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Protein

Cytolethal distending toxin subunit A

Gene

cdtA

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Toxin

Keywords - Ligandi

Lectin

Protein family/group databases

TCDBi1.C.98.1.1. the cytolethal distending toxin (cdt) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytolethal distending toxin subunit A
Short name:
CDT A
Gene namesi
Name:cdtA
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 258237Cytolethal distending toxin subunit APRO_0000013370Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi22 – 221N-palmitoyl cysteineSequence analysis
Lipidationi22 – 221S-diacylglycerol cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Subunit structurei

Heterotrimer of 3 subunits, CdtA, CdtB and CdtC.

Structurei

3D structure databases

ProteinModelPortaliQ46668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 22399Ricin B-type lectinPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 10412Mediates binding to target cellsBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 ricin B-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR015957. CDtoxinA.
IPR003558. CDtoxinA/C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PIRSFiPIRSF036516. CDT_A. 1 hit.
PRINTSiPR01387. CDTOXINA.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKRTPIFI AGILIPILLN GCSSGKNKAY LDPKVFPPQV EGGPTVPSPD
60 70 80 90 100
EPGLPLPGPG PALPTNGAIP IPEPGTAPAV SLMNMDGSVL TMWSRGAGSS
110 120 130 140 150
LWAYYIGDSN SFGELRNWQI MPGTRPNTIQ FRNVDVGTCM TSFPGFKGGV
160 170 180 190 200
QLSTAPCKFG PERFDFQPMA TRNGNYQLKS LSTGLCIRAN FLGRTPSSPY
210 220 230 240 250
ATTLTMERCP SSGEKNFEFM WSISEPLRPA LATIAKPEIR PFPPQPIEPD

EHSTGGEQ
Length:258
Mass (Da):27,712
Last modified:November 1, 1996 - v1
Checksum:i23A31F3AFD4D2F35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04208 Unassigned DNA. Translation: AAA18785.1.
PIRiI54627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04208 Unassigned DNA. Translation: AAA18785.1.
PIRiI54627.

3D structure databases

ProteinModelPortaliQ46668.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi1.C.98.1.1. the cytolethal distending toxin (cdt) family.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR015957. CDtoxinA.
IPR003558. CDtoxinA/C.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF03498. CDtoxinA. 1 hit.
[Graphical view]
PIRSFiPIRSF036516. CDT_A. 1 hit.
PRINTSiPR01387. CDTOXINA.
SUPFAMiSSF50370. SSF50370. 1 hit.
PROSITEiPS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDTA_ECOLX
AccessioniPrimary (citable) accession number: Q46668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: December 9, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The operon of the strain O128:H- / 9142-88 / EPEC is referred to as cdt type II (CDT-II).

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.