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Protein

Uncharacterized protein YgfT

Gene

ygfT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 4 [4Fe-4S] clusters. May potentially bind 2 additional iron-sulfur clusters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi12 – 121Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi15 – 151Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi18 – 181Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi22 – 221Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi56 – 561Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi59 – 591Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi64 – 641Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi68 – 681Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi87 – 871Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi90 – 901Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi93 – 931Iron-sulfur 4 (4Fe-4S)By similarity
Metal bindingi97 – 971Iron-sulfur 3 (4Fe-4S)By similarity
Metal bindingi112 – 1121Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi115 – 1151Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi125 – 1251Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi129 – 1291Iron-sulfur 1 (4Fe-4S)By similarity
Metal bindingi210 – 2101Iron-sulfurSequence analysis
Metal bindingi213 – 2131Iron-sulfurSequence analysis
Metal bindingi219 – 2191Iron-sulfurSequence analysis
Metal bindingi223 – 2231Iron-sulfurSequence analysis
Metal bindingi258 – 2581Iron-sulfurSequence analysis
Metal bindingi262 – 2621Iron-sulfurSequence analysis
Metal bindingi268 – 2681Iron-sulfurSequence analysis
Metal bindingi272 – 2721Iron-sulfurSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7506-MONOMER.
ECOL316407:JW5469-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein YgfT
Gene namesi
Name:ygfT
Ordered Locus Names:b2887, JW5469
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13070. ygfT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 639639Uncharacterized protein YgfTPRO_0000170802Add
BLAST

Proteomic databases

PaxDbiQ46820.
PRIDEiQ46820.

Interactioni

Protein-protein interaction databases

BioGridi4262335. 15 interactions.
DIPiDIP-12175N.
STRINGi511145.b2887.

Structurei

3D structure databases

ProteinModelPortaliQ46820.
SMRiQ46820. Positions 5-131, 174-628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 32304Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini47 – 78324Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 107304Fe-4S ferredoxin-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini110 – 139304Fe-4S ferredoxin-type 4PROSITE-ProRule annotationAdd
BLAST
Domaini201 – 235354Fe-4S ferredoxin-type 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105BZ8. Bacteria.
COG0493. LUCA.
COG1142. LUCA.
HOGENOMiHOG000031439.
InParanoidiQ46820.
OMAiHAKPVRI.
OrthoDBiEOG6XSZQF.
PhylomeDBiQ46820.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR028261. DPD_II.
IPR023753. FAD/NAD-binding_dom.
IPR006006. Glut_synth_ssu2.
[Graphical view]
PfamiPF13247. Fer4_11. 1 hit.
PF14691. Fer4_20. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01318. gltD_gamma_fam. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKFIAAEAA ECIGCHACEI ACAVAHNQEN WPLSHSDFRP RIHVVGKGQA
60 70 80 90 100
ANPVACHHCN NAPCVTACPV NALTFQSDSV QLDEQKCIGC KRCAIACPFG
110 120 130 140 150
VVEMVDTIAQ KCDLCNQRSS GTQACIEVCP TQALRLMDDK GLQQIKVARQ
160 170 180 190 200
RKTAAGKASS DAQPSRSAAL LPVNSRKGAD KISASERKTH FGEIYCGLDP
210 220 230 240 250
QQATYESDRC VYCAEKANCN WHCPLHNAIP DYIRLVQEGK IIEAAELCHQ
260 270 280 290 300
TSSLPEICGR VCPQDRLCEG ACTLKDHSGA VSIGNLERYI TDTALAMGWR
310 320 330 340 350
PDVSKVVPRS EKVAVIGAGP AGLGCADILA RAGVQVDVFD RHPEIGGMLT
360 370 380 390 400
FGIPPFKLDK TVLSQRREIF TAMGIDFHLN CEIGRDITFS DLTSEYDAVF
410 420 430 440 450
IGVGTYGMMR ADLPHEDAPG VIQALPFLTA HTRQLMGLPE SEEYPLTDVE
460 470 480 490 500
GKRVVVLGGG DTTMDCLRTS IRLNAASVTC AYRRDEVSMP GSRKEVVNAR
510 520 530 540 550
EEGVEFQFNV QPQYIACDED GRLTAVGLIR TAMGEPGPDG RRRPRPVAGS
560 570 580 590 600
EFELPADVLI MAFGFQAHAM PWLQGSGIKL DKWGLIQTGD VGYLPTQTHL
610 620 630
KKVFAGGDAV HGADLVVTAM AAGRQAARDM LTLFDTKAS
Length:639
Mass (Da):69,089
Last modified:December 15, 1998 - v2
Checksum:i3B2B96621835655C
GO

Sequence cautioni

The sequence AAA83068.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83068.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75925.2.
AP009048 Genomic DNA. Translation: BAE76952.1.
PIRiG65072.
RefSeqiNP_417363.2. NC_000913.3.
WP_001350545.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75925; AAC75925; b2887.
BAE76952; BAE76952; BAE76952.
GeneIDi949018.
KEGGiecj:JW5469.
eco:b2887.
PATRICi32121182. VBIEscCol129921_2979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83068.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75925.2.
AP009048 Genomic DNA. Translation: BAE76952.1.
PIRiG65072.
RefSeqiNP_417363.2. NC_000913.3.
WP_001350545.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46820.
SMRiQ46820. Positions 5-131, 174-628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262335. 15 interactions.
DIPiDIP-12175N.
STRINGi511145.b2887.

Proteomic databases

PaxDbiQ46820.
PRIDEiQ46820.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75925; AAC75925; b2887.
BAE76952; BAE76952; BAE76952.
GeneIDi949018.
KEGGiecj:JW5469.
eco:b2887.
PATRICi32121182. VBIEscCol129921_2979.

Organism-specific databases

EchoBASEiEB2881.
EcoGeneiEG13070. ygfT.

Phylogenomic databases

eggNOGiENOG4105BZ8. Bacteria.
COG0493. LUCA.
COG1142. LUCA.
HOGENOMiHOG000031439.
InParanoidiQ46820.
OMAiHAKPVRI.
OrthoDBiEOG6XSZQF.
PhylomeDBiQ46820.

Enzyme and pathway databases

BioCyciEcoCyc:G7506-MONOMER.
ECOL316407:JW5469-MONOMER.

Miscellaneous databases

PROiQ46820.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR028261. DPD_II.
IPR023753. FAD/NAD-binding_dom.
IPR006006. Glut_synth_ssu2.
[Graphical view]
PfamiPF13247. Fer4_11. 1 hit.
PF14691. Fer4_20. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01318. gltD_gamma_fam. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiYGFT_ECOLI
AccessioniPrimary (citable) accession number: Q46820
Secondary accession number(s): Q2M9V4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.