 170 180 190 200
ERLAPVLEAV AGKVYRIGAE PGLGSTVKII HQLLAGVHIA AGAEAMALAA
210 220 230 240 250
RAGIPLDVMY DVVTNAAGNS WMFENRMRHV VDGDYTPHSA VDIFVKDLGL
260 270 280 290 300
VADTAKALHF PLPLASTALN MFTSASNAGY GKEDDSAVIK IFSGITLPGA

KS
Length:302
Mass (Da):30,751
Last modified:November 1, 1996 - v1
Checksum:i09E94256EDDFC26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA. Translation: AAA69246.1.
U00096 Genomic DNA. Translation: AAC75778.1.
AP009048 Genomic DNA. Translation: BAE76813.1.
PIRiD65054.
RefSeqiNP_417216.1. NC_000913.3.
WP_000848004.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75778; AAC75778; b2736.
BAE76813; BAE76813; BAE76813.
GeneIDi947200.
KEGGiecj:JW2706.
eco:b2736.
PATRICifig|1411691.4.peg.4004.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLTND_ECOLI
AccessioniPrimary (citable) accession number: Q46888
Secondary accession number(s): Q2MA93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families