Reviewed, UniProtKB/Swiss-Prot Q46526 (COAE_DICNO)

Names and origin

Protein names

Recommended name:
    Dephospho-CoA kinase
    EC=2.7.1.24
Alternative name(s):
    Dephosphocoenzyme A kinase

Gene names

Name:

coaE

Organism

Dichelobacter nodosus (Bacteroides nodosus)

Taxonomic identifier

870 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Cardiobacteriales › Cardiobacteriaceae › Dichelobacter

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A By similarity.
Catalytic activity	ATP + 3'-dephospho-CoA = ADP + CoA. HAMAP MF_00376
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 5/5. HAMAP MF_00376
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the coaE family. Contains 1 DPCK (dephospho-CoA kinase) domain.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP dephospho-CoA kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 197	197	Dephospho-CoA kinase HAMAP MF_00376		PRO_0000172905
Regions
	Domain	2 – 197	196	DPCK
	Nucleotide binding	7 – 14	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q46526-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 24FB4AC7A933BEE0	FASTA	197	22,161
	10 20 30 40 50 60 MIVGLTGGIA SGKTLCCNWF AAQGCYIIDA DLIAKELVTV GGVVWLQLRA HFGETIFYAD 70 80 90 100 110 120 GNLNRALLRE KMFHNQEIKE KVNQIFHPAV RAEIEKRIHL YPHAFTLLDV PLLFETQLHK 130 140 150 160 170 180 ICHMVIVVDI PVSLQIARGV CRDGVNSAQM QRIIASQISR EKRLSLANFI IDNSNSIAQT 190 YQQCQQIYQQ ILSLNAA

References

[1]	"Identification of fimbrial assembly genes from Dichelobacter nodosus: evidence that fimP encodes the type-IV prepilin peptidase." Johnston J.L., Billington S.J., Haring V., Rood J.I. Gene 161:21-26(1995) [PubMed: 7642131] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A198.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U17138 Genomic DNA. Translation: AAB65808.1.
3D structure databases
HSSP	HSSP built from PDB template 1N3B based on UniProtKB P36679.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.1.24. 289778.
Family and domain databases
HAMAP	MF_00376. [Tree]
InterPro	IPR001977. Depp_CoAkinase. [Graphical view]
PANTHER	PTHR10695. Depp_CoAkinase. 1 hit.
Pfam	PF01121. CoaE. 1 hit. [Graphical view]
ProDom	PD003329. Depp_CoAkinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00152. Depp_CoAkinase. 1 hit.
PROSITE	PS51219. DPCK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COAE_DICNO

Accession

Primary (citable) accession number: Q46526

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)