ID   YGHF_ECOLI              Reviewed;         331 AA.
AC   Q46834; A0A7H2C769; Q2M9M5;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 2.
DT   27-MAR-2024, entry version 140.
DE   RecName: Full=Putative type II secretion system C-type protein YghF;
DE   AltName: Full=Putative general secretion pathway C-type protein YghF;
GN   Name=yghF {ECO:0000303|PubMed:9278503}; Synonyms=ecfA;
GN   OrderedLocusNames=b2970 {ECO:0000312|EMBL:QNV50516.1}, JW5484;
OS   Escherichia coli (strain K12).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Involved in a type II secretion system (T2SS, formerly
CC       general secretion pathway, GSP) for the export of folded proteins
CC       across the outer membrane. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Single-pass
CC       membrane protein {ECO:0000255}.
CC   -!- MISCELLANEOUS: In many other E.coli strains this gene is part of a type
CC       II secretion system, but in MG1655 the locus is missing a number of
CC       genes. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the GSP C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA69137.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE77031.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U28377; AAA69137.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; QNV50516.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77031.1; ALT_INIT; Genomic_DNA.
DR   PIR; H65082; H65082.
DR   RefSeq; WP_000135077.1; NZ_LN832404.1.
DR   AlphaFoldDB; Q46834; -.
DR   SMR; Q46834; -.
DR   BioGRID; 4261896; 12.
DR   DIP; DIP-12204N; -.
DR   IntAct; Q46834; 1.
DR   KEGG; ecj:JW5484; -.
DR   EchoBASE; EB2814; -.
DR   eggNOG; COG3031; Bacteria.
DR   HOGENOM; CLU_068012_2_0_6; -.
DR   InParanoid; Q46834; -.
DR   OrthoDB; 1491375at2; -.
DR   BioCyc; EcoCyc:G7537-MONOMER; -.
DR   PRO; PR:Q46834; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015627; C:type II protein secretion system complex; IEA:InterPro.
DR   GO; GO:0015628; P:protein secretion by the type II secretion system; IEA:InterPro.
DR   Gene3D; 2.30.30.830; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR024961; T2SS_GspC_N.
DR   InterPro; IPR001639; T2SS_protein-GspC.
DR   NCBIfam; TIGR01713; typeII_sec_gspC; 1.
DR   Pfam; PF11356; T2SSC; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   PROSITE; PS01141; T2SP_C; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Protein transport;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..331
FT                   /note="Putative type II secretion system C-type protein
FT                   YghF"
FT                   /id="PRO_0000013096"
FT   TRANSMEM        44..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   331 AA;  37349 MW;  3E26353F4DD5785C CRC64;
     MARVVFRDAR IYLIQWLTKI RHTLNQRQSL NTDKEHLRKI ARGMFWLMLL IISAKMAHSL
     WRYISFSAEY TAVSQPVNKP SRVDAKTFDK NDVQLISQQN WFGKYQPVAA QVKQPEPVPV
     AETRLNVVLR GIAFGARPGA VIEEGGKQQV YLQGETLGSH NAVIEEINRD HVMLRYQGKI
     ERLSLAEEER STVAVTNKKA VSDEAKQAVA EPAVSVPVEI PAAVRQALAK DPQKIFNYIQ
     LTPVRKEGIV GYAAKPGADR SLFDASGFKE GDIAIALNQQ DFTDPRAMIA LMRQLPSMDS
     IQLTVLRKGA RHDISIALRY RLFCPPYWKK S
//