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Protein

Alcohol dehydrogenase YqhD

Gene

yqhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

NADP-dependent ADH activity.1 Publication

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381NADP1 Publication
Binding sitei147 – 1471NADP1 Publication
Binding sitei160 – 1601NADP1 Publication
Metal bindingi194 – 1941Zinc; catalytic
Metal bindingi198 – 1981Zinc; catalytic
Metal bindingi267 – 2671Zinc; catalytic
Metal bindingi281 – 2811Zinc; catalytic

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 403NADP1 Publication
Nucleotide bindingi93 – 997NADP1 Publication
Nucleotide bindingi179 – 1824NADP1 Publication

GO - Molecular functioni

  • alcohol dehydrogenase (NADP+) activity Source: EcoCyc
  • alcohol dehydrogenase [NAD(P)+] activity Source: EcoliWiki
  • aldehyde dehydrogenase (NADP+) activity Source: EcoCyc
  • methylglyoxal reductase (NADPH-dependent, acetol producing) Source: EcoCyc
  • zinc ion binding Source: EcoCyc

GO - Biological processi

  • response to reactive oxygen species Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NADP, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G7564-MONOMER.
ECOL316407:JW2978-MONOMER.
MetaCyc:G7564-MONOMER.
SABIO-RKQ46856.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase YqhD (EC:1.1.1.-)
Gene namesi
Name:yqhD
Ordered Locus Names:b3011, JW2978
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13014. yqhD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Alcohol dehydrogenase YqhDPRO_0000087832Add
BLAST

Proteomic databases

PaxDbiQ46856.
PRIDEiQ46856.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4262380. 12 interactions.
DIPiDIP-12870N.
IntActiQ46856. 3 interactions.
STRINGi511145.b3011.

Structurei

Secondary structure

1
387
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 155Combined sources
Helixi18 – 214Combined sources
Helixi23 – 253Combined sources
Beta strandi31 – 355Combined sources
Beta strandi37 – 393Combined sources
Helixi40 – 445Combined sources
Helixi46 – 538Combined sources
Turni54 – 563Combined sources
Beta strandi57 – 626Combined sources
Helixi71 – 8414Combined sources
Beta strandi88 – 947Combined sources
Helixi95 – 10814Combined sources
Helixi118 – 1214Combined sources
Turni122 – 1265Combined sources
Beta strandi133 – 1397Combined sources
Helixi144 – 1463Combined sources
Beta strandi150 – 1534Combined sources
Turni155 – 1584Combined sources
Beta strandi161 – 1633Combined sources
Turni166 – 1683Combined sources
Beta strandi171 – 1755Combined sources
Helixi177 – 1804Combined sources
Helixi185 – 20016Combined sources
Turni201 – 2033Combined sources
Beta strandi204 – 2063Combined sources
Helixi211 – 23323Combined sources
Helixi238 – 25114Combined sources
Beta strandi252 – 2543Combined sources
Turni255 – 2595Combined sources
Helixi265 – 27713Combined sources
Helixi281 – 29515Combined sources
Turni296 – 3005Combined sources
Helixi301 – 31212Combined sources
Helixi319 – 33618Combined sources
Helixi343 – 3464Combined sources
Helixi353 – 36210Combined sources
Beta strandi366 – 3683Combined sources
Turni369 – 3724Combined sources
Helixi376 – 38510Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OJ7X-ray2.00A/B/C/D2-387[»]
4QGSX-ray1.70A1-387[»]
ProteinModelPortaliQ46856.
SMRiQ46856. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46856.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108I6A. Bacteria.
COG1979. LUCA.
HOGENOMiHOG000243334.
InParanoidiQ46856.
KOiK08325.
OMAiSYETLMN.
PhylomeDBiQ46856.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46856-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFNLHTPT RILFGKGAIA GLREQIPHDA RVLITYGGGS VKKTGVLDQV
60 70 80 90 100
LDALKGMDVL EFGGIEPNPA YETLMNAVKL VREQKVTFLL AVGGGSVLDG
110 120 130 140 150
TKFIAAAANY PENIDPWHIL QTGGKEIKSA IPMGCVLTLP ATGSESNAGA
160 170 180 190 200
VISRKTTGDK QAFHSAHVQP VFAVLDPVYT YTLPPRQVAN GVVDAFVHTV
210 220 230 240 250
EQYVTKPVDA KIQDRFAEGI LLTLIEDGPK ALKEPENYDV RANVMWAATQ
260 270 280 290 300
ALNGLIGAGV PQDWATHMLG HELTAMHGLD HAQTLAIVLP ALWNEKRDTK
310 320 330 340 350
RAKLLQYAER VWNITEGSDD ERIDAAIAAT RNFFEQLGVP THLSDYGLDG
360 370 380
SSIPALLKKL EEHGMTQLGE NHDITLDVSR RIYEAAR
Length:387
Mass (Da):42,097
Last modified:November 1, 1996 - v1
Checksum:i448A7610787D2146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69178.1.
U00096 Genomic DNA. Translation: AAC76047.1.
AP009048 Genomic DNA. Translation: BAE77068.1.
PIRiA65088.
RefSeqiNP_417484.1. NC_000913.3.
WP_001058802.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76047; AAC76047; b3011.
BAE77068; BAE77068; BAE77068.
GeneIDi947493.
KEGGiecj:JW2978.
eco:b3011.
PATRICi32121438. VBIEscCol129921_3106.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69178.1.
U00096 Genomic DNA. Translation: AAC76047.1.
AP009048 Genomic DNA. Translation: BAE77068.1.
PIRiA65088.
RefSeqiNP_417484.1. NC_000913.3.
WP_001058802.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OJ7X-ray2.00A/B/C/D2-387[»]
4QGSX-ray1.70A1-387[»]
ProteinModelPortaliQ46856.
SMRiQ46856. Positions 1-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262380. 12 interactions.
DIPiDIP-12870N.
IntActiQ46856. 3 interactions.
STRINGi511145.b3011.

Proteomic databases

PaxDbiQ46856.
PRIDEiQ46856.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76047; AAC76047; b3011.
BAE77068; BAE77068; BAE77068.
GeneIDi947493.
KEGGiecj:JW2978.
eco:b3011.
PATRICi32121438. VBIEscCol129921_3106.

Organism-specific databases

EchoBASEiEB2834.
EcoGeneiEG13014. yqhD.

Phylogenomic databases

eggNOGiENOG4108I6A. Bacteria.
COG1979. LUCA.
HOGENOMiHOG000243334.
InParanoidiQ46856.
KOiK08325.
OMAiSYETLMN.
PhylomeDBiQ46856.

Enzyme and pathway databases

BioCyciEcoCyc:G7564-MONOMER.
ECOL316407:JW2978-MONOMER.
MetaCyc:G7564-MONOMER.
SABIO-RKQ46856.

Miscellaneous databases

EvolutionaryTraceiQ46856.
PROiQ46856.

Family and domain databases

InterProiIPR001670. ADH_Fe.
IPR018211. ADH_Fe_CS.
[Graphical view]
PfamiPF00465. Fe-ADH. 1 hit.
[Graphical view]
PROSITEiPS00913. ADH_IRON_1. 1 hit.
PS00060. ADH_IRON_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYQHD_ECOLI
AccessioniPrimary (citable) accession number: Q46856
Secondary accession number(s): Q2M9I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.