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Protein

Alcohol dehydrogenase YqhD

Gene

yqhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NADP-dependent ADH activity.1 Publication

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138NADP1 Publication1
Binding sitei147NADP1 Publication1
Binding sitei160NADP1 Publication1
Metal bindingi194Zinc; catalytic1
Metal bindingi198Zinc; catalytic1
Metal bindingi267Zinc; catalytic1
Metal bindingi281Zinc; catalytic1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 40NADP1 Publication3
Nucleotide bindingi93 – 99NADP1 Publication7
Nucleotide bindingi179 – 182NADP1 Publication4

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: EcoCyc
  • alcohol dehydrogenase [NAD(P)+] activity Source: EcoliWiki
  • methylglyoxal reductase (NADPH-dependent, acetol producing) Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • response to reactive oxygen species Source: EcoCyc

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G7564-MONOMER
MetaCyc:G7564-MONOMER
SABIO-RKiQ46856

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase YqhD (EC:1.1.1.-)
Gene namesi
Name:yqhD
Ordered Locus Names:b3011, JW2978
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13014 yqhD

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878321 – 387Alcohol dehydrogenase YqhDAdd BLAST387

Proteomic databases

PaxDbiQ46856
PRIDEiQ46856

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4262380, 40 interactors
DIPiDIP-12870N
IntActiQ46856, 3 interactors
STRINGi316385.ECDH10B_3186

Structurei

Secondary structure

1387
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi11 – 15Combined sources5
Helixi18 – 21Combined sources4
Helixi23 – 25Combined sources3
Beta strandi31 – 35Combined sources5
Beta strandi37 – 39Combined sources3
Helixi40 – 44Combined sources5
Helixi46 – 53Combined sources8
Turni54 – 56Combined sources3
Beta strandi57 – 62Combined sources6
Helixi71 – 84Combined sources14
Beta strandi88 – 94Combined sources7
Helixi95 – 108Combined sources14
Helixi118 – 121Combined sources4
Turni122 – 126Combined sources5
Beta strandi133 – 139Combined sources7
Helixi144 – 146Combined sources3
Beta strandi150 – 153Combined sources4
Turni155 – 158Combined sources4
Beta strandi161 – 163Combined sources3
Turni166 – 168Combined sources3
Beta strandi171 – 175Combined sources5
Helixi177 – 180Combined sources4
Helixi185 – 200Combined sources16
Turni201 – 203Combined sources3
Beta strandi204 – 206Combined sources3
Helixi211 – 233Combined sources23
Helixi238 – 251Combined sources14
Beta strandi252 – 254Combined sources3
Turni255 – 259Combined sources5
Helixi265 – 277Combined sources13
Helixi281 – 295Combined sources15
Turni296 – 300Combined sources5
Helixi301 – 312Combined sources12
Helixi319 – 336Combined sources18
Helixi343 – 346Combined sources4
Helixi353 – 362Combined sources10
Beta strandi366 – 368Combined sources3
Turni369 – 372Combined sources4
Helixi376 – 385Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OJ7X-ray2.00A/B/C/D2-387[»]
4QGSX-ray1.70A1-387[»]
ProteinModelPortaliQ46856
SMRiQ46856
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46856

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108I6A Bacteria
COG1979 LUCA
HOGENOMiHOG000243334
InParanoidiQ46856
KOiK08325
OMAiCTMALNG
PhylomeDBiQ46856

Family and domain databases

InterProiView protein in InterPro
IPR001670 ADH_Fe/gldA
IPR018211 ADH_Fe_CS
PfamiView protein in Pfam
PF00465 Fe-ADH, 1 hit
PROSITEiView protein in PROSITE
PS00913 ADH_IRON_1, 1 hit
PS00060 ADH_IRON_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFNLHTPT RILFGKGAIA GLREQIPHDA RVLITYGGGS VKKTGVLDQV
60 70 80 90 100
LDALKGMDVL EFGGIEPNPA YETLMNAVKL VREQKVTFLL AVGGGSVLDG
110 120 130 140 150
TKFIAAAANY PENIDPWHIL QTGGKEIKSA IPMGCVLTLP ATGSESNAGA
160 170 180 190 200
VISRKTTGDK QAFHSAHVQP VFAVLDPVYT YTLPPRQVAN GVVDAFVHTV
210 220 230 240 250
EQYVTKPVDA KIQDRFAEGI LLTLIEDGPK ALKEPENYDV RANVMWAATQ
260 270 280 290 300
ALNGLIGAGV PQDWATHMLG HELTAMHGLD HAQTLAIVLP ALWNEKRDTK
310 320 330 340 350
RAKLLQYAER VWNITEGSDD ERIDAAIAAT RNFFEQLGVP THLSDYGLDG
360 370 380
SSIPALLKKL EEHGMTQLGE NHDITLDVSR RIYEAAR
Length:387
Mass (Da):42,097
Last modified:November 1, 1996 - v1
Checksum:i448A7610787D2146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69178.1
U00096 Genomic DNA Translation: AAC76047.1
AP009048 Genomic DNA Translation: BAE77068.1
PIRiA65088
RefSeqiNP_417484.1, NC_000913.3
WP_001058802.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76047; AAC76047; b3011
BAE77068; BAE77068; BAE77068
GeneIDi947493
KEGGiecj:JW2978
eco:b3011
PATRICifig|1411691.4.peg.3718

Similar proteinsi

Entry informationi

Entry nameiYQHD_ECOLI
AccessioniPrimary (citable) accession number: Q46856
Secondary accession number(s): Q2M9I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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