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Protein
Submitted name:

Endonuclease

Gene

nuc

Organism
Escherichia coli
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. endonuclease activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseImported, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Submitted name:
EndonucleaseImported
Submitted name:
NucImported
Submitted name:
Plasmid conjugative transfer endonucleaseImported
Submitted name:
Strain O157 SvETEC scaffold119.1, whole genome shotgun sequenceImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:nucImported
ORF Names:IY32_26605Imported, pKC394-032Imported, pKC396-025Imported, pMUR050_045Imported, PU53_15785Imported
Encoded oniPlasmid pH1038-142Imported
Plasmid pHHA45Imported
Plasmid pKC394Imported
Plasmid pKC396Imported
Plasmid pKM101Imported
Plasmid pL2-43Imported
Plasmid pLEW517Imported
Plasmid pMUR050Imported
Plasmid pQNR2078Imported
OrganismiEscherichia coliImported
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BYRX-ray2.00A23-177[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLATWLLA AAFTTAALPA FAVEPSVQVG YSPEGSARVL VLSAIDSAKT
60 70 80 90 100
SIRMMAYSFT APDIMKALVA AKKRGVDVKI VIDERGNTGR ASIAAMNYIA
110 120 130 140 150
NSGIPLRTDS NFPIQHDKVI IVDNVTVETG SFNFTKAAET KNSENAVVIW
160 170
NMPKLAESFL EHWQDRWNQG RDYRSSY
Length:177
Mass (Da):19,445
Last modified:November 1, 1996 - v1
Checksum:iE0EFD6133C328F3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09868 Genomic DNA. Translation: AAA86461.1.
AY522431 Genomic DNA. Translation: ABG33821.1.
DQ390454 Genomic DNA. Translation: ABG49201.1.
HM138652 Genomic DNA. Translation: ADH29990.1.
HM138653 Genomic DNA. Translation: ADH30040.1.
JX065630 Genomic DNA. Translation: AFP24965.1.
KJ484634 Genomic DNA. Translation: AIF78280.1.
KJ484641 Genomic DNA. Translation: AIF79346.1.
HE613857 Genomic DNA. Translation: CCE73956.1.
JWZA01000027 Genomic DNA. Translation: KIG51094.1.
JPPP01000119 Genomic DNA. Translation: KIQ43536.1.
PIRiI79276.
RefSeqiYP_001096362.1. NC_009132.1.
YP_003717504.1. NC_014231.1.
YP_006903017.1. NC_019033.1.
YP_006953730.1. NC_019087.1.
YP_006954498.1. NC_019098.1.
YP_009061039.1. NC_024974.1.
YP_009068534.1. NC_025141.1.
YP_009074498.1. NG_034648.1.
YP_724502.1. NC_007682.3.

Genome annotation databases

GeneIDi13897318.
13906676.
13909226.
20468083.
20491666.
3861224.
4924687.
9284748.
KEGGipg:13897318.
pg:13906676.
pg:13909226.
pg:20468083.
pg:20491666.
pg:3861224.
pg:4924687.
pg:9284748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09868 Genomic DNA. Translation: AAA86461.1.
AY522431 Genomic DNA. Translation: ABG33821.1.
DQ390454 Genomic DNA. Translation: ABG49201.1.
HM138652 Genomic DNA. Translation: ADH29990.1.
HM138653 Genomic DNA. Translation: ADH30040.1.
JX065630 Genomic DNA. Translation: AFP24965.1.
KJ484634 Genomic DNA. Translation: AIF78280.1.
KJ484641 Genomic DNA. Translation: AIF79346.1.
HE613857 Genomic DNA. Translation: CCE73956.1.
JWZA01000027 Genomic DNA. Translation: KIG51094.1.
JPPP01000119 Genomic DNA. Translation: KIQ43536.1.
PIRiI79276.
RefSeqiYP_001096362.1. NC_009132.1.
YP_003717504.1. NC_014231.1.
YP_006903017.1. NC_019033.1.
YP_006953730.1. NC_019087.1.
YP_006954498.1. NC_019098.1.
YP_009061039.1. NC_024974.1.
YP_009068534.1. NC_025141.1.
YP_009074498.1. NG_034648.1.
YP_724502.1. NC_007682.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BYRX-ray2.00A23-177[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13897318.
13906676.
13909226.
20468083.
20491666.
3861224.
4924687.
9284748.
KEGGipg:13897318.
pg:13906676.
pg:13909226.
pg:20468083.
pg:20491666.
pg:3861224.
pg:4924687.
pg:9284748.

