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Q46759 (Q46759_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified May 31, 2011. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
Beta-lactamase EMBL AAA87176.1
Gene names
Name:SHV-7 EMBL AAA87176.1
OrganismEscherichia coli EMBL AAA87176.1
Taxonomic identifier562 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

A beta-lactam + H2O = a substituted beta-amino acid. SAAS SAAS012338

Ontologies

Keywords
   Biological processAntibiotic resistance SAAS SAAS012338
   Molecular functionHydrolase SAAS SAAS023650
Gene Ontology (GO)
   Biological processbeta-lactam antibiotic catabolic process

Inferred from electronic annotation. Source: InterPro

response to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionbeta-lactamase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q46759 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 65DC41A079DC5943

FASTA28631,218
        10         20         30         40         50         60 
MRYFRLCIIS LLATLPLAVH ASPQPLEQIK LSESQLSGSV GMIEMDLASG RTLTAWRADE 

        70         80         90        100        110        120 
RFPMMSTFKV VLCGAVLARV DAGDEQLERK IHYRQQDLVD YSPVSEKHLA DGMTVGELCA 

       130        140        150        160        170        180 
AAITMSDNSA ANLLLATVGG PAGLTAFLRQ IGDNVTRLDR WETELNEALP GDARDTTTPA 

       190        200        210        220        230        240 
SMAATLRKLL TSQRLSARSQ RQLLQWMVDD RVAGPLIRSV LPAGWFIADK TGASKRGARG 

       250        260        270        280 
IVALLGPNNK AERIVVIYLR DTPASMAERN QQIAGIGAAL IEHWQR

« Hide

References

[1]"SHV-7, a novel cefotaxime-hydrolyzing beta-lactamase, identified in Escherichia coli isolates from hospitalized nursing home patients."
Bradford P.A., Urban C., Jaiswal A., Mariano N., Rasmussen B.A., Projan S.J., Rahal J.J., Bush K.
Antimicrob. Agents Chemother. 39:899-905(1995) [PubMed: 7785992] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U20270 Genomic DNA. Translation: AAA87176.1.

3D structure databases

HSSPHSSP built from PDB template 1N9B based on UniProtKB P30896.
ProteinModelPortalQ46759.
SMRQ46759. Positions 22-286.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001466. Beta-lactam-related.
IPR012338. Beta-lactam/transpept-like.
IPR000871. Beta-lactam_class-A/D.
IPR023650. Beta-lactam_class-A_AS.
[Graphical view]
Gene3DG3DSA:3.40.710.10. G3DSA:3.40.710.10. 1 hit.
PfamPF00144. Beta-lactamase. 1 hit.
[Graphical view]
PRINTSPR00118. BLACTAMASEA.
SUPFAMSSF56601. PBP_transp_fold. 1 hit.
PROSITEPS00146. BETA_LACTAMASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ46759_ECOLX
AccessionPrimary (citable) accession number: Q46759
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 31, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info