Reviewed, UniProtKB/Swiss-Prot Q46482 (PUR2_CHRVI)

Names and origin

Protein names

Recommended name:
    Phosphoribosylamine--glycine ligase
    EC=6.3.4.13
Alternative name(s):
    GARS
    Glycinamide ribonucleotide synthetase
    Phosphoribosylglycinamide synthetase

Gene names

Name:

purD

Organism

Chromatium vinosum (Allochromatium vinosum)

Taxonomic identifier

1049 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Allochromatium

Protein attributes

Sequence length	189 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP MF_00138
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP MF_00138
Sequence similarities	Belongs to the GARS family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	purine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylamine-glycine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›189	›189	Phosphoribosylamine--glycine ligase HAMAP MF_00138		PRO_0000151443
Regions
	Domain	109 – ›189	›81	ATP-grasp
	Nucleotide binding	135 – 159	25	ATP By similarity
Experimental info
	Non-terminal residue	189	1

Sequences

	Sequence		Length	Mass (Da)
	Q46482-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C9F39F5EEE4A6BEC	FASTA	189	18,912
	10 20 30 40 50 60 MKILIVGSGG REHALAWKAA QSPQVEQVFV APGNGGTASE PGVENVAIAA DDIAGLVEFA 70 80 90 100 110 120 RRESIGLTIV GPEAPLVLGL VDAFAEAGLP CFGPASGSAQ LEGSKAFAKD FLHRHGIPTA 130 140 150 160 170 180 AYGVFTELEP ALAYLRQVGA PVVVKADGLA AGKGVILAMI LATAGGGVHD MLGADAFGPG GGGVVIEEF

References

[1]	Chen Y.L., Knaff D.B. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 17899 / DSM 180 / D.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L76417 Genomic DNA. Translation: AAB02980.1.
3D structure databases
HSSP	HSSP built from PDB template 1GSO based on UniProtKB P15640.
ModBase	Search...
Enzyme and pathway databases
BRENDA	6.3.4.13. 2799.
Family and domain databases
HAMAP	MF_00138. [Tree]
InterPro	IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR000115. Gars. IPR013817. Pre-ATP_grasp. [Graphical view]
Gene3D	G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
Pfam	PF01071. GARS_A. 1 hit. PF02844. GARS_N. 1 hit. [Graphical view]
PROSITE	PS50975. ATP_GRASP. 1 hit. PS00184. GARS. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR2_CHRVI

Accession

Primary (citable) accession number: Q46482

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)