Q466X0 (TYPH_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

Mbar_A3188

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina barkeri

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 506	506	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_0000225645

Sequences

	Sequence		Length	Mass (Da)
	Q466X0 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: CA65A31C8EDAE32E	FASTA	506	54,628
	10 20 30 40 50 60 MQLKLEHFNI KIGQHKILLN IADAKELGVN PGDRVRIRGR ESISAIADTT DDMVPPGTLG 70 80 90 100 110 120 VFSEVYEHFV NWDKPVEVVP AFRSKSASVI KKMMDKKPVV QEEIKTLVND IVEENLSEIE 130 140 150 160 170 180 LSAFITSSYI HGMTDDEVEW LTRAMIESGD TIEFDTHPIM DKHSIGGVPG NKISLLVVPI 190 200 210 220 230 240 IAANGLLIPK TSSRAITGAG GTADLMEVLC PVEFSSQEVK EITEKVGGAL VWGGATNIAP 250 260 270 280 290 300 ADDKLIRVEY PLSIDPYYQM LASIMAKKGA IGADNVVMDI PVGPSTKVPT VQEGQKLARD 310 320 330 340 350 360 LINLGHRLGM NVECAITYGS SPIGRKVGPS LEVREALKVL ESMEGPNSLI EKSAALAGIL 370 380 390 400 410 420 LEMGGAAPRD RGKEIALETL RSGKALEKMK QIIEAQGGDP KITSADIQVG QYTADILASA 430 440 450 460 470 480 DGYVIEFDNK WIIEIARLAG APNDKGAGVA IHKKMGESVK KGDPILTIYA EKEFKLETAL 490 500 ATAQRTNPIV VEGMLLKRIP GTYGFQ

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ72072.1.
RefSeq	YP_306652.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q466X0.
ModBase	Search...
Protein-protein interaction databases
STRING	269797.Mbar_A3188.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAZ72072; AAZ72072; Mbar_A3188.
GeneID	3627130.
KEGG	mba:Mbar_A3188.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Enzyme and pathway databases
BioCyc	MBAR269797:GHUW-3258-MONOMER.
Family and domain databases
Gene3D	3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_METBF

Accession

Primary (citable) accession number: Q466X0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	September 13, 2005
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program