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Protein

Glycolate permease GlcA

Gene

glcA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force.

Enzyme regulationi

Inhibited by carbonyl cyanide m-chlorophenylhydrazone (CCCP).

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:B2975-MONOMER.
ECOL316407:JW2942-MONOMER.
MetaCyc:B2975-MONOMER.

Protein family/group databases

TCDBi2.A.14.1.2. the lactate permease (lctp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycolate permease GlcA
Gene namesi
Name:glcA
Synonyms:yghK
Ordered Locus Names:b2975, JW2942
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12995. glcA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 417PeriplasmicSequence analysis
Transmembranei42 – 6221HelicalSequence analysisAdd
BLAST
Topological domaini63 – 697CytoplasmicSequence analysis
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 13040PeriplasmicSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1587CytoplasmicSequence analysis
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Topological domaini180 – 19920PeriplasmicSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Topological domaini221 – 2255CytoplasmicSequence analysis
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST
Topological domaini247 – 2482PeriplasmicSequence analysis
Transmembranei249 – 26921HelicalSequence analysisAdd
BLAST
Topological domaini270 – 31344CytoplasmicSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 37844PeriplasmicSequence analysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence analysisAdd
BLAST
Topological domaini400 – 40910CytoplasmicSequence analysis
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Topological domaini431 – 4399PeriplasmicSequence analysis
Transmembranei440 – 46021HelicalSequence analysisAdd
BLAST
Topological domaini461 – 53777CytoplasmicSequence analysisAdd
BLAST
Transmembranei538 – 55821HelicalSequence analysisAdd
BLAST
Topological domaini559 – 5602PeriplasmicSequence analysis

GO - Cellular componenti

  • integral component of plasma membrane Source: InterPro
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 560560Glycolate permease GlcAPRO_0000210380Add
BLAST

Proteomic databases

PaxDbiQ46839.
PRIDEiQ46839.

Expressioni

Inductioni

By glycolate.

Interactioni

Protein-protein interaction databases

DIPiDIP-12206N.
IntActiQ46839. 2 interactions.
STRINGi511145.b2975.

Structurei

3D structure databases

ProteinModelPortaliQ46839.
SMRiQ46839. Positions 412-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lactate permease family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DAA. Bacteria.
COG1620. LUCA.
HOGENOMiHOG000253321.
InParanoidiQ46839.
KOiK02550.
OMAiIRLCAIS.
PhylomeDBiQ46839.

Family and domain databases

InterProiIPR003804. Lactate_perm.
[Graphical view]
PANTHERiPTHR30003. PTHR30003. 1 hit.
PfamiPF02652. Lactate_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00795. lctP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTWTQMYMP MGGLGLSALV ALIPIIFFFV ALAVLRLKGH VAGAITLILS
60 70 80 90 100
ILIAIFAFKM PIDMAFAAAG YGFIYGLWPI AWIIVAAVFL YKLTVASGQF
110 120 130 140 150
DIIRSSVISI TDDQRLQVLL IGFSFGALLE GAAGFGAPVA ITGALLVGLG
160 170 180 190 200
FKPLYAAGLC LIANTAPVAF GALGVPILVA GQVTGIDPFH IGAMAGRQLP
210 220 230 240 250
FLSVLVPFWL VAMMDGWKGV KETWPAALVA GGSFAVTQFF TSNYIGPELP
260 270 280 290 300
DITSALVSIV SLALFLKVWR PKNTETAISM GQSAGAMVVN KPSSGGPVPS
310 320 330 340 350
EYSLGQIIRA WSPFLILTVL VTIWTMKPFK ALFAPGGAFY SLVINFQIPH
360 370 380 390 400
LHQQVLKAAP IVAQPTPMDA VFKFDPLSAG GTAIFIAAII SIFILGVGIK
410 420 430 440 450
KGIGVFAETL ISLKWPILSI GMVLAFAFVT NYSGMSTTLA LVLAGTGVMF
460 470 480 490 500
PFFSPFLGWL GVFLTGSDTS SNALFGSLQS TTAQQINVSD TLLVAANTSG
510 520 530 540 550
GVTGKMISPQ SIAVACAATG MVGRESELFR YTVKHSLIFA SVIGIITLLQ
560
AYVFTGMLVS
Length:560
Mass (Da):58,920
Last modified:November 1, 1996 - v1
Checksum:i8ECB9F9626FFC40A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69142.1.
U00096 Genomic DNA. Translation: AAC76011.1.
AP009048 Genomic DNA. Translation: BAE77035.1.
PIRiE65083.
RefSeqiNP_417449.1. NC_000913.3.
WP_000259302.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76011; AAC76011; b2975.
BAE77035; BAE77035; BAE77035.
GeneIDi947259.
KEGGiecj:JW2942.
eco:b2975.
PATRICi32121364. VBIEscCol129921_3069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69142.1.
U00096 Genomic DNA. Translation: AAC76011.1.
AP009048 Genomic DNA. Translation: BAE77035.1.
PIRiE65083.
RefSeqiNP_417449.1. NC_000913.3.
WP_000259302.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46839.
SMRiQ46839. Positions 412-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-12206N.
IntActiQ46839. 2 interactions.
STRINGi511145.b2975.

Protein family/group databases

TCDBi2.A.14.1.2. the lactate permease (lctp) family.

Proteomic databases

PaxDbiQ46839.
PRIDEiQ46839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76011; AAC76011; b2975.
BAE77035; BAE77035; BAE77035.
GeneIDi947259.
KEGGiecj:JW2942.
eco:b2975.
PATRICi32121364. VBIEscCol129921_3069.

Organism-specific databases

EchoBASEiEB2818.
EcoGeneiEG12995. glcA.

Phylogenomic databases

eggNOGiENOG4105DAA. Bacteria.
COG1620. LUCA.
HOGENOMiHOG000253321.
InParanoidiQ46839.
KOiK02550.
OMAiIRLCAIS.
PhylomeDBiQ46839.

Enzyme and pathway databases

BioCyciEcoCyc:B2975-MONOMER.
ECOL316407:JW2942-MONOMER.
MetaCyc:B2975-MONOMER.

Miscellaneous databases

PROiQ46839.

Family and domain databases

InterProiIPR003804. Lactate_perm.
[Graphical view]
PANTHERiPTHR30003. PTHR30003. 1 hit.
PfamiPF02652. Lactate_perm. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00795. lctP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLCA_ECOLI
AccessioniPrimary (citable) accession number: Q46839
Secondary accession number(s): Q2M9M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.