UniProtKB - Q46817 (GHXQ_ECOLI)
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Protein
Guanine/hypoxanthine permease GhxQ
Gene
ghxQ
Organism
Escherichia coli (strain K12)
Status
Functioni
High-affinity transporter for guanine and hypoxanthine.1 Publication
Kineticsi
- KM=1.8 µM for guanine1 Publication
- KM=23.2 µM for hypoxanthine1 Publication
- Vmax=3.4 nmol/min/mg enzyme with guanine as substrate1 Publication
- Vmax=13.8 nmol/min/mg enzyme with hypoxanthine as substrate1 Publication
GO - Molecular functioni
- guanine transmembrane transporter activity Source: EcoCyc
GO - Biological processi
- guanine import across plasma membrane Source: EcoCyc
- hypoxanthine transport Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:G7504-MONOMER. MetaCyc:G7504-MONOMER. |
Protein family/group databases
TCDBi | 2.A.40.7.7. the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family. |
Names & Taxonomyi
Protein namesi | Recommended name: Guanine/hypoxanthine permease GhxQ |
Gene namesi | Name:ghxQ Synonyms:ygfQ, ygfR Ordered Locus Names:b4464, JW5467 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Organism-specific databases
EcoGenei | EG13067. ghxQ. |
Subcellular locationi
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 55 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 56 – 65 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 66 – 84 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 85 – 86 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 87 – 103 | Discontinuously helicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 104 – 115 | PeriplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 116 – 135 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 136 – 147 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 148 – 168 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 169 – 186 | PeriplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 187 – 204 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 205 – 208 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 209 – 228 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 229 – 260 | PeriplasmicSequence analysisAdd BLAST | 32 | |
Transmembranei | 261 – 289 | HelicalSequence analysisAdd BLAST | 29 | |
Topological domaini | 290 – 302 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 303 – 318 | HelicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 319 – 320 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 321 – 336 | Discontinuously helicalSequence analysisAdd BLAST | 16 | |
Topological domaini | 337 – 340 | CytoplasmicSequence analysis | 4 | |
Transmembranei | 341 – 355 | HelicalSequence analysisAdd BLAST | 15 | |
Topological domaini | 356 – 366 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 367 – 386 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 387 – 391 | CytoplasmicSequence analysis | 5 | |
Intramembranei | 392 – 427 | Discontinuously helicalSequence analysisAdd BLAST | 36 | |
Topological domaini | 428 – 455 | CytoplasmicSequence analysisAdd BLAST | 28 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169358 | 1 – 455 | Guanine/hypoxanthine permease GhxQAdd BLAST | 455 |
Proteomic databases
PaxDbi | Q46817. |
PRIDEi | Q46817. |
Interactioni
Protein-protein interaction databases
BioGridi | 4259228. 165 interactors. |
STRINGi | 316385.ECDH10B_3059. |
Family & Domainsi
Sequence similaritiesi
Belongs to the xanthine/uracil permease family. AzgA purine transporter (TC 2.A.1.40) subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105C7N. Bacteria. COG2252. LUCA. |
HOGENOMi | HOG000244363. |
InParanoidi | Q46817. |
KOi | K06901. |
OMAi | LMGCLFT. |
PhylomeDBi | Q46817. |
Family and domain databases
InterProi | View protein in InterPro IPR006043. Xant/urac/vitC. |
Pfami | View protein in Pfam PF00860. Xan_ur_permease. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q46817-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGDILQTPD APKPQGALDN YFKITARGST VRQEVLAGLT TFLAMVYSVI
60 70 80 90 100
VVPGMLGKAG FPPAAVFVAT CLVAGFGSLL MGLWANLPMA IGCAISLTAF
110 120 130 140 150
TAFSLVLGQQ ISVPVALGAV FLMGVIFTAI SVTGVRTWIL RNLPMGIAHG
160 170 180 190 200
TGIGIGLFLL LIAANGVGMV IKNPIEGLPV ALGAFTSFPV MMSLLGLAVI
210 220 230 240 250
FGLEKCRVPG GILLVIIAIS IIGLIFDPAV KYHGLVAMPS LTGEDGKSLI
260 270 280 290 300
FSLDIMGALQ PTVLPSVLAL VMTAVFDATG TIRAVAGQAN LLDKDNQIIN
310 320 330 340 350
GGKALTSDSV SSIFSGLVGA APAAVYIESA AGTAAGGKTG LTATVVGALF
360 370 380 390 400
LLILFLSPLS FLIPGYATAP ALMYVGLLML SNVSKLDFND FIDAMAGLVC
410 420 430 440 450
AVFIVLTCNI VTGIMLGFVT LVVGRVFARE WQKLNIGTVI ITAALVAFYA
GGWAI
Sequence cautioni
The sequence AAA83065 differs from that shown. Reason: Frameshift at position 179. Produces two separate ORFs (ygfQ and ygfR).Curated
The sequence AAA83066 differs from that shown. Reason: Frameshift at position 179. Produces two separate ORFs (ygfQ and ygfR).Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28375 Genomic DNA. Translation: AAA83065.1. Frameshift. U28375 Genomic DNA. Translation: AAA83066.1. Frameshift. U00096 Genomic DNA. Translation: AAT48153.1. AP009048 Genomic DNA. Translation: BAE76950.1. |
PIRi | D65072. E65072. |
RefSeqi | WP_000012163.1. NZ_LN832404.1. YP_026186.1. NC_000913.3. |
Genome annotation databases
EnsemblBacteriai | AAT48153; AAT48153; b4464. BAE76950; BAE76950; BAE76950. |
GeneIDi | 2847748. |
KEGGi | ecj:JW5467. eco:b4464. |
PATRICi | fig|1411691.4.peg.3850. |
Similar proteinsi
Entry informationi
Entry namei | GHXQ_ECOLI | |
Accessioni | Q46817Primary (citable) accession number: Q46817 Secondary accession number(s): Q2M9V6, Q46818, Q6BF61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 23, 2004 | |
Last modified: | March 28, 2018 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |