Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative oxidoreductase YgfK

Gene

ygfK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be an iron-sulfur flavoprotein with NADPH:O2 oxidoreductase activity.1 Publication

Cofactori

[4Fe-4S] clusterPROSITE-ProRule annotationNote: Binds 1 [4Fe-4S] cluster.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi938Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi941Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi944Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1
Metal bindingi948Iron-sulfur (4Fe-4S)PROSITE-ProRule annotation1

GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  • iron ion binding Source: EcoCyc
  • oxidoreductase activity Source: EcoCyc

Keywordsi

Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7497-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oxidoreductase YgfKCurated
Alternative name(s):
Putative oxidoreductase Fe-S subunit1 Publication
Gene namesi
Name:ygfK
Ordered Locus Names:b2878, JW5923
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13061 ygfK

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Insertion mutant is unable to reduce selenate to selenium.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002013291 – 1032Putative oxidoreductase YgfKAdd BLAST1032

Proteomic databases

PaxDbiQ46811
PRIDEiQ46811

Interactioni

Protein-protein interaction databases

BioGridi4262325, 21 interactors
DIPiDIP-28091N
IntActiQ46811, 2 interactors
STRINGi316385.ECDH10B_3053

Structurei

3D structure databases

ProteinModelPortaliQ46811
SMRiQ46811
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini928 – 9584Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd BLAST31

Phylogenomic databases

eggNOGiENOG4105BZ8 Bacteria
COG0493 LUCA
HOGENOMiHOG000277437
KOiK12527
OMAiNECGNCE

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
IPR017701 Se_rdtase_YgfK
PfamiView protein in Pfam
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 2 hits
TIGRFAMsiTIGR03315 Se_ygfK, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46811-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDIMRPIPF EELLTRIFDE YQQQRSIFGI PEQQFYSPVK GKTVSVFGET
60 70 80 90 100
CATPVGPAAG PHTQLAQNIV TSWLTGGRFI ELKTVQILDR LELEKPCIDA
110 120 130 140 150
EDECFNTEWS TEFTLLKAWD EYLKAWFALH LLEAMFQPSD SGKSFIFNMS
160 170 180 190 200
VGYNLEGIKQ PPMQQFIDNM MDASDHPKFA QYRDTLNKLL QDDAFLARHG
210 220 230 240 250
LQEKRESLQA LPARIPTSMV HGVTLSTMHG CPPHEIEAIC RYMLEEKGLN
260 270 280 290 300
TFVKLNPTLL GYARVREILD VCGFGYIGLK EESFDHDLKL TQALEMLERL
310 320 330 340 350
MALAKEKSLG FGVKLTNTLG TINNKGALPG EEMYMSGRAL FPLSINVAAV
360 370 380 390 400
LSRAFDGKLP ISYSGGASQL TIRDIFDTGI RPITMATDLL KPGGYLRLSA
410 420 430 440 450
CMRELEGSDA WGLDHVDVER LNRLAADALT MEYTQKHWKP EERIEVAEDL
460 470 480 490 500
PLTDCYVAPC VTACAIKQDI PEYIRLLGEH RYADALELIY QRNALPAITG
510 520 530 540 550
HICDHQCQYN CTRLDYDSAL NIRELKKVAL EKGWDEYKQR WHKPAGSGSR
560 570 580 590 600
HPVAVIGAGP AGLAAGYFLA RAGHPVTLFE REANAGGVVK NIIPQFRIPA
610 620 630 640 650
ELIQHDIDFV AAHGVKFEYG CSPDLTIEQL KNQGFHYVLI ATGTDKNSGV
660 670 680 690 700
KLAGDNQNVW KSLPFLREYN KGTALKLGKH VVVVGAGNTA MDCARAALRV
710 720 730 740 750
PGVEKATIVY RRSLQEMPAW REEYEEALHD GVEFRFLNNP ERFDADGTLT
760 770 780 790 800
LRVMSLGEPD EKGRRRPVET NETVTLLVDS LITAIGEQQD TEALNAMGVP
810 820 830 840 850
LDKNGWPDVD HNGETRLTDV FMIGDVQRGP SSIVAAVGTA RRATDAILSR
860 870 880 890 900
ENIRSHQNDK YWNNVNPAEI YQRKGDISIT LVNSDDRDAF VAQEAARCLE
910 920 930 940 950
CNYVCSKCVD VCPNRANVSI AVPGFQNRFQ TLHLDAYCNE CGNCAQFCPW
960 970 980 990 1000
NGKPYKDKIT VFSLAQDFDN SSNPGFLVED CRVRVRLNNQ SWVLNIDSKG
1010 1020 1030
QFNNVPPELN DMCRIISHVH QHHHYLLGRV EV
Length:1,032
Mass (Da):115,582
Last modified:November 1, 1996 - v1
Checksum:i588056B51BE89648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83059.1
U00096 Genomic DNA Translation: AAC75916.1
AP009048 Genomic DNA Translation: BAE76944.1
PIRiF65071
RefSeqiNP_417354.1, NC_000913.3
WP_000502395.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75916; AAC75916; b2878
BAE76944; BAE76944; BAE76944
GeneIDi949068
KEGGiecj:JW5923
eco:b2878
PATRICifig|1411691.4.peg.3856

Similar proteinsi

Entry informationi

Entry nameiYGFK_ECOLI
AccessioniPrimary (citable) accession number: Q46811
Secondary accession number(s): Q2M9W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health