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Protein

Leader peptidase PppA

Gene

pppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: InterPro
  • endopeptidase activity Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7539-MONOMER

Protein family/group databases

MEROPSiA24.A01
TCDBi1.A.54.5.4 the presenilin er ca(2+) leak channel (presenilin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Leader peptidase PppA
Gene namesi
Name:pppA
Synonyms:yghH
Ordered Locus Names:b2972, JW2939
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12992 pppA

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14PeriplasmicSequence analysisAdd BLAST14
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 101CytoplasmicSequence analysisAdd BLAST64
Transmembranei102 – 121HelicalSequence analysisAdd BLAST20
Topological domaini122 – 124PeriplasmicSequence analysis3
Transmembranei125 – 142HelicalSequence analysisAdd BLAST18
Topological domaini143 – 176CytoplasmicSequence analysisAdd BLAST34
Transmembranei177 – 199HelicalSequence analysisAdd BLAST23
Topological domaini200 – 218PeriplasmicSequence analysisAdd BLAST19
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23
Topological domaini242 – 247CytoplasmicSequence analysis6
Transmembranei248 – 267HelicalSequence analysisAdd BLAST20
Topological domaini268 – 269PeriplasmicSequence analysis2

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926341 – 269Leader peptidase PppAAdd BLAST269

Proteomic databases

PaxDbiQ46836
PRIDEiQ46836

Interactioni

Protein-protein interaction databases

BioGridi4261823, 163 interactors
STRINGi316385.ECDH10B_3141

Structurei

3D structure databases

ProteinModelPortaliQ46836
SMRiQ46836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EHH Bacteria
COG1989 LUCA
HOGENOMiHOG000248584
InParanoidiQ46836
KOiK02654
OMAiVFWLFKL
PhylomeDBiQ46836

Family and domain databases

InterProiView protein in InterPro
IPR010627 Pept_A24A_N
IPR014032 Peptidase_A24A_bac
IPR000045 Prepilin_IV_endopep_pep
PfamiView protein in Pfam
PF06750 DiS_P_DiS, 1 hit
PF01478 Peptidase_A24, 1 hit
PRINTSiPR00864 PREPILNPTASE

Sequencei

Sequence statusi: Complete.

Q46836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFDVFQQYP TAMPVLATVG GLIIGSFLNV VIWRYPIMLR QQMAEFHGEM
60 70 80 90 100
SSAQSKISLA LPRSHCPHCQ QTIRIRDNIP LFSWLMLKGR CRDCQAKISK
110 120 130 140 150
RYPLVELLTA LAFLLASLVW PESGWGLAVM ILSAWLIAAS VIDLDHQWLP
160 170 180 190 200
DVFTQGVLWT GLIAAWAQQS PLTLQDAVTG VLVGFITFYS LRWIAGIVLR
210 220 230 240 250
KEALGMGDVL LFAALGGWVG ALSLPNVALI ASCCGLIYAV ITKRGSTTLP
260
FGPCLSLGGI ATLYLQALF
Length:269
Mass (Da):29,466
Last modified:May 30, 2000 - v2
Checksum:iE793FD8B4C81F6A4
GO

Sequence cautioni

The sequence AAA69139 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA Translation: AAA69139.1 Different initiation.
U00096 Genomic DNA Translation: AAC76008.2
AP009048 Genomic DNA Translation: BAE77033.1
PIRiB65083
RefSeqiNP_417446.4, NC_000913.3
WP_001333829.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76008; AAC76008; b2972
BAE77033; BAE77033; BAE77033
GeneIDi947467
KEGGiecj:JW2939
eco:b2972
PATRICifig|1411691.4.peg.3759

Similar proteinsi

Entry informationi

Entry nameiPPPA_ECOLI
AccessioniPrimary (citable) accession number: Q46836
Secondary accession number(s): Q2M9M3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health