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Protein

Uncharacterized lipoprotein YgeR

Gene

ygeR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • autolysis Source: EcoliWiki
  • cell separation after cytokinesis Source: EcoliWiki
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7484-MONOMER.
ECOL316407:JW2833-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized lipoprotein YgeR
Gene namesi
Name:ygeR
Ordered Locus Names:b2865, JW2833
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13048. ygeR.

Subcellular locationi

  • Cell inner membrane Curated; Lipid-anchor PROSITE-ProRule annotation

  • Note: Slightly enriched at the septal ring.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Cells are shorter in a single mutant, while triple envC-nlpD-ygeR disruptions have defects in septation and cell separation and form long filaments (15-fold longer) and further yet by the quadruple disruption mutant (envC-nlpD-mepM(yebA)-ygeR, over 21-fold longer). Quadruple mutants are less sensitive to ampicillin lysis.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525PROSITE-ProRule annotationAdd
BLAST
Chaini26 – 251226Uncharacterized lipoprotein YgeRPRO_0000013776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi26 – 261N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi26 – 261S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ46798.

Interactioni

Protein-protein interaction databases

BioGridi4262318. 168 interactions.
DIPiDIP-36034N.
IntActiQ46798. 5 interactions.
STRINGi511145.b2865.

Structurei

3D structure databases

ProteinModelPortaliQ46798.
SMRiQ46798. Positions 39-91, 129-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 8445LysMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M23B family.Curated
Contains 1 LysM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108K5P. Bacteria.
COG0739. LUCA.
HOGENOMiHOG000159026.
InParanoidiQ46798.
KOiK12943.
OMAiIMIKHGE.
OrthoDBiEOG6GXV0B.
PhylomeDBiQ46798.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018392. LysM_dom.
IPR016047. Peptidase_M23.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF01551. Peptidase_M23. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46798-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGRLNKKS LGIVMLLSVG LLLAGCSGSK SSDTGTYSGS VYTVKRGDTL
60 70 80 90 100
YRISRTTGTS VKELARLNGI SPPYTIEVGQ KLKLGGAKSS SITRKSTAKS
110 120 130 140 150
TTKTASVTPS SAVPKSSWPP VGQRCWLWPT TGKVIMPYST ADGGNKGIDI
160 170 180 190 200
SAPRGTPIYA AGAGKVVYVG NQLRGYGNLI MIKHSEDYIT AYAHNDTMLV
210 220 230 240 250
NNGQSVKAGQ KIATMGSTDA ASVRLHFQIR YRATAIDPLR YLPPQGSKPK

C
Length:251
Mass (Da):26,565
Last modified:March 27, 2002 - v2
Checksum:iFCD6235D39790475
GO

Sequence cautioni

The sequence AAA83046.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83046.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75903.2.
AP009048 Genomic DNA. Translation: BAE76931.1.
PIRiA65070.
RefSeqiNP_417341.4. NC_000913.3.
WP_001301085.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75903; AAC75903; b2865.
BAE76931; BAE76931; BAE76931.
GeneIDi947352.
KEGGiecj:JW2833.
eco:b2865.
PATRICi32121140. VBIEscCol129921_2958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83046.1. Different initiation.
U00096 Genomic DNA. Translation: AAC75903.2.
AP009048 Genomic DNA. Translation: BAE76931.1.
PIRiA65070.
RefSeqiNP_417341.4. NC_000913.3.
WP_001301085.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliQ46798.
SMRiQ46798. Positions 39-91, 129-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262318. 168 interactions.
DIPiDIP-36034N.
IntActiQ46798. 5 interactions.
STRINGi511145.b2865.

Proteomic databases

PaxDbiQ46798.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75903; AAC75903; b2865.
BAE76931; BAE76931; BAE76931.
GeneIDi947352.
KEGGiecj:JW2833.
eco:b2865.
PATRICi32121140. VBIEscCol129921_2958.

Organism-specific databases

EchoBASEiEB2860.
EcoGeneiEG13048. ygeR.

Phylogenomic databases

eggNOGiENOG4108K5P. Bacteria.
COG0739. LUCA.
HOGENOMiHOG000159026.
InParanoidiQ46798.
KOiK12943.
OMAiIMIKHGE.
OrthoDBiEOG6GXV0B.
PhylomeDBiQ46798.

Enzyme and pathway databases

BioCyciEcoCyc:G7484-MONOMER.
ECOL316407:JW2833-MONOMER.

Miscellaneous databases

PROiQ46798.

Family and domain databases

Gene3Di3.10.350.10. 1 hit.
InterProiIPR011055. Dup_hybrid_motif.
IPR018392. LysM_dom.
IPR016047. Peptidase_M23.
[Graphical view]
PfamiPF01476. LysM. 1 hit.
PF01551. Peptidase_M23. 1 hit.
[Graphical view]
SMARTiSM00257. LysM. 1 hit.
[Graphical view]
SUPFAMiSSF51261. SSF51261. 1 hit.
PROSITEiPS51782. LYSM. 1 hit.
PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "LytM-domain factors are required for daughter cell separation and rapid ampicillin-induced lysis in Escherichia coli."
    Uehara T., Dinh T., Bernhardt T.G.
    J. Bacteriol. 191:5094-5107(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    Strain: K12 / MG1655 / TB28.

Entry informationi

Entry nameiYGER_ECOLI
AccessioniPrimary (citable) accession number: Q46798
Secondary accession number(s): Q2M9X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: January 20, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.