ID   Q466Q7_METBF            Unreviewed;       253 AA.
AC   Q466Q7;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   27-MAR-2024, entry version 90.
DE   RecName: Full=4-phosphopantoate--beta-alanine ligase {ECO:0000256|HAMAP-Rule:MF_02224};
DE            EC=6.3.2.36 {ECO:0000256|HAMAP-Rule:MF_02224};
DE   AltName: Full=Phosphopantothenate synthetase {ECO:0000256|HAMAP-Rule:MF_02224};
DE            Short=PPS {ECO:0000256|HAMAP-Rule:MF_02224};
GN   OrderedLocusNames=Mbar_A3254 {ECO:0000313|EMBL:AAZ72135.1};
OS   Methanosarcina barkeri (strain Fusaro / DSM 804).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=269797 {ECO:0000313|EMBL:AAZ72135.1};
RN   [1] {ECO:0000313|EMBL:AAZ72135.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Fusaro {ECO:0000313|EMBL:AAZ72135.1};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Goodwin L.A., Saunders E.H., Schmutz J.,
RA   Larimer F., Land M., Anderson I., Richardson P.;
RT   "Complete sequence of chromosome 1 of Methanosarcina barkeri str. fusaro.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the condensation of (R)-4-phosphopantoate and beta-
CC       alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.
CC       {ECO:0000256|HAMAP-Rule:MF_02224}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-
CC         phosphopantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:27930,
CC         ChEBI:CHEBI:10986, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:61294,
CC         ChEBI:CHEBI:456215; EC=6.3.2.36; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02224};
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02224}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_02224}.
CC   -!- SIMILARITY: Belongs to the archaeal phosphopantothenate synthetase
CC       family. {ECO:0000256|HAMAP-Rule:MF_02224}.
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DR   EMBL; CP000099; AAZ72135.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q466Q7; -.
DR   STRING; 269797.Mbar_A3254; -.
DR   PaxDb; 269797-Mbar_A3254; -.
DR   KEGG; mba:Mbar_A3254; -.
DR   eggNOG; arCOG04262; Archaea.
DR   HOGENOM; CLU_078701_0_0_2; -.
DR   OrthoDB; 10078at2157; -.
DR   UniPathway; UPA00241; -.
DR   GO; GO:0016881; F:acid-amino acid ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.12640; Phosphopantoate/pantothenate synthetase; 1.
DR   HAMAP; MF_02224; PPS; 1.
DR   InterPro; IPR002855; PPS/PS.
DR   InterPro; IPR038138; PPS/PS_sf.
DR   NCBIfam; NF041123; phpantohe_syn_Arch; 1.
DR   PANTHER; PTHR40695; 4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE; 1.
DR   PANTHER; PTHR40695:SF1; 4-PHOSPHOPANTOATE--BETA-ALANINE LIGASE; 1.
DR   Pfam; PF02006; PPS_PS; 1.
DR   PIRSF; PIRSF004853; UCP004853; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_02224};
KW   Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993, ECO:0000256|HAMAP-
KW   Rule:MF_02224};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_02224};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_02224}.
FT   BINDING         17
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02224"
FT   BINDING         39
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02224"
FT   BINDING         179..181
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02224"
FT   BINDING         185..186
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02224"
FT   BINDING         197..198
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02224"
SQ   SEQUENCE   253 AA;  27799 MW;  D0E7942A1CDC00C4 CRC64;
     MTEIPKDHPR YESLLAREKV AAGVKMGITS VQGLISQGRG ESFDYLIGER STKSALYAER
     AAVAALLLAK NPVISVNGNA AVLAPDKIVA LADVTEAKLE VNLFHRTETR VHLIIEQLKA
     NGASEVLGKN PDVSLELSHA RRLVESRGIY SADVVLVPLE DGDRCEKLVE MGKTVIAIDL
     NPLSRTSKMA TISIVDNLTR ALENMIKFGV ELKKERNEEL VKLITTYDNK KVLIEAISEI
     QENLKAMTVE LEQ
//