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Protein

Xanthine dehydrogenase iron-sulfur-binding subunit

Gene

xdhC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur subunit of the xanthine dehydrogenase complex.

Cofactori

[2Fe-2S] clusterBy similarityNote: Binds 2 [2Fe-2S] clusters.By similarity

Pathwayi: hypoxanthine degradation

This protein is involved in step 1 of the subpathway that synthesizes urate from hypoxanthine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Xanthine dehydrogenase iron-sulfur-binding subunit (xdhC), Xanthine dehydrogenase molybdenum-binding subunit (xdhA), Xanthine dehydrogenase FAD-binding subunit (xdhB)
  2. Xanthine dehydrogenase molybdenum-binding subunit (xdhA), Xanthine dehydrogenase FAD-binding subunit (xdhB)
This subpathway is part of the pathway hypoxanthine degradation, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes urate from hypoxanthine, the pathway hypoxanthine degradation and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi49 – 491Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation
Metal bindingi52 – 521Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7487-MONOMER.
ECOL316407:JW2836-MONOMER.
MetaCyc:G7487-MONOMER.
UniPathwayiUPA00604; UER00661.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase iron-sulfur-binding subunit
Gene namesi
Name:xdhC
Synonyms:ygeU
Ordered Locus Names:b2868, JW2836
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13051. xdhC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Xanthine dehydrogenase iron-sulfur-binding subunitPRO_0000189412Add
BLAST

Proteomic databases

PaxDbiQ46801.

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC.Curated

Protein-protein interaction databases

BioGridi4262321. 8 interactions.
IntActiQ46801. 4 interactions.
STRINGi511145.b2868.

Structurei

3D structure databases

ProteinModelPortaliQ46801.
SMRiQ46801. Positions 7-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 82762Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4108UTP. Bacteria.
COG2080. LUCA.
HOGENOMiHOG000166647.
InParanoidiQ46801.
KOiK13480.
OMAiAMRDCHG.
OrthoDBiEOG6ZSP3F.
PhylomeDBiQ46801.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46801-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHSETITIE CTINGMPFQL HAAPGTPLSE LLREQGLLSV KQGCCVGECG
60 70 80 90 100
ACTVLVDGTA IDSCLYLAAW AEGKEIRTLE GEAKGGKLSH VQQAYAKSGA
110 120 130 140 150
VQCGFCTPGL IMATTAMLAK PREKPLTITE IRRGLAGNLC RCTGYQMIVN

TVLDCEKTK
Length:159
Mass (Da):16,922
Last modified:November 1, 1996 - v1
Checksum:iB29F77F0DC06798C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83049.1.
U00096 Genomic DNA. Translation: AAC75906.1.
AP009048 Genomic DNA. Translation: BAE76934.1.
PIRiD65070.
RefSeqiNP_417344.1. NC_000913.3.
WP_001016605.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75906; AAC75906; b2868.
BAE76934; BAE76934; BAE76934.
GeneIDi945148.
KEGGiecj:JW2836.
eco:b2868.
PATRICi32121146. VBIEscCol129921_2961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83049.1.
U00096 Genomic DNA. Translation: AAC75906.1.
AP009048 Genomic DNA. Translation: BAE76934.1.
PIRiD65070.
RefSeqiNP_417344.1. NC_000913.3.
WP_001016605.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46801.
SMRiQ46801. Positions 7-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262321. 8 interactions.
IntActiQ46801. 4 interactions.
STRINGi511145.b2868.

Proteomic databases

PaxDbiQ46801.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75906; AAC75906; b2868.
BAE76934; BAE76934; BAE76934.
GeneIDi945148.
KEGGiecj:JW2836.
eco:b2868.
PATRICi32121146. VBIEscCol129921_2961.

Organism-specific databases

EchoBASEiEB2863.
EcoGeneiEG13051. xdhC.

Phylogenomic databases

eggNOGiENOG4108UTP. Bacteria.
COG2080. LUCA.
HOGENOMiHOG000166647.
InParanoidiQ46801.
KOiK13480.
OMAiAMRDCHG.
OrthoDBiEOG6ZSP3F.
PhylomeDBiQ46801.

Enzyme and pathway databases

UniPathwayiUPA00604; UER00661.
BioCyciEcoCyc:G7487-MONOMER.
ECOL316407:JW2836-MONOMER.
MetaCyc:G7487-MONOMER.

Miscellaneous databases

PROiQ46801.

Family and domain databases

Gene3Di1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
InterProiIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR012675. Beta-grasp_dom.
[Graphical view]
PfamiPF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
SUPFAMiSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage."
    Xi H., Schneider B.L., Reitzer L.
    J. Bacteriol. 182:5332-5341(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF FUNCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiXDHC_ECOLI
AccessioniPrimary (citable) accession number: Q46801
Secondary accession number(s): Q2M9X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: January 20, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.