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Protein

Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC

Gene

xdhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur subunit of the xanthine dehydrogenase complex.

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 2 [2Fe-2S] clusters.By similarity

Pathwayi: hypoxanthine degradation

This protein is involved in step 1 of the subpathway that synthesizes urate from hypoxanthine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC (xdhC), Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (xdhA), Putative xanthine dehydrogenase FAD-binding subunit XdhB (xdhB)
  2. Putative xanthine dehydrogenase molybdenum-binding subunit XdhA (xdhA), Putative xanthine dehydrogenase FAD-binding subunit XdhB (xdhB)
This subpathway is part of the pathway hypoxanthine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes urate from hypoxanthine, the pathway hypoxanthine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi44Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi49Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi52Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPurine metabolism, Purine salvage
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7487-MONOMER
MetaCyc:G7487-MONOMER
UniPathwayiUPA00604; UER00661

Names & Taxonomyi

Protein namesi
Recommended name:
Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhC
Gene namesi
Name:xdhC
Synonyms:ygeU
Ordered Locus Names:b2868, JW2836
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi

Organism-specific databases

EcoGeneiEG13051 xdhC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001894121 – 159Putative xanthine dehydrogenase iron-sulfur-binding subunit XdhCAdd BLAST159

Proteomic databases

PaxDbiQ46801
PRIDEiQ46801

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC.Curated

Protein-protein interaction databases

BioGridi4262321, 8 interactors
IntActiQ46801, 4 interactors
STRINGi316385.ECDH10B_3043

Structurei

3D structure databases

ProteinModelPortaliQ46801
SMRiQ46801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 822Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiENOG4108UTP Bacteria
COG2080 LUCA
HOGENOMiHOG000166647
InParanoidiQ46801
KOiK13480
OMAiQEADDVW
PhylomeDBiQ46801

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR002888 2Fe-2S-bd
IPR036884 2Fe-2S-bd_dom_sf
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR012675 Beta-grasp_dom_sf
PfamiView protein in Pfam
PF00111 Fer2, 1 hit
PF01799 Fer2_2, 1 hit
SUPFAMiSSF47741 SSF47741, 1 hit
SSF54292 SSF54292, 1 hit
PROSITEiView protein in PROSITE
PS51085 2FE2S_FER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q46801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSETITIE CTINGMPFQL HAAPGTPLSE LLREQGLLSV KQGCCVGECG
60 70 80 90 100
ACTVLVDGTA IDSCLYLAAW AEGKEIRTLE GEAKGGKLSH VQQAYAKSGA
110 120 130 140 150
VQCGFCTPGL IMATTAMLAK PREKPLTITE IRRGLAGNLC RCTGYQMIVN

TVLDCEKTK
Length:159
Mass (Da):16,922
Last modified:November 1, 1996 - v1
Checksum:iB29F77F0DC06798C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA Translation: AAA83049.1
U00096 Genomic DNA Translation: AAC75906.1
AP009048 Genomic DNA Translation: BAE76934.1
PIRiD65070
RefSeqiNP_417344.1, NC_000913.3
WP_001016605.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75906; AAC75906; b2868
BAE76934; BAE76934; BAE76934
GeneIDi945148
KEGGiecj:JW2836
eco:b2868
PATRICifig|1411691.4.peg.3866

Similar proteinsi

Entry informationi

Entry nameiXDHC_ECOLI
AccessioniPrimary (citable) accession number: Q46801
Secondary accession number(s): Q2M9X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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