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Protein

Cytolethal distending toxin subunit C

Gene

cdtC

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the tripartite complex that is required for the CDT activity. CdtC, along with CdtA, probably forms a heterodimeric subunit required for the delivery of CdtB.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Ligandi

Lectin

Protein family/group databases

TCDBi1.C.98.1.1. the cytolethal distending toxin (cdt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolethal distending toxin subunit C
Short name:
CDT C
Gene namesi
Name:cdtC
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515PROSITE-ProRule annotationAdd
BLAST
Chaini16 – 181166Cytolethal distending toxin subunit CPRO_0000013375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi16 – 161N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi16 – 161S-diacylglycerol cysteinePROSITE-ProRule annotation

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Heterotrimer of 3 subunits, CdtA, CdtB and CdtC.

Structurei

3D structure databases

ProteinModelPortaliQ46670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 181103Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR003558. CDtoxinA/C.
IPR003559. CDtoxinC.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PRINTSiPR01389. CDTOXINC.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLAIVFTM LLIAGCSSSQ DSANNQIDEL GKENNSLFTF RNIQSGLMIH
60 70 80 90 100
NGLHQHGRET IGWEIVPVKT PEEALVTDQS GWIMIRTPNT DQCLGTPDGR
110 120 130 140 150
NLLKMTCNST AKKTLFSLIP STTGAVQIKS VLSGLCFLDS KNSGLSFETG
160 170 180
KCIADFKKPF EVVPQSHLWM LNPLNTESPI I
Length:181
Mass (Da):19,881
Last modified:November 1, 1996 - v1
Checksum:iD89EB3E4A2744AC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04208 Unassigned DNA. Translation: AAA18787.1.
PIRiI69096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04208 Unassigned DNA. Translation: AAA18787.1.
PIRiI69096.

3D structure databases

ProteinModelPortaliQ46670.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.98.1.1. the cytolethal distending toxin (cdt) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR003558. CDtoxinA/C.
IPR003559. CDtoxinC.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PRINTSiPR01389. CDTOXINC.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes."
    Pickett C.L., Cottle D.L., Pesci E.C., Bikah G.
    Infect. Immun. 62:1046-1051(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: O128:H- / 9142-88 / EPEC.

Entry informationi

Entry nameiCDTC_ECOLX
AccessioniPrimary (citable) accession number: Q46670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon of the strain O128:H- / 9142-88 / EPEC is referred to as cdt type II (CDT-II).

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.