Family and domain databases

InterProiIPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF13091. PLDc_2. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 1 hit.
[Graphical view]
PROSITEiPS50035. PLD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens."
    Pohlman R.F., Genetti H.D., Winans S.C.
    Mol. Microbiol. 14:655-668(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pKM101
  2. "Entry exclusion of the IncN plasmid pKM101 is mediated by a single hydrophilic protein containing a lipid attachment motif."
    Pohlman R.F., Genetti H.D., Winans S.C.
    Plasmid 31:158-165(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pKM101
  3. "Crystal structure of a phospholipase D family member."
    Stuckey J.A., Dixon J.E.
    Nat. Struct. Biol. 6:278-284(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 23-177.
  4. "armA and aminoglycoside resistance in Escherichia coli."
    Gonzalez-Zorn B., Teshager T., Casas M., Porrero M.C., Moreno M.A., Courvalin P., Dominguez L.
    Emerg. Infect. Dis. 11:954-956(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pMUR050
  5. Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pMUR050
  6. "Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing."
    Williams L.E., Detter C., Barry K., Lapidus A., Summers A.O.
    Appl. Environ. Microbiol. 72:4899-4906(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 517-2H1Imported.
    Plasmid: pLEW517
  7. Gonzalez-Zorn B., Catalan A., Moreno M.A., Dominguez L.
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Plasmid: pMUR050
  8. "A novel IS26 structure surrounds blaCTX-M genes in different plasmids from German clinical Escherichia coli isolates."
    Cullik A., Pfeifer Y., Prager R., von Baum H., Witte W.
    J. Med. Microbiol. 59:580-587(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ST131Imported.
    Plasmid: pKC394 pKC396
  9. Schwarz S.P.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2078Imported.
    Plasmid: pQNR2078
  10. "Detection of qnr genes among Escherichia coli isolates of animal origin and complete sequence of the conjugative qnrB19-carrying plasmid pQNR2078."
    Schink A.K., Kadlec K., Schwarz S.
    J. Antimicrob. Chemother. 67:1099-1102(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 2078Imported.
    Plasmid: pQNR2078
  11. "Characterization of IncN plasmids carrying blaCTX-M-1 and qnr genes in Escherichia coli and Salmonella from animals, the environment and humans."
    Dolejska M., Villa L., Hasman H., Hansen L., Carattoli A.
    J. Antimicrob. Chemother. 68:333-339(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: HHA45Imported.
    Plasmid: pHHA45
  12. "Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans."
    Wang J., Stephan R., Power K., Yan Q., Hachler H., Fanning S.
    J. Antimicrob. Chemother. 69:2658-2668(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Human-1038Imported and Lamb-2Imported.
    Plasmid: pH1038-142 pL2-43
  13. "Comparative Genomic Analysis of an Enterotoxigenic E. coli O157 Lineage from Australian Pigs."
    Wyrsch E., Roy Chowdhury P., Abraham S., Santos J., Darling A., Charles I., Chapman T., Djordjevic S.
    Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: O157 SvETECImported.
  14. "Whole-genome sequencing effectively predicts antimicrobial resistance phenotypes of E. coli."
    Tyson G.H., McDermott P.F., Li C., Tadesse D.A., Mukherjee S., Bodeis-Jones S., Kabera C., Gaines S.A., Loneragan G.H., Edrington T.S., Torrence M., Harhay D.M., Zhao S.
    Submitted (NOV-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CVM N36601PSImported.

Entry informationi

Entry nameiQ46707_ECOLX
AccessioniPrimary (citable) accession number: Q46707
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, PlasmidImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.