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Protein
Submitted name:

Serine protease

Gene

bprB

Organism
Dichelobacter nodosus (Bacteroides nodosus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi137Calcium 1Combined sources1
Metal bindingi181Calcium 1Combined sources1
Metal bindingi191Calcium 2Combined sources1
Metal bindingi201Calcium 2Combined sources1
Metal bindingi201Calcium 3Combined sources1
Metal bindingi203Calcium 3Combined sources1
Metal bindingi204Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi206Calcium 2Combined sources1
Metal bindingi206Calcium 3Combined sources1
Metal bindingi208Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi248Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi251Calcium 1Combined sources1
Metal bindingi253Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi255Calcium 1; via carbonyl oxygenCombined sources1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotation

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BRENDAi3.4.21.62. 11943.

Names & Taxonomyi

Protein namesi
Submitted name:
Serine proteaseImported
Gene namesi
Name:bprBImported
OrganismiDichelobacter nodosus (Bacteroides nodosus)Imported
Taxonomic identifieri870 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaCardiobacterialesCardiobacteriaceaeDichelobacter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500423235527 – 603Sequence analysisAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi221 ↔ 273Combined sources
Disulfide bondi315 ↔ 352Combined sources

Interactioni

Protein-protein interaction databases

STRINGi246195.DNO_0605.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TI9X-ray1.80A133-476[»]
ProteinModelPortaliQ46547.
SMRiQ46547.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ46547.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini164 – 460Peptidase S8InterPro annotationAdd BLAST297
Domaini525 – 603P_proproteinInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4105RX7. Bacteria.
COG1404. LUCA.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 2 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q46547-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLSNISAVK VLTLVVSAAI AGQACAAESI VNYESANAIS KQPEGSVRFI
60 70 80 90 100
VKYKDGTPSS QGLKTRSTTK VMASGMQVAG FEAQFVRTTG LGAGIFAVPE
110 120 130 140 150
LKTTKEAHLV MDTIASNPDV EFVEVDRLAY PKAAPNDPSY QQQWHYFGNY
160 170 180 190 200
GVKADKVWDR GFTGQGVVVS VVDTGILDHV DLNGNMLPGY DFISSAPKAR
210 220 230 240 250
DGDQRDNNPA DEGDWFDNWG CGGYPDPRRE KRFSTWHGSH VAGTIAAVTN
260 270 280 290 300
NGVGVAGVAY GAKVIPVRVL GKCGGYDSDI TDGMYWSAGG HIDGVPDNQN
310 320 330 340 350
PAQVINMSLG GDGDCSQSSQ RIIDKTTNLG ALIVIAAGNE NQDASRTWPS
360 370 380 390 400
SCNNVLSVGA TTPKGKRAPF SNYGARVHLA APGTNILSTI DVGQAGPVRS
410 420 430 440 450
SYGMKAGTSM AAPHVSGVAA LVISAANSIG KTLTPSELSD ILVRTTSRFN
460 470 480 490 500
GRLDRGLGSG IVDANAAVNA VLGDQNRAQP RPPVNQPINS GNKVYKSNGK
510 520 530 540 550
VAIRDLRSVT SGIRVNDQAR VGSANITLTL DIRHGDRSLL AVELIAPSGR
560 570 580 590 600
IYPINHDGKR QPNIVGSVTF GVKNERLQGT WTLKVTDKAR GVTGSIDSWG

LTF
Length:603
Mass (Da):63,608
Last modified:November 1, 1996 - v1
Checksum:i94F92BE7BA4260F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37754 Genomic DNA. Translation: AAA80562.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37754 Genomic DNA. Translation: AAA80562.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TI9X-ray1.80A133-476[»]
ProteinModelPortaliQ46547.
SMRiQ46547.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi246195.DNO_0605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105RX7. Bacteria.
COG1404. LUCA.

Enzyme and pathway databases

BRENDAi3.4.21.62. 11943.

Miscellaneous databases

EvolutionaryTraceiQ46547.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 3 hits.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 2 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ46547_DICNO
AccessioniPrimary (citable) accession number: Q46547
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.