Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q46482

- PUR2_ALLVD

UniProt

Q46482 - PUR2_ALLVD

Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (15 Jun 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi286 – 2861Magnesium or manganeseBy similarity
    Metal bindingi288 – 2881Magnesium or manganeseBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi135 – 19662ATPBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. manganese ion binding Source: UniProtKB-HAMAP
    4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
    2. purine nucleobase biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Purine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAVIN572477:GCJK-831-MONOMER.
    UniPathwayiUPA00074; UER00125.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
    Alternative name(s):
    GARS
    Glycinamide ribonucleotide synthetase
    Phosphoribosylglycinamide synthetase
    Gene namesi
    Name:purD
    Ordered Locus Names:Alvin_0820
    OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
    Taxonomic identifieri572477 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
    ProteomesiUP000001441: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 428428Phosphoribosylamine--glycine ligasePRO_0000151443Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ46482.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 316208ATP-graspAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GARS family.Curated
    Contains 1 ATP-grasp domain.Curated

    Phylogenomic databases

    HOGENOMiHOG000033463.
    KOiK01945.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPiMF_00138. GARS.
    InterProiIPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view]
    PfamiPF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsiTIGR00877. purD. 1 hit.
    PROSITEiPS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q46482-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILIVGSGG REHALAWKAA QSPQVEQVFV APGNGGTASE PGVENVAIAA    50
    DDIAGLVEFA RRESIGLTIV GPEAPLVLGL VDAFAEAGLP CFGPRQASAQ 100
    LEGSKAFAKD FLHRHGIPTA AYGVFTELEP ALAYLRQVGA PVVVKADGLA 150
    AGKGVILADD LATAEAAVHD MLGGGRFGRA GARVVIEEFL TGEEASFIAM 200
    VDGRHILPLA SSQDHKARDD GDRGPNTGGM GAYSPAPIVT PEIHDRIMRE 250
    VMEPTVAGLA AEGLPYLGFL YAGLMIGADG TPKVLEFNCR LGDPETQPLL 300
    MRLQSDLVEL CLAALDGRLD QVTADWDARP ALGVVMAAGG YPDDYETGHV 350
    ISGLDAVPSS EAKVFQAGTR CEGDAILTNG GRVLCVTALG ANVAEAQHLA 400
    YQAVDRIQWT DAFCRRDIGH RAIARERS 428
    Length:428
    Mass (Da):44,805
    Last modified:June 15, 2010 - v2
    Checksum:i3CBFD73C9F913D37
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti95 – 973RQA → ASG in AAB02980. 1 PublicationCurated
    Sequence conflicti159 – 1602DD → MI in AAB02980. 1 PublicationCurated
    Sequence conflicti165 – 1673EAA → GGG in AAB02980. 1 PublicationCurated
    Sequence conflicti174 – 18310GGRFGRAGAR → ADAFGPGGGG in AAB02980. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001896 Genomic DNA. Translation: ADC61767.1.
    L76417 Genomic DNA. Translation: AAB02980.1.
    RefSeqiYP_003442799.1. NC_013851.1.

    Genome annotation databases

    EnsemblBacteriaiADC61767; ADC61767; Alvin_0820.
    GeneIDi8786158.
    KEGGialv:Alvin_0820.
    PATRICi31921393. VBIAllVin64954_0819.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001896 Genomic DNA. Translation: ADC61767.1 .
    L76417 Genomic DNA. Translation: AAB02980.1 .
    RefSeqi YP_003442799.1. NC_013851.1.

    3D structure databases

    ProteinModelPortali Q46482.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADC61767 ; ADC61767 ; Alvin_0820 .
    GeneIDi 8786158.
    KEGGi alv:Alvin_0820.
    PATRICi 31921393. VBIAllVin64954_0819.

    Phylogenomic databases

    HOGENOMi HOG000033463.
    KOi K01945.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00125 .
    BioCyci AVIN572477:GCJK-831-MONOMER.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 1 hit.
    3.40.50.20. 1 hit.
    3.90.600.10. 1 hit.
    HAMAPi MF_00138. GARS.
    InterProi IPR011761. ATP-grasp.
    IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR020561. PRibGlycinamid_synth_ATP-grasp.
    IPR000115. PRibGlycinamide_synth.
    IPR020560. PRibGlycinamide_synth_C-dom.
    IPR020559. PRibGlycinamide_synth_CS.
    IPR020562. PRibGlycinamide_synth_N.
    IPR011054. Rudment_hybrid_motif.
    [Graphical view ]
    Pfami PF01071. GARS_A. 1 hit.
    PF02843. GARS_C. 1 hit.
    PF02844. GARS_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51246. SSF51246. 1 hit.
    SSF52440. SSF52440. 1 hit.
    TIGRFAMsi TIGR00877. purD. 1 hit.
    PROSITEi PS50975. ATP_GRASP. 1 hit.
    PS00184. GARS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
      Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
    2. Chen Y.L., Knaff D.B.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-189.

    Entry informationi

    Entry nameiPUR2_ALLVD
    AccessioniPrimary (citable) accession number: Q46482
    Secondary accession number(s): D3RQG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3