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Protein

Nucleoside-triphosphatase THEP1

Gene

Mbar_A3054

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.UniRule annotation

Catalytic activityi

NTP + H2O = NDP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPUniRule annotation8
Nucleotide bindingi99 – 106ATPUniRule annotation8

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside-triphosphatase THEP1UniRule annotation (EC:3.6.1.15UniRule annotation)
Short name:
NTPase THEP1UniRule annotation
Alternative name(s):
Nucleoside triphosphate phosphohydrolaseUniRule annotation
Gene namesi
Ordered Locus Names:Mbar_A3054
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000469531 – 174Nucleoside-triphosphatase THEP1Add BLAST174

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A3054.

Structurei

3D structure databases

ProteinModelPortaliQ467J7.
SMRiQ467J7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the THEP1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiVHKICSA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1. 1 hit.
InterProiIPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q467J7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRIAVTGIP GIGKSTVVAK AAEKLADQPG FKIGGIQTAE IRKEGQREGF
60 70 80 90 100
SIMDLATGKT GVLGSIRESG PRVGKYHVNL EDLEKIGANA LRSAMDCDLI
110 120 130 140 150
VIDEVGTMEL KSEAFVSAVK VVLESDKPVL AVLHRSSSHQ LVQRMRREFE
160 170
VLVVNEKNRD GLPGKIANRF REMR
Length:174
Mass (Da):18,995
Last modified:September 13, 2005 - v1
Checksum:iEF35886284D6AE7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ71945.1.
RefSeqiWP_011307985.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ71945; AAZ71945; Mbar_A3054.
GeneIDi3625065.
KEGGimba:Mbar_A3054.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ71945.1.
RefSeqiWP_011307985.1. NC_007355.1.

3D structure databases

ProteinModelPortaliQ467J7.
SMRiQ467J7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269797.Mbar_A3054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAZ71945; AAZ71945; Mbar_A3054.
GeneIDi3625065.
KEGGimba:Mbar_A3054.

Phylogenomic databases

eggNOGiarCOG01034. Archaea.
COG1618. LUCA.
HOGENOMiHOG000006446.
KOiK06928.
OMAiVHKICSA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00796. NTPase_1. 1 hit.
InterProiIPR004948. Nuc-triphosphatase_THEP1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF03266. NTPase_1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTPTH_METBF
AccessioniPrimary (citable) accession number: Q467J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: September 13, 2005
Last modified: November 2, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.