Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leader peptidase PppA

Gene

pppA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • aspartic-type endopeptidase activity Source: InterPro
  • endopeptidase activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7539-MONOMER.
ECOL316407:JW2939-MONOMER.

Protein family/group databases

MEROPSiA24.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Leader peptidase PppA
Gene namesi
Name:pppA
Synonyms:yghH
Ordered Locus Names:b2972, JW2939
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12992. pppA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 14PeriplasmicSequence analysisAdd BLAST14
Transmembranei15 – 37HelicalSequence analysisAdd BLAST23
Topological domaini38 – 101CytoplasmicSequence analysisAdd BLAST64
Transmembranei102 – 121HelicalSequence analysisAdd BLAST20
Topological domaini122 – 124PeriplasmicSequence analysis3
Transmembranei125 – 142HelicalSequence analysisAdd BLAST18
Topological domaini143 – 176CytoplasmicSequence analysisAdd BLAST34
Transmembranei177 – 199HelicalSequence analysisAdd BLAST23
Topological domaini200 – 218PeriplasmicSequence analysisAdd BLAST19
Transmembranei219 – 241HelicalSequence analysisAdd BLAST23
Topological domaini242 – 247CytoplasmicSequence analysis6
Transmembranei248 – 267HelicalSequence analysisAdd BLAST20
Topological domaini268 – 269PeriplasmicSequence analysis2

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001926341 – 269Leader peptidase PppAAdd BLAST269

Proteomic databases

PaxDbiQ46836.
PRIDEiQ46836.

Interactioni

Protein-protein interaction databases

BioGridi4261823. 162 interactors.
STRINGi511145.b2972.

Structurei

3D structure databases

ProteinModelPortaliQ46836.
SMRiQ46836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase A24 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105EHH. Bacteria.
COG1989. LUCA.
HOGENOMiHOG000248584.
InParanoidiQ46836.
KOiK02654.
OMAiRCAYCHE.
PhylomeDBiQ46836.

Family and domain databases

InterProiIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamiPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSiPR00864. PREPILNPTASE.

Sequencei

Sequence statusi: Complete.

Q46836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFDVFQQYP TAMPVLATVG GLIIGSFLNV VIWRYPIMLR QQMAEFHGEM
60 70 80 90 100
SSAQSKISLA LPRSHCPHCQ QTIRIRDNIP LFSWLMLKGR CRDCQAKISK
110 120 130 140 150
RYPLVELLTA LAFLLASLVW PESGWGLAVM ILSAWLIAAS VIDLDHQWLP
160 170 180 190 200
DVFTQGVLWT GLIAAWAQQS PLTLQDAVTG VLVGFITFYS LRWIAGIVLR
210 220 230 240 250
KEALGMGDVL LFAALGGWVG ALSLPNVALI ASCCGLIYAV ITKRGSTTLP
260
FGPCLSLGGI ATLYLQALF
Length:269
Mass (Da):29,466
Last modified:May 30, 2000 - v2
Checksum:iE793FD8B4C81F6A4
GO

Sequence cautioni

The sequence AAA69139 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69139.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76008.2.
AP009048 Genomic DNA. Translation: BAE77033.1.
PIRiB65083.
RefSeqiNP_417446.4. NC_000913.3.
WP_001333829.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76008; AAC76008; b2972.
BAE77033; BAE77033; BAE77033.
GeneIDi947467.
KEGGiecj:JW2939.
eco:b2972.
PATRICi32121360. VBIEscCol129921_3067.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28377 Genomic DNA. Translation: AAA69139.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76008.2.
AP009048 Genomic DNA. Translation: BAE77033.1.
PIRiB65083.
RefSeqiNP_417446.4. NC_000913.3.
WP_001333829.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46836.
SMRiQ46836.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261823. 162 interactors.
STRINGi511145.b2972.

Protein family/group databases

MEROPSiA24.A01.

Proteomic databases

PaxDbiQ46836.
PRIDEiQ46836.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76008; AAC76008; b2972.
BAE77033; BAE77033; BAE77033.
GeneIDi947467.
KEGGiecj:JW2939.
eco:b2972.
PATRICi32121360. VBIEscCol129921_3067.

Organism-specific databases

EchoBASEiEB2816.
EcoGeneiEG12992. pppA.

Phylogenomic databases

eggNOGiENOG4105EHH. Bacteria.
COG1989. LUCA.
HOGENOMiHOG000248584.
InParanoidiQ46836.
KOiK02654.
OMAiRCAYCHE.
PhylomeDBiQ46836.

Enzyme and pathway databases

BioCyciEcoCyc:G7539-MONOMER.
ECOL316407:JW2939-MONOMER.

Miscellaneous databases

PROiQ46836.

Family and domain databases

InterProiIPR010627. Pept_A24A_N.
IPR014032. Peptidase_A24A_bac.
IPR000045. Prepilin_IV_endopep_pep.
[Graphical view]
PfamiPF06750. DiS_P_DiS. 1 hit.
PF01478. Peptidase_A24. 1 hit.
[Graphical view]
PRINTSiPR00864. PREPILNPTASE.
ProtoNetiSearch...

Entry informationi

Entry nameiPPPA_ECOLI
AccessioniPrimary (citable) accession number: Q46836
Secondary accession number(s): Q2M9M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 30, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.