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Q46800

- XDHB_ECOLI

UniProt

Q46800 - XDHB_ECOLI

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Protein
Xanthine dehydrogenase FAD-binding subunit
Gene
xdhB, ygeT, b2867, JW2835
Organism
Escherichia coli (strain K12)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism).1 Publication

Catalytic activityi

Xanthine + NAD+ + H2O = urate + NADH.
Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactori

FAD By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei165 – 1651FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei184 – 1841FAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi27 – 348FAD By similarity
Nucleotide bindingi109 – 1135FAD By similarity

GO - Molecular functioni

  1. FAD binding Source: EcoliWiki
  2. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
  3. xanthine dehydrogenase activity Source: EcoliWiki

GO - Biological processi

  1. hypoxanthine oxidation Source: EcoliWiki
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Purine metabolism, Purine salvage

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciEcoCyc:G7486-MONOMER.
ECOL316407:JW2835-MONOMER.
MetaCyc:G7486-MONOMER.
UniPathwayiUPA00604; UER00661.
UPA00604; UER00662.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine dehydrogenase FAD-binding subunit (EC:1.17.1.4)
Gene namesi
Name:xdhB
Synonyms:ygeT
Ordered Locus Names:b2867, JW2835
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
ProteomesiUP000000318: Chromosome, UP000000625: Chromosome

Organism-specific databases

EcoGeneiEG13050. xdhB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Xanthine dehydrogenase FAD-binding subunit
PRO_0000166092Add
BLAST

Proteomic databases

PaxDbiQ46800.
PRIDEiQ46800.

Expressioni

Gene expression databases

GenevestigatoriQ46800.

Interactioni

Subunit structurei

Heterotrimer of XdhA, XdhB and XdhC Inferred.

Protein-protein interaction databases

IntActiQ46800. 5 interactions.
STRINGi511145.b2867.

Structurei

3D structure databases

ProteinModelPortaliQ46800.
SMRiQ46800. Positions 3-285.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 176176FAD-binding PCMH-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1319.
HOGENOMiHOG000244729.
KOiK13479.
OMAiIVGNICR.
OrthoDBiEOG6ZSP3F.
PhylomeDBiQ46800.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProiIPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view]
PfamiPF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view]
SMARTiSM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46800-1 [UniParc]FASTAAdd to Basket

« Hide

MFDFASYHRA ATLADAINLL ADNPQAKLLA GGTDVLIQLH HHNDRYRHIV    50
DIHNLAELRG ITLAEDGSLR IGSATTFTQL IEDPITQRHL PALCAAATSI 100
AGPQIRNVAT YGGNICNGAT SADSATPTLI YDAKLEIHSP RGVRFVPING 150
FHTGPGKVSL EHDEILVAFH FPPQPKEHAG SAHFKYAMRD AMDISTIGCA 200
AHCRLDNGNF SELRLAFGVA APTPIRCQHA EQTAQNAPLN LQTLEAISES 250
VLQDVAPRSS WRASKEFRLH LIQTMTKKVI SEAVAAAGGK LQ 292
Length:292
Mass (Da):31,557
Last modified:November 1, 1996 - v1
Checksum:i74A07D137DA857E8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28375 Genomic DNA. Translation: AAA83048.1.
U00096 Genomic DNA. Translation: AAC75905.1.
AP009048 Genomic DNA. Translation: BAE76933.1.
PIRiC65070.
RefSeqiNP_417343.1. NC_000913.3.
YP_491069.1. NC_007779.1.

Genome annotation databases

EnsemblBacteriaiAAC75905; AAC75905; b2867.
BAE76933; BAE76933; BAE76933.
GeneIDi12933326.
947205.
KEGGiecj:Y75_p2800.
eco:b2867.
PATRICi32121144. VBIEscCol129921_2960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28375 Genomic DNA. Translation: AAA83048.1 .
U00096 Genomic DNA. Translation: AAC75905.1 .
AP009048 Genomic DNA. Translation: BAE76933.1 .
PIRi C65070.
RefSeqi NP_417343.1. NC_000913.3.
YP_491069.1. NC_007779.1.

3D structure databases

ProteinModelPortali Q46800.
SMRi Q46800. Positions 3-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q46800. 5 interactions.
STRINGi 511145.b2867.

Proteomic databases

PaxDbi Q46800.
PRIDEi Q46800.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC75905 ; AAC75905 ; b2867 .
BAE76933 ; BAE76933 ; BAE76933 .
GeneIDi 12933326.
947205.
KEGGi ecj:Y75_p2800.
eco:b2867.
PATRICi 32121144. VBIEscCol129921_2960.

Organism-specific databases

EchoBASEi EB2862.
EcoGenei EG13050. xdhB.

Phylogenomic databases

eggNOGi COG1319.
HOGENOMi HOG000244729.
KOi K13479.
OMAi IVGNICR.
OrthoDBi EOG6ZSP3F.
PhylomeDBi Q46800.

Enzyme and pathway databases

UniPathwayi UPA00604 ; UER00661 .
UPA00604 ; UER00662 .
BioCyci EcoCyc:G7486-MONOMER.
ECOL316407:JW2835-MONOMER.
MetaCyc:G7486-MONOMER.

Miscellaneous databases

PROi Q46800.

Gene expression databases

Genevestigatori Q46800.

Family and domain databases

Gene3Di 3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
InterProi IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
[Graphical view ]
Pfami PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
[Graphical view ]
SMARTi SM01092. CO_deh_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55447. SSF55447. 1 hit.
SSF56176. SSF56176. 1 hit.
PROSITEi PS51387. FAD_PCMH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage."
    Xi H., Schneider B.L., Reitzer L.
    J. Bacteriol. 182:5332-5341(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF FUNCTION.
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Entry informationi

Entry nameiXDHB_ECOLI
AccessioniPrimary (citable) accession number: Q46800
Secondary accession number(s): Q2M9X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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