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Q46482

- PUR2_ALLVD

UniProt

Q46482 - PUR2_ALLVD

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Protein

Phosphoribosylamine--glycine ligase

Gene

purD

Organism
Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi286 – 2861Magnesium or manganeseBy similarity
Metal bindingi288 – 2881Magnesium or manganeseBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi135 – 19662ATPBy similarityAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. manganese ion binding Source: UniProtKB-HAMAP
  4. phosphoribosylamine-glycine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
  2. purine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAVIN572477:GCJK-831-MONOMER.
UniPathwayiUPA00074; UER00125.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylamine--glycine ligase (EC:6.3.4.13)
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene namesi
Name:purD
Ordered Locus Names:Alvin_0820
OrganismiAllochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum)
Taxonomic identifieri572477 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaChromatialesChromatiaceaeAllochromatium
ProteomesiUP000001441: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Phosphoribosylamine--glycine ligasePRO_0000151443Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ46482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 316208ATP-graspAdd
BLAST

Sequence similaritiesi

Belongs to the GARS family.Curated
Contains 1 ATP-grasp domain.Curated

Phylogenomic databases

HOGENOMiHOG000033463.
KOiK01945.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPiMF_00138. GARS.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamiPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMiSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR00877. purD. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q46482-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKILIVGSGG REHALAWKAA QSPQVEQVFV APGNGGTASE PGVENVAIAA
60 70 80 90 100
DDIAGLVEFA RRESIGLTIV GPEAPLVLGL VDAFAEAGLP CFGPRQASAQ
110 120 130 140 150
LEGSKAFAKD FLHRHGIPTA AYGVFTELEP ALAYLRQVGA PVVVKADGLA
160 170 180 190 200
AGKGVILADD LATAEAAVHD MLGGGRFGRA GARVVIEEFL TGEEASFIAM
210 220 230 240 250
VDGRHILPLA SSQDHKARDD GDRGPNTGGM GAYSPAPIVT PEIHDRIMRE
260 270 280 290 300
VMEPTVAGLA AEGLPYLGFL YAGLMIGADG TPKVLEFNCR LGDPETQPLL
310 320 330 340 350
MRLQSDLVEL CLAALDGRLD QVTADWDARP ALGVVMAAGG YPDDYETGHV
360 370 380 390 400
ISGLDAVPSS EAKVFQAGTR CEGDAILTNG GRVLCVTALG ANVAEAQHLA
410 420
YQAVDRIQWT DAFCRRDIGH RAIARERS
Length:428
Mass (Da):44,805
Last modified:June 15, 2010 - v2
Checksum:i3CBFD73C9F913D37
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 973RQA → ASG in AAB02980. 1 PublicationCurated
Sequence conflicti159 – 1602DD → MI in AAB02980. 1 PublicationCurated
Sequence conflicti165 – 1673EAA → GGG in AAB02980. 1 PublicationCurated
Sequence conflicti174 – 18310GGRFGRAGAR → ADAFGPGGGG in AAB02980. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001896 Genomic DNA. Translation: ADC61767.1.
L76417 Genomic DNA. Translation: AAB02980.1.
RefSeqiWP_012970043.1. NC_013851.1.
YP_003442799.1. NC_013851.1.

Genome annotation databases

EnsemblBacteriaiADC61767; ADC61767; Alvin_0820.
GeneIDi8786158.
KEGGialv:Alvin_0820.
PATRICi31921393. VBIAllVin64954_0819.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001896 Genomic DNA. Translation: ADC61767.1 .
L76417 Genomic DNA. Translation: AAB02980.1 .
RefSeqi WP_012970043.1. NC_013851.1.
YP_003442799.1. NC_013851.1.

3D structure databases

ProteinModelPortali Q46482.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADC61767 ; ADC61767 ; Alvin_0820 .
GeneIDi 8786158.
KEGGi alv:Alvin_0820.
PATRICi 31921393. VBIAllVin64954_0819.

Phylogenomic databases

HOGENOMi HOG000033463.
KOi K01945.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00125 .
BioCyci AVIN572477:GCJK-831-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPi MF_00138. GARS.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view ]
Pfami PF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR00877. purD. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Allochromatium vinosum DSM 180."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.
  2. Chen Y.L., Knaff D.B.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-189.

Entry informationi

Entry nameiPUR2_ALLVD
AccessioniPrimary (citable) accession number: Q46482
Secondary accession number(s): D3RQG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: June 15, 2010
Last modified: November 26, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3