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Protein

AMP phosphorylase

Gene

Mbar_A3188

Organism
Methanosarcina barkeri (strain Fusaro / DSM 804)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei167AMP; via amide nitrogenUniRule annotation1
Binding sitei202AMP; via amide nitrogenUniRule annotation1
Active sitei255Proton donorUniRule annotation1
Binding sitei263AMPUniRule annotation1
Binding sitei287AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi193 – 198AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:Mbar_A3188
OrganismiMethanosarcina barkeri (strain Fusaro / DSM 804)
Taxonomic identifieri269797 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000008156 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002256451 – 506AMP phosphorylaseAdd BLAST506

Interactioni

Protein-protein interaction databases

STRINGi269797.Mbar_A3188.

Structurei

3D structure databases

ProteinModelPortaliQ466X0.
SMRiQ466X0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013. Archaea.
COG0213. LUCA.
HOGENOMiHOG000252767.
KOiK18931.
OMAiVHSIGGV.
OrthoDBiPOG093Z01M3.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase. 1 hit.
InterProiView protein in InterPro
IPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
IPR000053. Thymidine/pyrmidine_PPase.
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiView protein in Pfam
PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiView protein in SMART
SM00941. PYNP_C. 1 hit.
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiView protein in PROSITE
PS00647. THYMID_PHOSPHORYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q466X0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLKLEHFNI KIGQHKILLN IADAKELGVN PGDRVRIRGR ESISAIADTT
60 70 80 90 100
DDMVPPGTLG VFSEVYEHFV NWDKPVEVVP AFRSKSASVI KKMMDKKPVV
110 120 130 140 150
QEEIKTLVND IVEENLSEIE LSAFITSSYI HGMTDDEVEW LTRAMIESGD
160 170 180 190 200
TIEFDTHPIM DKHSIGGVPG NKISLLVVPI IAANGLLIPK TSSRAITGAG
210 220 230 240 250
GTADLMEVLC PVEFSSQEVK EITEKVGGAL VWGGATNIAP ADDKLIRVEY
260 270 280 290 300
PLSIDPYYQM LASIMAKKGA IGADNVVMDI PVGPSTKVPT VQEGQKLARD
310 320 330 340 350
LINLGHRLGM NVECAITYGS SPIGRKVGPS LEVREALKVL ESMEGPNSLI
360 370 380 390 400
EKSAALAGIL LEMGGAAPRD RGKEIALETL RSGKALEKMK QIIEAQGGDP
410 420 430 440 450
KITSADIQVG QYTADILASA DGYVIEFDNK WIIEIARLAG APNDKGAGVA
460 470 480 490 500
IHKKMGESVK KGDPILTIYA EKEFKLETAL ATAQRTNPIV VEGMLLKRIP

GTYGFQ
Length:506
Mass (Da):54,628
Last modified:September 13, 2005 - v1
Checksum:iCA65A31C8EDAE32E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000099 Genomic DNA. Translation: AAZ72072.1.
RefSeqiWP_011308112.1. NC_007355.1.

Genome annotation databases

EnsemblBacteriaiAAZ72072; AAZ72072; Mbar_A3188.
GeneIDi3627130.
KEGGimba:Mbar_A3188.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAMPPA_METBF
AccessioniPrimary (citable) accession number: Q466X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 13, 2005
Last modified: June 7, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families