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Protein

Probable hypoxanthine oxidase XdhD

Gene

xdhD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably has no xanthine dehydrogenase activity; however deletion results in increased adenine sensitivity, suggesting that this protein contributes to the conversion of adenine to guanine nucleotides during purine salvage.1 Publication

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterCuratedNote: Binds 2 [2Fe-2S] centers.Curated
  • Mo-molybdopterinBy similarityNote: Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi414MolybdenumSequence analysis1
Metal bindingi445Molybdenum; via carbonyl oxygenSequence analysis1
Metal bindingi727Molybdenum; via amide nitrogenSequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyciEcoCyc:G7500-MONOMER.
ECOL316407:JW2849-MONOMER.
MetaCyc:G7500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable hypoxanthine oxidase XdhD (EC:1.-.-.-)
Gene namesi
Name:xdhD
Synonyms:ygfN
Ordered Locus Names:b2881, JW2849
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13064. xdhD.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001660961 – 956Probable hypoxanthine oxidase XdhDAdd BLAST956

Proteomic databases

PaxDbiQ46814.
PRIDEiQ46814.

Interactioni

Protein-protein interaction databases

BioGridi4262328. 14 interactors.
DIPiDIP-28056N.
IntActiQ46814. 3 interactors.
STRINGi511145.b2881.

Structurei

3D structure databases

ProteinModelPortaliQ46814.
SMRiQ46814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xanthine dehydrogenase family.Curated

Phylogenomic databases

eggNOGiENOG4105C7W. Bacteria.
COG1529. LUCA.
COG2080. LUCA.
HOGENOMiHOG000244715.
InParanoidiQ46814.
KOiK12528.
OMAiNSFMQYK.
PhylomeDBiQ46814.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.30.365.10. 7 hits.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR017699. Mo-bd_YgfN/XdhD.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 2 hits.
TIGRFAMsiTIGR03313. Se_sel_red_Mo. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIHFTLNGA PQELTVNPGE NVQKLLFNMG MHSVRNSDDG FGFAGSDAII
60 70 80 90 100
FNGNIVNASL LIAAQLEKAD IRTAESLGKW NELSLVQQAM VDVGVVQSGY
110 120 130 140 150
NDPAAALIIT DLLDRIAAPT REEIDDALSG LFSRDAGWQQ YYQVIELAVA
160 170 180 190 200
RKNNPQATID IAPTFRDDLE VIGKHYPKTD AAKMVQAKPC YVEDRVTADA
210 220 230 240 250
CVIKMLRSPH AHALITHLDV SKAEALPGVV HVITHLNCPD IYYTPGGQSA
260 270 280 290 300
PEPSPLDRRM FGKKMRHVGD RVAAVVAESE EIALEALKLI DVEYEVLKPV
310 320 330 340 350
MSIDEAMAED APVVHDEPVV YVAGAPDTLE DDNSHAAQRG EHMIINFPIG
360 370 380 390 400
SRPRKNIAAS IHGHIGDMDK GFADADVIIE RTYNSTQAQQ CPTETHICFT
410 420 430 440 450
RMDGDRLVIH ASTQVPWHLR RQVARLVGMK QHKVHVIKER VGGGFGSKQD
460 470 480 490 500
ILLEEVCAWA TCVTGRPVLF RYTREEEFIA NTSRHVAKVT VKLGAKKDGR
510 520 530 540 550
LTAVKMDFRA NTGPYGNHSL TVPCNGPALS LPLYPCDNVD FQVTTYYSNI
560 570 580 590 600
CPNGAYQGYG APKGNFAITM ALAELAEQLQ IDQLEIIERN RVHEGQELKI
610 620 630 640 650
LGAIGEGKAP TSVPSAASCA LEEILRQGRE MIQWSSPKPQ NGDWHIGRGV
660 670 680 690 700
AIIMQKSGIP DIDQANCMIK LESDGTFIVH SGGADIGTGL DTVVTKLAAE
710 720 730 740 750
VLHCPPQDVH VISGDTDHAL FDKGAYASSG TCFSGNAARL AAENLREKIL
760 770 780 790 800
FHGAQMLGEP VADVQLATPG VVRGKKGEVS FGDIAHKGET GTGFGSLVGT
810 820 830 840 850
GSYITPDFAF PYGANFAEVA VNTRTGEIRL DKFYALLDCG TPVNPELALG
860 870 880 890 900
QIYGATLRAI GHSMSEEIIY DAEGHPLTRD LRSYGAPKIG DIPRDFRAVL
910 920 930 940 950
VPSDDKVGPF GAKSISEIGV NGAAPAIATA IHDACGIWLR EWHFTPEKIL

TALEKI
Length:956
Mass (Da):103,519
Last modified:November 1, 1996 - v1
Checksum:iF60EEFE06F0AC17D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83062.1.
U00096 Genomic DNA. Translation: AAC75919.1.
AP009048 Genomic DNA. Translation: BAE76947.1.
PIRiA65072.
RefSeqiNP_417357.1. NC_000913.3.
WP_000583615.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75919; AAC75919; b2881.
BAE76947; BAE76947; BAE76947.
GeneIDi949079.
KEGGiecj:JW2849.
eco:b2881.
PATRICi32121172. VBIEscCol129921_2974.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83062.1.
U00096 Genomic DNA. Translation: AAC75919.1.
AP009048 Genomic DNA. Translation: BAE76947.1.
PIRiA65072.
RefSeqiNP_417357.1. NC_000913.3.
WP_000583615.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46814.
SMRiQ46814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262328. 14 interactors.
DIPiDIP-28056N.
IntActiQ46814. 3 interactors.
STRINGi511145.b2881.

Proteomic databases

PaxDbiQ46814.
PRIDEiQ46814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75919; AAC75919; b2881.
BAE76947; BAE76947; BAE76947.
GeneIDi949079.
KEGGiecj:JW2849.
eco:b2881.
PATRICi32121172. VBIEscCol129921_2974.

Organism-specific databases

EchoBASEiEB2876.
EcoGeneiEG13064. xdhD.

Phylogenomic databases

eggNOGiENOG4105C7W. Bacteria.
COG1529. LUCA.
COG2080. LUCA.
HOGENOMiHOG000244715.
InParanoidiQ46814.
KOiK12528.
OMAiNSFMQYK.
PhylomeDBiQ46814.

Enzyme and pathway databases

BioCyciEcoCyc:G7500-MONOMER.
ECOL316407:JW2849-MONOMER.
MetaCyc:G7500-MONOMER.

Miscellaneous databases

PROiQ46814.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.30.365.10. 7 hits.
3.90.1170.50. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR017699. Mo-bd_YgfN/XdhD.
[Graphical view]
PfamiPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF56003. SSF56003. 2 hits.
TIGRFAMsiTIGR03313. Se_sel_red_Mo. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiXDHD_ECOLI
AccessioniPrimary (citable) accession number: Q46814
Secondary accession number(s): Q2M9V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.