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Protein
Submitted name:

Hemolysin A

Gene

EHEC-hlyA

Organism
Escherichia coli O157:H7
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Hemolysin AImported
Submitted name:
Hemolysin toxin proteinImported
Gene namesi
Name:EHEC-hlyAImported
Synonyms:hlyAImported
ORF Names:Z_L7048Imported
Encoded oniPlasmid pO157Imported
OrganismiEscherichia coli O157:H7Imported
Taxonomic identifieri83334 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000558 Componenti: Plasmid pO157
  • UP000002519 Componenti: Plasmid pO157

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi155864.L7048.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 641RTXInterPro annotationAdd BLAST631
Domaini855 – 992RTX_CInterPro annotationAdd BLAST138

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG4107W46. Bacteria.
ENOG410XQTW. LUCA.
HOGENOMiHOG000249587.
KOiK11005.
OMAiRQNYGHH.

Family and domain databases

Gene3Di2.150.10.10. 1 hit.
InterProiIPR018511. Hemolysin-typ_Ca-bd_CS.
IPR001343. Hemolysn_Ca-bd.
IPR013550. RTX_C.
IPR018504. RTX_N.
IPR003995. RTX_toxin_determinant-A.
IPR011049. Serralysin-like_metalloprot_C.
[Graphical view]
PfamiPF00353. HemolysinCabind. 6 hits.
PF02382. RTX. 1 hit.
PF08339. RTX_C. 1 hit.
[Graphical view]
PRINTSiPR01488. RTXTOXINA.
SUPFAMiSSF51120. SSF51120. 1 hit.
PROSITEiPS00330. HEMOLYSIN_CALCIUM. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46716-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVNKIKNIF NNATLTTKSA FNTASSSVRS AGKKLILLIP DNYEAQGVGI
60 70 80 90 100
NELVKAADEL GIEIHRTERD DTAIANQFFG AAEKVVGLTE RGVAIFAPQL
110 120 130 140 150
DKLLQKYQKV GSKIGGTAEN VGNNLGKAGT VLSALQNFTG IALSGMALDE
160 170 180 190 200
LLRKQREGED ISQNDIAKSS IELINQLVDT VSSINSTVDS FSEQLNQLGS
210 220 230 240 250
FLSSKPRLSS VGGKLQNLPD LGPLGDGLDV VSGILSAVSA SFILGNSDAH
260 270 280 290 300
TGTKAAAGIE LTTQVLGNVG KAVSQYILAQ RMAQGLSTTA ASAGLITSAV
310 320 330 340 350
MLAISPLSFL AAADKFERAK QLESYSERFK KLNYEGDALL AAFHKETGAI
360 370 380 390 400
DAALTTINTV LSSVSAGVSA ASSASLIGAP ISMLVSALTG TISGILEASK
410 420 430 440 450
QAMFEHVAEK FAARINEWEK EHGKNYFENG YDARHAAFLE DSLSLLADFS
460 470 480 490 500
RQHAVERAVA ITQQHWDEKI GELAGITRNA DRSQSGKAYI NYLENGGLLE
510 520 530 540 550
AQPKEFTQQV FDPQKGTIDL STGNVSSVLT FITPTFTPGE EVRERKQSGK
560 570 580 590 600
YEYMTSLIVN GKDTWSVKGI KNHKGVYDYS KLIQFVEKNN KHYQARIISE
610 620 630 640 650
LGDKDDVVYS GAGSSEVFAG EGYDTVSYNK TDVGKLTIDA TGASKPGEYI
660 670 680 690 700
VSKNMYGDVK VLQEVVKEQE VSVGKRTEKI QYRDFEFRTG GIPYDVIDNL
710 720 730 740 750
HSVEELIGGK HDDEFKGGKF NDIFHGADGN DYIEGNYGND RLYGDDGDDY
760 770 780 790 800
ISGGQGDDQL FGGSGNDKLS GGDGNNYLTG GSGNDELQAH GAYNILSGGT
810 820 830 840 850
GDDKLYGGGG IDLLDGGEGN DYLNGGFGND IYVYGQNYGH HTIADEGGKG
860 870 880 890 900
DRLHLSDISF DDIAFKRVGN DLIMNKAING VLSFNESNDV NGITFKNWFA
910 920 930 940 950
KDASGADNHL VEVITDKDGR EIKVDKIPHN NNERSGYIKA SNIASEKNMV
960 970 980 990
NITSVANDIN KIISSVSGFD SGDERLASLY NLSLHQNNTH STTLTTTV
Length:998
Mass (Da):107,048
Last modified:May 1, 1999 - v2
Checksum:iBB3C0D36FCBB9EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074613 Genomic DNA. Translation: AAC70116.1.
AB011549 Genomic DNA. Translation: BAA31774.1.
PIRiT00227.
RefSeqiNP_052624.1. NC_002128.1.
WP_000217739.1. NZ_LKAL01000035.1.

Genome annotation databases

EnsemblBacteriaiAAC70116; AAC70116; Z_L7048.
BAA31774; BAA31774; BAA31774.
GeneIDi1789686.
KEGGiece:Z_L7048.
ecs:pO157p18.
PATRICi18360465. VBIEscCol44059_5634.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074613 Genomic DNA. Translation: AAC70116.1.
AB011549 Genomic DNA. Translation: BAA31774.1.
PIRiT00227.
RefSeqiNP_052624.1. NC_002128.1.
WP_000217739.1. NZ_LKAL01000035.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi155864.L7048.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC70116; AAC70116; Z_L7048.
BAA31774; BAA31774; BAA31774.
GeneIDi1789686.
KEGGiece:Z_L7048.
ecs:pO157p18.
PATRICi18360465. VBIEscCol44059_5634.

Phylogenomic databases

eggNOGiENOG4107W46. Bacteria.
ENOG410XQTW. LUCA.
HOGENOMiHOG000249587.
KOiK11005.
OMAiRQNYGHH.

Family and domain databases

Gene3Di2.150.10.10. 1 hit.
InterProiIPR018511. Hemolysin-typ_Ca-bd_CS.
IPR001343. Hemolysn_Ca-bd.
IPR013550. RTX_C.
IPR018504. RTX_N.
IPR003995. RTX_toxin_determinant-A.
IPR011049. Serralysin-like_metalloprot_C.
[Graphical view]
PfamiPF00353. HemolysinCabind. 6 hits.
PF02382. RTX. 1 hit.
PF08339. RTX_C. 1 hit.
[Graphical view]
PRINTSiPR01488. RTXTOXINA.
SUPFAMiSSF51120. SSF51120. 1 hit.
PROSITEiPS00330. HEMOLYSIN_CALCIUM. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ46716_ECO57
AccessioniPrimary (citable) accession number: Q46716
Secondary accession number(s): A0A0T7C0Z3, Q7BSV1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported, PlasmidImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.