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Protein

Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC

Gene

xdhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur subunit of the xanthine dehydrogenase complex.

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 2 [2Fe-2S] clusters.By similarity

Pathwayi: hypoxanthine degradation

This protein is involved in step 1 of the subpathway that synthesizes urate from hypoxanthine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC (xdhC), Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (xdhA), Putative xanthine dehydrogenase FAD-binding subunit XdhB (xdhB)
  2. Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (xdhA), Putative xanthine dehydrogenase FAD-binding subunit XdhB (xdhB)
This subpathway is part of the pathway hypoxanthine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes urate from hypoxanthine, the pathway hypoxanthine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi49Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi52Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPurine metabolism, Purine salvage
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7487-MONOMER.
MetaCyc:G7487-MONOMER.
UniPathwayiUPA00604; UER00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC
Gene namesi
Name:xdhC
Synonyms:ygeU
Ordered Locus Names:b2868, JW2836
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13051. xdhC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894121 – 159Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhCAdd BLAST159

Proteomic databases

PaxDbiQ46801.
PRIDEiQ46801.

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC.Curated

Protein-protein interaction databases

BioGridi4262321. 8 interactors.
IntActiQ46801. 4 interactors.
STRINGi316385.ECDH10B_3043.

Structurei

3D structure databases

ProteinModelPortaliQ46801.
SMRiQ46801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 822Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiENOG4108UTP. Bacteria.
COG2080. LUCA.
HOGENOMiHOG000166647.
InParanoidiQ46801.
KOiK13480.
PhylomeDBiQ46801.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
InterProiView protein in InterPro
IPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
PfamiView protein in Pfam
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
PROSITEiView protein in PROSITE
PS51085. 2FE2S_FER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q46801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSETITIE CTINGMPFQL HAAPGTPLSE LLREQGLLSV KQGCCVGECG
60 70 80 90 100
ACTVLVDGTA IDSCLYLAAW AEGKEIRTLE GEAKGGKLSH VQQAYAKSGA
110 120 130 140 150
VQCGFCTPGL IMATTAMLAK PREKPLTITE IRRGLAGNLC RCTGYQMIVN

TVLDCEKTK
Length:159
Mass (Da):16,922
Last modified:November 1, 1996 - v1
Checksum:iB29F77F0DC06798C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83049.1.
U00096 Genomic DNA. Translation: AAC75906.1.
AP009048 Genomic DNA. Translation: BAE76934.1.
PIRiD65070.
RefSeqiNP_417344.1. NC_000913.3.
WP_001016605.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75906; AAC75906; b2868.
BAE76934; BAE76934; BAE76934.
GeneIDi945148.
KEGGiecj:JW2836.
eco:b2868.
PATRICifig|1411691.4.peg.3866.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiXDHC_ECOLI
AccessioniPrimary (citable) accession number: Q46801
Secondary accession number(s): Q2M9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways