Q466H2 (ADEC_METBF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	Mbar_A3342

Organism

Methanosarcina barkeri (strain Fusaro / DSM 804) [Complete proteome] [HAMAP]

Taxonomic identifier

269797 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	Adenine deaminase HAMAP MF_01518		PRO_0000296736

Sequences

	Sequence		Length	Mass (Da)
	Q466H2 [UniParc]. Last modified September 13, 2005. Version 1. Checksum: 29C26A3E9646A7EF	FASTA	551	60,380
	10 20 30 40 50 60 MQTYQGIIVD AIYRRKFKGE IAVEHGKIIS IEEKEHDIEQ YILPGLVDAH VHIESSMTVP 70 80 90 100 110 120 SVFARMAVAR GTVAVVSDPH EIANVMGEEG IDYMLEDARK APLKVFFGVP SCVPATPFES 130 140 150 160 170 180 AGAVLDAEAV DRLLAREDLH YLSEMMNFPG VVMEFPEVIA KLESAKKYGK NIDGHAPGLN 190 200 210 220 230 240 GTDLQKYVGA GISTDHESFA YEEAVEKIKL GMNILIREGS SARNFDTLYK LIDEYPESVM 250 260 270 280 290 300 LCTDDSHPDT LIYEGHIDKL LRRGQEKGLD IYNLIRAAVI NPVEHYGLNV GLLREGDPAD 310 320 330 340 350 360 FIIVDDLKAF NVLKTFIDGS CVYNDGKVLF SVEQAPAKNV FNRNKISVDD VKLAMPASGN 370 380 390 400 410 420 NGEQMKKIRV IVAQDGELVT GQELALPKVE NGNLISDPAR DILKMVVLSR YADDPVQIGF 430 440 450 460 470 480 IKNIGLKKGA IASSIAHDSH NIIAVGATDE DIVGAVNRLV ENRGGIVVGT ADNLIDLPLE 490 500 510 520 530 540 VSGLMSTLDG KEVAVRYEQL NEEARKLGTS LMSPFMTLSF MSLLVIPELK LGDKGLFDVT 550 KFEFVELFAG E

References

[1]

"The Methanosarcina barkeri genome: comparative analysis with Methanosarcina acetivorans and Methanosarcina mazei reveals extensive rearrangement within methanosarcinal genomes." Maeder D.L., Anderson I., Brettin T.S., Bruce D.C., Gilna P., Han C.S., Lapidus A., Metcalf W.W., Saunders E., Tapia R., Sowers K.R. J. Bacteriol. 188:7922-7931(2006) [PubMed: 16980466] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Fusaro / DSM 804.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000099 Genomic DNA. Translation: AAZ72220.1.
RefSeq	YP_306800.1. NC_007355.1.
3D structure databases
ProteinModelPortal	Q466H2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q466H2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3626200.
GenomeReviews	Gene locus Mbar_A3342 in contig CP000099_GR.
KEGG	mba:Mbar_A3342.
NMPDR	fig|269797.3.peg.1585.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	arNOG05049.
HOGENOM	HBG725357.
OMA	VGLGEMM.
PhylomeDB	Q466H2.
ProtClustDB	CLSK2754571.
Enzyme and pathway databases
BioCyc	MBAR269797:MBAR_A3342-MONOMER.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_METBF

Accession

Primary (citable) accession number: Q466H2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
Last sequence update:	September 13, 2005
Last modified:	November 16, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program