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Protein

Putative carbamoyltransferase YgeW

Gene

ygeW

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative carbamoyltransferase. No activity can be detected with allantoin or 25 other related compounds, including 20 naturally occurring amino acids, N-acetyl-L-ornithine, N-succinyl-L-ornithine, L-ornithine, oxamate, beta-alanine and putrescine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Carbamoyl phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciEcoCyc:G7489-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Putative carbamoyltransferase YgeWCurated (EC:2.1.3.-1 Publication)
Alternative name(s):
UTCase1 Publication
Gene namesi
Name:ygeW
Ordered Locus Names:b2870, JW5463
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13053 ygeW

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001132631 – 396Putative carbamoyltransferase YgeWAdd BLAST396

Proteomic databases

PaxDbiQ46803
PRIDEiQ46803

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi4261510, 19 interactors
STRINGi316385.ECDH10B_3045

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Helixi19 – 21Combined sources3
Helixi27 – 29Combined sources3
Helixi32 – 50Combined sources19
Beta strandi62 – 68Combined sources7
Helixi77 – 85Combined sources9
Beta strandi88 – 91Combined sources4
Helixi105 – 111Combined sources7
Beta strandi116 – 123Combined sources8
Helixi133 – 146Combined sources14
Beta strandi155 – 160Combined sources6
Helixi166 – 180Combined sources15
Beta strandi181 – 183Combined sources3
Helixi184 – 186Combined sources3
Beta strandi190 – 194Combined sources5
Helixi206 – 215Combined sources10
Helixi216 – 218Combined sources3
Beta strandi221 – 225Combined sources5
Helixi234 – 247Combined sources14
Beta strandi250 – 255Combined sources6
Helixi257 – 261Combined sources5
Beta strandi265 – 269Combined sources5
Helixi275 – 286Combined sources12
Helixi290 – 305Combined sources16
Turni306 – 309Combined sources4
Helixi314 – 318Combined sources5
Helixi321 – 323Combined sources3
Beta strandi339 – 342Combined sources4
Beta strandi344 – 346Combined sources3
Helixi347 – 362Combined sources16
Helixi364 – 376Combined sources13
Helixi380 – 390Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q98X-ray2.00A1-396[»]
ProteinModelPortaliQ46803
SMRiQ46803
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46803

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni71 – 74Carbamoyl phosphate bindingBy similarity4
Regioni165 – 168Carbamoyl phosphate bindingBy similarity4
Regioni330 – 331Carbamoyl phosphate bindingBy similarity2

Domaini

Contains a carbamoyl phosphate domain (CPD) and a second substrate domain (SSD), which are linked by two helices.1 Publication

Sequence similaritiesi

Belongs to the ATCase/OTCase family.Curated

Phylogenomic databases

eggNOGiENOG4105IW6 Bacteria
COG0078 LUCA
HOGENOMiHOG000022686
InParanoidiQ46803
OMAiIDHPTQA
PhylomeDBiQ46803

Family and domain databases

Gene3Di3.40.50.1370, 3 hits
InterProiView protein in InterPro
IPR006132 Asp/Orn_carbamoyltranf_P-bd
IPR006130 Asp/Orn_carbamoylTrfase
IPR036901 Asp/Orn_carbamoylTrfase_sf
IPR002082 Asp_carbamoyltransf
IPR006131 Asp_carbamoyltransf_Asp/Orn-bd
IPR017702 Carbamoyltransferase_YgeW
PANTHERiPTHR11405:SF40 PTHR11405:SF40, 1 hit
PfamiView protein in Pfam
PF00185 OTCace, 1 hit
PF02729 OTCace_N, 1 hit
PRINTSiPR00100 AOTCASE
PR00101 ATCASE
SUPFAMiSSF53671 SSF53671, 1 hit
TIGRFAMsiTIGR03316 ygeW, 1 hit

Sequencei

Sequence statusi: Complete.

Q46803-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKTVNELIK DINSLTSHLH EKDFLLTWEQ TPDELKQVLD VAAALKALRA
60 70 80 90 100
ENISTKVFNS GLGISVFRDN STRTRFSYAS ALNLLGLAQQ DLDEGKSQIA
110 120 130 140 150
HGETVRETAN MISFCADAIG IRDDMYLGAG NAYMREVGAA LDDGYKQGVL
160 170 180 190 200
PQRPALVNLQ CDIDHPTQSM ADLAWLREHF GSLENLKGKK IAMTWAYSPS
210 220 230 240 250
YGKPLSVPQG IIGLMTRFGM DVTLAHPEGY DLIPDVVEVA KNNAKASGGS
260 270 280 290 300
FRQVTSMEEA FKDADIVYPK SWAPYKVMEE RTELLRANDH EGLKALEKQC
310 320 330 340 350
LAQNAQHKDW HCTEEMMELT RDGEALYMHC LPADISGVSC KEGEVTEGVF
360 370 380 390
EKYRIATYKE ASWKPYIIAA MILSRKYAKP GALLEQLLKE AQERVK
Length:396
Mass (Da):44,187
Last modified:October 11, 2004 - v2
Checksum:i62C5A199BB31FD46
GO

Sequence cautioni

The sequence AAA83051 differs from that shown. Reason: Frameshift at positions 18 and 373.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83051.1 Frameshift.
U00096 Genomic DNA Translation: AAT48152.1
AP009048 Genomic DNA Translation: BAE76936.1
PIRiF65070
RefSeqiWP_000978544.1, NZ_LN832404.1
YP_026185.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48152; AAT48152; b2870
BAE76936; BAE76936; BAE76936
GeneIDi945826
KEGGiecj:JW5463
eco:b2870
PATRICifig|511145.12.peg.2963

Similar proteinsi

Entry informationi

Entry nameiYGEW_ECOLI
AccessioniPrimary (citable) accession number: Q46803
Secondary accession number(s): Q2M9X0, Q6BF62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health