Q46707 (Q46707_ECOLX) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Endonuclease EMBL AAA86461.1

Submitted name:
Nuc EMBL AFP24965.1

Gene names

Name:	nuc EMBL AAA86461.1
ORF Names:	pKC394-032 EMBL ADH29990.1, pKC396-025 EMBL ADH30040.1, pMUR050_045 EMBL ABG33821.1

Encoded on

Plasmid pKC394 Ref.3 Ref.8 Ref.9 EMBL ADH29990.1
Plasmid pQNR2078 Ref.3 Ref.10 Ref.11 EMBL CCE73956.1
Plasmid pMUR050 Ref.3 Ref.4 Ref.5 Ref.7 EMBL ABG33821.1
Plasmid pKC396 Ref.3 Ref.8 Ref.9 EMBL ADH30040.1
Plasmid pLEW517 Ref.3 Ref.6 EMBL ABG49201.1
Plasmid pHHA45 Ref.3 Ref.12 EMBL AFP24965.1
Plasmid pKM101 Ref.1 Ref.2 Ref.3 EMBL AAA86461.1

Organism

Escherichia coli EMBL AAA86461.1

Taxonomic identifier

562 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Molecular function	Endonuclease EMBL AAA86461.1 Hydrolase Nuclease
Technical term	3D-structure PDB 1BYS PDB 1BYR Plasmid EMBL AAA86461.1
Gene Ontology (GO)
Molecular_function	endonuclease activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q46707 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E0EFD6133C328F3E	FASTA	177	19,445
	10 20 30 40 50 60 MKKLATWLLA AAFTTAALPA FAVEPSVQVG YSPEGSARVL VLSAIDSAKT SIRMMAYSFT 70 80 90 100 110 120 APDIMKALVA AKKRGVDVKI VIDERGNTGR ASIAAMNYIA NSGIPLRTDS NFPIQHDKVI 130 140 150 160 170 IVDNVTVETG SFNFTKAAET KNSENAVVIW NMPKLAESFL EHWQDRWNQG RDYRSSY

References

[1]	"Common ancestry between IncN conjugal transfer genes and macromolecular export systems of plant and animal pathogens." Pohlman R.F., Genetti H.D., Winans S.C. Mol. Microbiol. 14:655-668(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Entry exclusion of the IncN plasmid pKM101 is mediated by a single hydrophilic protein containing a lipid attachment motif." Pohlman R.F., Genetti H.D., Winans S.C. Plasmid 31:158-165(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Crystal structure of a phospholipase D family member." Stuckey J.A., Dixon J.E. Nat. Struct. Biol. 6:278-284(1999) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 23-177.
[4]	"armA and aminoglycoside resistance in Escherichia coli." Gonzalez-Zorn B., Teshager T., Casas M., Porrero M.C., Moreno M.A., Courvalin P., Dominguez L. Emerg. Infect. Dis. 11:954-956(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[5]	"Genetic basis for dissemination of armA." Gonzalez-Zorn B., Catalan A., Escudero J.A., Dominguez L., Teshager T., Porrero C., Moreno M.A. J. Antimicrob. Chemother. 56:583-585(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[6]	"Facile recovery of individual high-molecular-weight, low-copy-number natural plasmids for genomic sequencing." Williams L.E., Detter C., Barry K., Lapidus A., Summers A.O. Appl. Environ. Microbiol. 72:4899-4906(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 517-2H1 EMBL ABG49201.1.
[7]	Gonzalez-Zorn B., Catalan A., Moreno M.A., Dominguez L. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[8]	"A novel IS26 structure surrounds blaCTX-M genes in different plasmids from German clinical Escherichia coli isolates." Cullik A., Pfeifer Y., Prager R., von Baum H., Witte W. J. Med. Microbiol. 59:580-587(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ST131 EMBL ADH29990.1.
[9]	"Complete nucleotide sequences of pKC394 and pKC396 harbouring multiple blaCTX M genes and their relationship to other IncN resistance plasmids." Cullik A., Witte W. Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ST131 EMBL ADH29990.1.
[10]	Schwarz S.P. Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 2078 EMBL CCE73956.1.
[11]	"Detection of qnr genes among Escherichia coli isolates of animal origin and complete sequence of the conjugative qnrB19-carrying plasmid pQNR2078." Schink A.K., Kadlec K., Schwarz S. J. Antimicrob. Chemother. 67:1099-1102(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 2078 EMBL CCE73956.1.
[12]	"Characterization of IncN plasmids carrying blaCTX-M-1 and qnr genes in Escherichia coli and Salmonella from animals, the environment and humans." Dolejska M., Villa L., Hasman H., Hansen L., Carattoli A. J. Antimicrob. Chemother. 68:333-339(2013) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: HHA45 EMBL AFP24965.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U09868 Genomic DNA. Translation: AAA86461.1.
AY522431 Genomic DNA. Translation: ABG33821.1.
DQ390454 Genomic DNA. Translation: ABG49201.1.
HM138652 Genomic DNA. Translation: ADH29990.1.
HM138653 Genomic DNA. Translation: ADH30040.1.
JX065630 Genomic DNA. Translation: AFP24965.1.
HE613857 Genomic DNA. Translation: CCE73956.1.

PIR

I79276.

RefSeq

YP_001096362.1. NC_009132.1.
YP_003717504.1. NC_014231.1.
YP_006903017.1. NC_019033.1.
YP_006953730.1. NC_019087.1.
YP_006954498.1. NC_019098.1.
YP_724502.1. NC_007682.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1BYR	X-ray	2.00	A	23-177	[»]
1BYS	X-ray	2.00	A	23-177	[»]

SMR

Q46707. Positions 24-175.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

13897318.
13906676.
13909226.
3861224.
4924687.
9284748.

Phylogenomic databases

ProtClustDB

CLSK896431.

Family and domain databases

InterPro

IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]

Pfam

PF13091. PLDc_2. 1 hit.
[Graphical view]

SMART

SM00155. PLDc. 1 hit.
[Graphical view]

PROSITE

PS50035. PLD. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q46707.

Entry information

Entry name

Q46707_ECOLX

Accession

Primary (citable) accession number: Q46707

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)