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Protein

L-threonate dehydrogenase

Gene

ltnD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD+ or NADP+ as cosubstrate, with a preference for NAD+.By similarity

Catalytic activityi

L-threonate + NAD+ = 2-dehydro-L-erythronate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102NADBy similarity1
Active sitei178By similarity1
Binding sitei246NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 35NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism
LigandNAD, NADP

Enzyme and pathway databases

BioCyciEcoCyc:G7417-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-threonate dehydrogenaseBy similarity (EC:1.1.1.411By similarity)
Gene namesi
Name:ltnDBy similarity
Synonyms:ygbJ
Ordered Locus Names:b2736, JW2706
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13104 ygbJ

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730621 – 302L-threonate dehydrogenaseAdd BLAST302

Proteomic databases

PaxDbiQ46888
PRIDEiQ46888

Interactioni

Protein-protein interaction databases

BioGridi4261443, 17 interactors
IntActiQ46888, 3 interactors
STRINGi316385.ECDH10B_2904

Structurei

3D structure databases

ProteinModelPortaliQ46888
SMRiQ46888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105ZXK Bacteria
COG2084 LUCA
HOGENOMiHOG000219608
InParanoidiQ46888
KOiK08319
OMAiQMFMQAS
PhylomeDBiQ46888

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Q46888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTGSEFHVG IVGLGSMGMG AALSYVRAGL STWGADLNSN ACATLKEAGA
60 70 80 90 100
CGVSDNAATF AEKLDALLVL VVNAAQVKQV LFGETGVAQH LKPGTAVMVS
110 120 130 140 150
STIASADAQE IATALAGFDL EMLDAPVSGG AVKAANGEMT VMASGSDIAF
160 170 180 190 200
ERLAPVLEAV AGKVYRIGAE PGLGSTVKII HQLLAGVHIA AGAEAMALAA
210 220 230 240 250
RAGIPLDVMY DVVTNAAGNS WMFENRMRHV VDGDYTPHSA VDIFVKDLGL
260 270 280 290 300
VADTAKALHF PLPLASTALN MFTSASNAGY GKEDDSAVIK IFSGITLPGA

KS
Length:302
Mass (Da):30,751
Last modified:November 1, 1996 - v1
Checksum:i09E94256EDDFC26C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29579 Genomic DNA Translation: AAA69246.1
U00096 Genomic DNA Translation: AAC75778.1
AP009048 Genomic DNA Translation: BAE76813.1
PIRiD65054
RefSeqiNP_417216.1, NC_000913.3
WP_000848004.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75778; AAC75778; b2736
BAE76813; BAE76813; BAE76813
GeneIDi947200
KEGGiecj:JW2706
eco:b2736
PATRICifig|1411691.4.peg.4004

Similar proteinsi

Entry informationi

Entry nameiLTND_ECOLI
AccessioniPrimary (citable) accession number: Q46888
Secondary accession number(s): Q2MA93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health