ID   Q46649_ERWAM            Unreviewed;       360 AA.
AC   Q46649;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 77.
DE   SubName: Full=HrcU {ECO:0000313|EMBL:AAB06008.1};
GN   Name=hrcU {ECO:0000313|EMBL:AAB06008.1};
OS   Erwinia amylovora (Fire blight bacteria).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=552 {ECO:0000313|EMBL:AAB06008.1};
RN   [1] {ECO:0000313|EMBL:AAB06008.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=321 {ECO:0000313|EMBL:AAB06008.1};
RX   PubMed=8626302;
RA   Bogdanove A.J., Wei Z.M., Zhao L., Beer S.V.;
RT   "Erwinia amylovora secretes harpin via a type III pathway and contains a
RT   homolog of yopN of Yersinia spp.";
RL   J. Bacteriol. 178:1720-1730(1996).
RN   [2] {ECO:0000313|EMBL:AAB06008.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=321 {ECO:0000313|EMBL:AAB06008.1};
RX   PubMed=20565644; DOI=10.1111/j.1364-3703.2005.00269.x;
RA   Oh C.-S., Kim J.F., Beer S.V.;
RT   "The Hrp pathogenicity island of Erwinia amylovora and identification of
RT   three novel genes required for systemic infectiondouble dagger.";
RL   Mol. Plant Pathol. 6:125-138(2005).
RN   [3] {ECO:0000313|EMBL:AAB06008.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=321 {ECO:0000313|EMBL:AAB06008.1};
RA   Beer S.V.;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the type III secretion exporter family.
CC       {ECO:0000256|ARBA:ARBA00010690}.
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DR   EMBL; L25828; AAB06008.1; -; Genomic_DNA.
DR   RefSeq; WP_004155339.1; NZ_RQKG01000002.1.
DR   AlphaFoldDB; Q46649; -.
DR   GeneID; 8911294; -.
DR   OMA; QQRMSHE; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   Gene3D; 3.40.1690.10; secretion proteins EscU; 1.
DR   InterPro; IPR006307; BsaZ-like.
DR   InterPro; IPR006135; T3SS_substrate_exporter.
DR   InterPro; IPR029025; T3SS_substrate_exporter_C.
DR   NCBIfam; TIGR01404; FlhB_rel_III; 1.
DR   PANTHER; PTHR30531; FLAGELLAR BIOSYNTHETIC PROTEIN FLHB; 1.
DR   PANTHER; PTHR30531:SF14; SURFACE PRESENTATION OF ANTIGENS PROTEIN SPAS; 1.
DR   Pfam; PF01312; Bac_export_2; 1.
DR   PRINTS; PR00950; TYPE3IMSPROT.
DR   SUPFAM; SSF160544; EscU C-terminal domain-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   TRANSMEM        74..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        139..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..18
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  40581 MW;  F5B7769EEB865477 CRC64;
     MAEKTEKPTA KKLQDARRKG QVPQSQDVPK LLICAGVVET VLALDDVGMQ KLQALMMLPL
     ARIGQPFELA LSEVVSSAII LVATFCGLTV AIAALLRIIG GWIQYGPLFA PEALQPDFNR
     LNPINQFKQM FSVKKLSEML NSIVKAVAIC TIFYLVLTPD LESLSRLAYG DLDSFWPAVE
     TLLIHVSRQT LLTLLVLTLL DFGLQKYFFI KQQRMSHQDI RDEHKQSEGD PHMKGHRHAL
     AHELLNQPAT AVKSKPVEEA DLLLVNPTHY AVALYYRPEL TPLPRIICKG EDQQAKELIA
     RAQQANIPVI RFIWLARTLY RSQEGQLIPR HTLQAVAQVY RVLRQLEDQI TDEVIELEAE
//