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Protein

Alcohol dehydrogenase YqhD

Gene

yqhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NADP-dependent ADH activity.1 Publication

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138NADP1 Publication1
Binding sitei147NADP1 Publication1
Binding sitei160NADP1 Publication1
Metal bindingi194Zinc; catalytic1
Metal bindingi198Zinc; catalytic1
Metal bindingi267Zinc; catalytic1
Metal bindingi281Zinc; catalytic1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 40NADP1 Publication3
Nucleotide bindingi93 – 99NADP1 Publication7
Nucleotide bindingi179 – 182NADP1 Publication4

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: EcoCyc
  • alcohol dehydrogenase [NAD(P)+] activity Source: EcoliWiki
  • aldehyde dehydrogenase (NADP+) activity Source: EcoCyc
  • methylglyoxal reductase (NADPH-dependent, acetol producing) Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • response to reactive oxygen species Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G7564-MONOMER.
ECOL316407:JW2978-MONOMER.
MetaCyc:G7564-MONOMER.
SABIO-RKQ46856.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase YqhD (EC:1.1.1.-)
Gene namesi
Name:yqhD
Ordered Locus Names:b3011, JW2978
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13014. yqhD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878321 – 387Alcohol dehydrogenase YqhDAdd BLAST387

Proteomic databases

PaxDbiQ46856.
PRIDEiQ46856.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4262380. 12 interactors.
DIPiDIP-12870N.
IntActiQ46856. 3 interactors.
STRINGi511145.b3011.

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Helixi18 – 21Combined sources4
Helixi23 – 25Combined sources3
Beta strandi31 – 35Combined sources5
Beta strandi37 – 39Combined sources3
Helixi40 – 44Combined sources5
Helixi46 – 53Combined sources8
Turni54 – 56Combined sources3
Beta strandi57 – 62Combined sources6
Helixi71 – 84Combined sources14
Beta strandi88 – 94Combined sources7
Helixi95 – 108Combined sources14
Helixi118 – 121Combined sources4
Turni122 – 126Combined sources5
Beta strandi133 – 139Combined sources7
Helixi144 – 146Combined sources3
Beta strandi150 – 153Combined sources4
Turni155 – 158Combined sources4
Beta strandi161 – 163Combined sources3
Turni166 – 168Combined sources3
Beta strandi171 – 175Combined sources5
Helixi177 – 180Combined sources4
Helixi185 – 200Combined sources16
Turni201 – 203Combined sources3
Beta strandi204 – 206Combined sources3
Helixi211 – 233Combined sources23
Helixi238 – 251Combined sources14
Beta strandi252 – 254Combined sources3
Turni255 – 259Combined sources5
Helixi265 – 277Combined sources13
Helixi281 – 295Combined sources15
Turni296 – 300Combined sources5
Helixi301 – 312Combined sources12
Helixi319 – 336Combined sources18
Helixi343 – 346Combined sources4
Helixi353 – 362Combined sources10
Beta strandi366 – 368Combined sources3
Turni369 – 372Combined sources4
Helixi376 – 385Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJ7X-ray2.00A/B/C/D2-387[»]
4QGSX-ray1.70A1-387[»]
ProteinModelPortaliQ46856.
SMRiQ46856.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46856.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108I6A. Bacteria.
COG1979. LUCA.
HOGENOMiHOG000243334.
InParanoidiQ46856.
KOiK08325.
OMAiSYETLMN.
PhylomeDBiQ46856.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFNLHTPT RILFGKGAIA GLREQIPHDA RVLITYGGGS VKKTGVLDQV
60 70 80 90 100
LDALKGMDVL EFGGIEPNPA YETLMNAVKL VREQKVTFLL AVGGGSVLDG
110 120 130 140 150
TKFIAAAANY PENIDPWHIL QTGGKEIKSA IPMGCVLTLP ATGSESNAGA
160 170 180 190 200
VISRKTTGDK QAFHSAHVQP VFAVLDPVYT YTLPPRQVAN GVVDAFVHTV
210 220 230 240 250
EQYVTKPVDA KIQDRFAEGI LLTLIEDGPK ALKEPENYDV RANVMWAATQ
260 270 280 290 300
ALNGLIGAGV PQDWATHMLG HELTAMHGLD HAQTLAIVLP ALWNEKRDTK
310 320 330 340 350
RAKLLQYAER VWNITEGSDD ERIDAAIAAT RNFFEQLGVP THLSDYGLDG
360 370 380
SSIPALLKKL EEHGMTQLGE NHDITLDVSR RIYEAAR
Length:387
Mass (Da):42,097
Last modified:November 1, 1996 - v1
Checksum:i448A7610787D2146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69178.1.
U00096 Genomic DNA. Translation: AAC76047.1.
AP009048 Genomic DNA. Translation: BAE77068.1.
PIRiA65088.
RefSeqiNP_417484.1. NC_000913.3.
WP_001058802.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76047; AAC76047; b3011.
BAE77068; BAE77068; BAE77068.
GeneIDi947493.
KEGGiecj:JW2978.
eco:b3011.
PATRICi32121438. VBIEscCol129921_3106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69178.1.
U00096 Genomic DNA. Translation: AAC76047.1.
AP009048 Genomic DNA. Translation: BAE77068.1.
PIRiA65088.
RefSeqiNP_417484.1. NC_000913.3.
WP_001058802.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJ7X-ray2.00A/B/C/D2-387[»]
4QGSX-ray1.70A1-387[»]
ProteinModelPortaliQ46856.
SMRiQ46856.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262380. 12 interactors.
DIPiDIP-12870N.
IntActiQ46856. 3 interactors.
STRINGi511145.b3011.

Proteomic databases

PaxDbiQ46856.
PRIDEiQ46856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76047; AAC76047; b3011.
BAE77068; BAE77068; BAE77068.
GeneIDi947493.
KEGGiecj:JW2978.
eco:b3011.
PATRICi32121438. VBIEscCol129921_3106.

Organism-specific databases

EchoBASEiEB2834.
EcoGeneiEG13014. yqhD.

Phylogenomic databases

eggNOGiENOG4108I6A. Bacteria.
COG1979. LUCA.
HOGENOMiHOG000243334.
InParanoidiQ46856.
KOiK08325.
OMAiSYETLMN.
PhylomeDBiQ46856.

Enzyme and pathway databases

BioCyciEcoCyc:G7564-MONOMER.
ECOL316407:JW2978-MONOMER.
MetaCyc:G7564-MONOMER.
SABIO-RKQ46856.

Miscellaneous databases

EvolutionaryTraceiQ46856.
PROiQ46856.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYQHD_ECOLI
AccessioniPrimary (citable) accession number: Q46856
Secondary accession number(s): Q2M9I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.