Q46481 (LPXA_ALLVD) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Short name=UDP-N-acetylglucosamine acyltransferase
EC=2.3.1.129

Gene names

Name:	lpxA
Ordered Locus Names:	Alvin_0821

Organism

Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / D) (Chromatium vinosum) [Complete proteome] [HAMAP]

Taxonomic identifier

572477 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Chromatiales › Chromatiaceae › Allochromatium › Chromatium vinosum

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00387
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetyl-alpha-D-glucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine. HAMAP-Rule MF_00387
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. HAMAP-Rule MF_00387
Subunit structure	Homotrimer By similarity. HAMAP-Rule MF_00387
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00387.
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxA subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase HAMAP-Rule MF_00387		PRO_0000188045
Experimental info
	Sequence conflict	209	1	R → A in AAB02979. Ref.1
	Sequence conflict	230	1	R → RI in AAB02979. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q46481 [UniParc]. Last modified June 15, 2010. Version 2. Checksum: 3C6A569AABFED137	FASTA	258	28,144
	10 20 30 40 50 60 MRIHPTAIVE DGAQLHDSVT VGPYSIIESG AVIGEGCRIE SNVRIFGVTR MGAHNRVCHG 70 80 90 100 110 120 ATLGSEPQDL SFTPEKARPL IIGDHNHFKE CVNISGGIKS EGGTRIGSHN YWMAFSHAGH 130 140 150 160 170 180 DCVVGDHNVF ANTATLAGHV EIDDHCFLSG QVAVHQFCRI GSYVMIAGVT GVPQDVPPYM 190 200 210 220 230 240 LADGHRARLI GLNVVGLRRN GFGQEQRTRI KQVYRLILRS GLRLDDALQR AEDEYPGPET 250 KRIVAFIRAS RRGIVSFG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Chen Y.L., Knaff D.B. Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome of Allochromatium vinosum DSM 180." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N., Zigann R., Dahl C., Woyke T. Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 17899 / DSM 180 / NBRC 103801 / D.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L76417 Genomic DNA. Translation: AAB02979.1. CP001896 Genomic DNA. Translation: ADC61768.1.
RefSeq	YP_003442800.1. NC_013851.1.
3D structure databases
ProteinModelPortal	Q46481.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADC61768; ADC61768; Alvin_0821.
GeneID	8786159.
KEGG	alv:Alvin_0821.
PATRIC	31921395. VBIAllVin64954_0820.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000294326.
KO	K00677.
Enzyme and pathway databases
BioCyc	AVIN572477:GCJK-832-MONOMER.
UniPathway	UPA00359; UER00477.
Family and domain databases
HAMAP	MF_00387. LpxA.
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_LpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. lipid_A_lpxA. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXA_ALLVD

Accession

Primary (citable) accession number: Q46481
Secondary accession number(s): D3RQG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	June 15, 2010
Last modified:	May 29, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program